Results 81 to 90 of about 736,445 (300)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
On-Chip time measurement architectures and implementation
, 2009 In recent years, system on chip (SoC) devices have become increasingly popular in many applications, such as automotive, signal processing, portable electronic devices and communication products. This has led to more functionality being integrated onto a
Collins, Matthew
core +1 more source
An investigation of the effects of cryogen application direction on Ti6Al4V alloy milling
Journal of Advances in Manufacturing Engineering, 2021 Titanium and its alloys are materials with high hardness and strength. Because of these properties, titanium and its alloys are usually machined with carbide or diamond tools.
Erkan Bahçe, Eray Sarıgül
doaj
A high speed truly random number generator based on thermal noise oscilltor
Dianzi Jishu Yingyong, 2018 A truly random number generator based on thermal noise was proposed, and the resistance thermal noise was used as the noise source of the low frequency clock. It uses two independent working relative relationship between high and low frequency oscillator
Wei Zikui +9 more
doaj +1 more source
, 2015 Uji IPhone 4s Perbedaan features dan kemampuan iPhone 4s dan iPhone 4 Smartphone Hacking Tips mengoptimalkan ...
Majalah Chip
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Comparison and Realization of Fast Acquisition Method for GPS Signal under High Dynamic
MATEC Web of Conferences, 2017 In order to solve the problem of fast acquisition for GPS signal under high dynamic, the paper add window in traditional Partial Matched Filter (PMF) plus Fast Fourier Transform (FFT) for fast acquisition with the purpose of reducing the scalloping loss ...
Zeng Chan +3 more
doaj +1 more source
Hardware sollution about power fail protective mechanism of non volatile memory
Dianzi Jishu Yingyong, 2019 The principle of data power failure protection for non-volatile memory(NVM) of security chip is analyzed. Considering that the processing speed of software can not meet the performance requirements of security chip for data storage, this paper proposes a
Su Wei +4 more
doaj +1 more source