Results 81 to 90 of about 1,103,019 (210)

Considering the Risks and Costs of Solid Organ Xenotransplantation

open access: yesAdvanced Biology, EarlyView.
This perspective discusses the rationale, risks, and costs of whole‐organ xenotransplantation. It considers alternative strategies to obviate the demand for transplants and optimize allotransplantation systems and practices that do not impose xenotransplantation's harms and risks, and whether they are the most ethical and effective means to increase ...
Catharine E. Krebs   +5 more
wiley   +1 more source

Surface-acoustic-wave driven silicon microfluidic chips for acoustic tweezing of motile cells and viscoelastic microbeads [PDF]

open access: yesarXiv
Acoustic tweezers comprising a surface acoustic wave chip and a disposable silicon microfluidic chip are potentially advantageous to stable and cost-ffective acoustofluidic experiments while avoiding the cross-contamination by reusing the surface acoustic wave chip and disposing of the microfluidic chip.
arxiv  

Preventive Effect of Metformin in Radiation‐Induced Xerostomia

open access: yesAdvanced Biology, EarlyView.
Head and neck cancer patients who received radiotherapy complain of severe dry mouth due to damage to the salivary glands. Metformin is an antidiabetic drug, but its radio‐protective effect has been reported. It is confirmed that metformin protects the salivary glands from radiation and provides evidence for the use of metformin in cancer treatment in ...
Sungryeal Kim   +5 more
wiley   +1 more source

ChipAlign: Instruction Alignment in Large Language Models for Chip Design via Geodesic Interpolation [PDF]

open access: yesarXiv
Recent advancements in large language models (LLMs) have expanded their application across various domains, including chip design, where domain-adapted chip models like ChipNeMo have emerged. However, these models often struggle with instruction alignment, a crucial capability for LLMs that involves following explicit human directives.
arxiv  

Current and Future Cornea Chip Models for Advancing Ophthalmic Research and Therapeutics

open access: yesAdvanced Biology, EarlyView.
This review analyzes cornea chip technology as an innovative solution to corneal blindness and tissue scarcity. The examination encompasses recent developments in biomaterial design and fabrication methods replicating corneal architecture, highlighting applications in drug screening and disease modeling while addressing key challenges in mimicking ...
Minju Kim   +3 more
wiley   +1 more source

Mechanical Loading of Osteocytes via Oscillatory Fluid Flow Regulates Early‐Stage PC‐3 Prostate Cancer Metastasis to Bone

open access: yesAdvanced Biology, EarlyView.
In this study, the authors show that osteocytes, mechanosensing cells embedded within bone, can indeed regulate prostate cancer cell extravasation through a blood vessel using a physiologically relevant tissue model. Specifically, it is shown that osteocytes modulate the expression of blood vessel cell adhesion molecules, affecting the frequency at ...
Kimberly Seaman   +7 more
wiley   +1 more source

Numerical Studies of Influencing Factors on the Homogeneity of the Powder Mixture during the Powder Spreading Process of Powder Bed Fusion–Laser Beam/Metal

open access: yesAdvanced Engineering Materials, EarlyView.
AISI 304L stainless steel powder is mixed with silicon nitride (Si3N4) powder and processed by PBF‐LB/M, allowing partial retention of Si3N4. The numerical approach effectively predicts the Si3N4 powder homogeneity and N content distribution on the powder bed. Recent studies have focused on the alloying of nitrogen (N) in high‐alloy stainless steels by
Yuanbin Deng   +7 more
wiley   +1 more source

Modeling and Accessing Smart Materials with Integrity Constraints in the Shapes Constraint Language and Ontologies—The SmaDi Way

open access: yesAdvanced Engineering Materials, EarlyView.
Integrity constraints enforce consistency and completeness on data. The article discusses a newly developed validator for checking integrity constraints in Shapes Constraint Language (SHACL) through reduction to SPARQL Protocol and RDF Query Language (SPARQL) queries. It can be used with systems for ontology‐based database access.
Özgür L. Özçep   +5 more
wiley   +1 more source

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