Results 81 to 90 of about 1,488,806 (302)

Development of HTU-model variable chipping clearance cassava chipper [PDF]

open access: diamond, 2021
Samuel Kojo Ahorsu   +5 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

A high speed truly random number generator based on thermal noise oscilltor

open access: yesDianzi Jishu Yingyong, 2018
A truly random number generator based on thermal noise was proposed, and the resistance thermal noise was used as the noise source of the low frequency clock. It uses two independent working relative relationship between high and low frequency oscillator
Wei Zikui   +9 more
doaj   +1 more source

Robotics in space-age manufacturing [PDF]

open access: yes
Robotics technologies are developed to improve manufacturing of space hardware. The following applications of robotics are covered: (1) welding for the space shuttle and space station Freedom programs; (2) manipulation of high-pressure water for shuttle ...
Jones, Chip
core   +1 more source

Optimal microscale water cooled heat sinks for targeted alleviation of hotspot in microprocessors [PDF]

open access: yes, 2014
This paper was presented at the 4th Micro and Nano Flows Conference (MNF2014), which was held at University College, London, UK. The conference was organised by Brunel University and supported by the Italian Union of Thermofluiddynamics, IPEM, the ...
4th Micro and Nano Flows Conference (MNF2014)   +3 more
core  

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

open access: yesMolecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad   +12 more
wiley   +1 more source

Hardware sollution about power fail protective mechanism of non volatile memory

open access: yesDianzi Jishu Yingyong, 2019
The principle of data power failure protection for non-volatile memory(NVM) of security chip is analyzed. Considering that the processing speed of software can not meet the performance requirements of security chip for data storage, this paper proposes a
Su Wei   +4 more
doaj   +1 more source

On-chip mode division (de)multiplexer for multi-band operation

open access: gold, 2022
Qianshi Wang   +6 more
openalex   +1 more source

Towards on-chip generation, routing and detection of non-classical light

open access: yes, 2015
We fabricate an integrated photonic circuit with emitter, waveguide and detector on one chip, based on a hybrid superconductor-semiconductor system. We detect photoluminescence from self-assembled InGaAs quantum dots on-chip using NbN superconducting ...
Andrejew, Alexander   +7 more
core   +1 more source

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