Results 81 to 90 of about 1,997,289 (379)

Integrated microfluidic tmRNA purification and real-time NASBA device for molecular diagnostics. [PDF]

open access: yes, 2008
We demonstrate the first integrated microfluidic tmRNA purification and nucleic acid sequence-based amplification (NASBA) device incorporating real-time detection.
Antonio J. Ricco   +48 more
core   +1 more source

ChIPpeakAnno: a Bioconductor package to annotate ChIP-seq and ChIP-chip data [PDF]

open access: yesBMC Bioinformatics, 2010
Chromatin immunoprecipitation (ChIP) followed by high-throughput sequencing (ChIP-seq) or ChIP followed by genome tiling array analysis (ChIP-chip) have become standard technologies for genome-wide identification of DNA-binding protein target sites. A number of algorithms have been developed in parallel that allow identification of binding sites from ...
Zhu, Lihua Julie   +6 more
openaire   +4 more sources

ChIP-seq guidelines and practices of the ENCODE and modENCODE consortia

open access: yesGenome Research, 2012
Chromatin immunoprecipitation (ChIP) followed by high-throughput DNA sequencing (ChIP-seq) has become a valuable and widely used approach for mapping the genomic location of transcription-factor binding and histone modifications in living cells.
S. Landt   +47 more
semanticscholar   +1 more source

Is it Time for Reviewer 3 to Request Human Organ Chip Experiments Instead of Animal Validation Studies?

open access: yesAdvancement of science, 2020
For the past century, experimental data obtained from animal studies have been required by reviewers of scientific articles and grant applications to validate the physiological relevance of in vitro results.
D. Ingber
semanticscholar   +1 more source

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

open access: yesMolecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen   +12 more
wiley   +1 more source

Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren   +16 more
wiley   +1 more source

Examining performance calibration in smart power system electricity metering based on environmental perception attention LSTM-network

open access: yesFrontiers in Energy Research
The operating environment greatly influences the accuracy of power metering devices, resulting in variations and inconsistencies in measurement results across different working situations.
Bo Zhang   +9 more
doaj   +1 more source

Structural Strength of Cemented Carbides

open access: yesJournal of Mechanical Engineering, 2021
The concept “structural strength of tool materials” got further development. The refusals of cemented carbide cutting plates, when heavy machining were analyzed.
Olena Soroka   +3 more
doaj   +1 more source

Evolution of Biochip Technology: A Review from Lab-on-a-Chip to Organ-on-a-Chip

open access: yesMicromachines, 2020
Following the advancements in microfluidics and lab-on-a-chip (LOC) technologies, a novel biomedical application for microfluidic based devices has emerged in recent years and microengineered cell culture platforms have been created. These micro-devices,
Neda Azizipour   +4 more
semanticscholar   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

open access: yesMolecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp   +13 more
wiley   +1 more source

Home - About - Disclaimer - Privacy