Results 101 to 110 of about 4,535,109 (297)

Influence of Machining Parameters on Cutting and Chip-Formation Process during Cortical Bone Orthogonal Machining. [PDF]

Materials (Basel), 2022
Zawadzki P, Talar R, Patalas A, Legutko S.   +3 more
europepmc   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Paper-Based Electrodeposition Chip for 3D Alginate Hydrogel Formation

Micromachines, 2015
Hydrogel has been regarded as one significant biomaterial in biomedical and tissue engineering due to its high biocompatibility. This paper proposes a novel method to pattern calcium alginate hydrogel in a 3D way via electrodeposition process based on a ...
Wenfeng Wan, Gaole Dai, Lijun Zhang, Yajing Shen   +3 more
doaj   +1 more source

A Joint Johnson-Cook-TANH Constitutive Law for Modeling Saw-Tooth Chip Formation of Ti-6AL-4V Based on an Improved Smoothed Particle Hydrodynamics Method. [PDF]

Materials (Basel), 2023
Niu W, Wang Y, Li X, Guo R.
europepmc   +1 more source

A review of wood machining literature with a special focus on sawing [PDF]

, 2013
In this review, fundamental wood machining research is evaluated to determine the general cutting mechanics of simple, orthogonal, and oblique cutting tools. Simple tool force trends and chip formation characteristics are indentified here, along with the
Phil Hackney, Naylor, Andrew, Hackney, P, Hackney, Philip, Andrew Naylor, Naylor, A   +5 more
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Simulation of plastic deformation and destruction in the process of chip formation

MATEC Web of Conferences, 2018
Metal cutting is a complex process in which several mechanisms are at work simultaneously. The mathematical modelling allows carrying out research into the optimization of machining conditions.
Tärgla Tanel, Olt Jüri, Liivapuu Olga
doaj   +1 more source

FEM and Analytical Modeling of the Incipient Chip Formation for the Generation of Micro-Features. [PDF]

Materials (Basel), 2021
Lanzetta M, Gharibi A, Picchi Scardaoni M, Vivaldi C.   +3 more
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Analysis of the Material Removal Process in Precision Milling of AZ91D Magnesium Alloy

Micromachines
The study investigated the material removal process during precision milling of AZ91D magnesium alloy. A high-speed camera enabling high-frequency image recording was used to observe the cutting zone.
Jarosław Korpysa
doaj   +1 more source