Results 81 to 90 of about 4,535,109 (297)

Theoretical analysis of serrated chip formation based on ideal models in high speed cutting

, 2010
In this paper, two ideal formation models of serrated chips, the symmetric formation model and the unilateral right-angle formation model, have been established for the first time. Based on the ideal models and related adiabatic shear theory of serrated
Gao, Chongyang, Chong Yang Gao, Bin Fang, Gu, YuanTong, Fang, Bin, Yuan Tong Gu   +5 more
core   +1 more source

Adaptable Switch boxes as on-chip routing nodes for networks-on-chip [PDF]

, 2005
Eickhoff R, Niemann J-C, Porrmann M, Rückert U. Adaptable Switch boxes as on-chip routing nodes for networks-on-chip. In: Rettberg A, Zanella MC, Rammig FJ, eds. From Specification to Embedded Systems Application .
Eickhoff, Ralf, Rettberg, Achim, Porrmann, Mario ; https://orcid.org/, Rückert, Ulrich, Rammig, Franz Josef, Zanella, Mauro C., Niemann, Jörg-Christian   +6 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Evaluation of Laser Structuring in Hard Turning Process of Martensitic Steel

Journal of Manufacturing and Materials Processing
The hard turning process presents significant challenges compared to conventional turning techniques, particularly in terms of controlling machining forces and dimensional accuracy. This study evaluates the effectiveness of laser structuring in enhancing
Esmaeil Ghadiri Zahrani, Amir Alinaghizadeh, Amirmohammad Fakharzadeh Jahromi, Bahman Azarhoushang   +3 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Microstructure and mechanism of adiabatic shear fracture during serrated chip formation of hard machining

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2014
The formation and development of serrated chip morphology and adiabatic shear bands (ASBs) and the microstructure of fracture surfaces in the serrated chips during hard machining of hardened alloy steel are observed, the mechanism of adiabatic shear ...
Chunzheng DUAN, Minjie WANG
doaj   +1 more source

Chip Edisi 01/2012

, 2015
Uji IPhone 4s Perbedaan features dan kemampuan iPhone 4s dan iPhone 4 Smartphone Hacking Tips mengoptimalkan ...
Majalah Chip
core  

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source