Results 61 to 70 of about 4,535,109 (297)

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Establish Using FEM Method of Constitutive Model for Chip Formation in the Cutting Process of Gray Cast Iron

Metals, 2019
The constitutive equation of mechanics, namely the stress−strain model of the material, is used to describe the mathematical expression of the mechanical properties of the material (stress−strain−intensity−time relationship).
Lihui Tu, Weimin Shi
doaj   +1 more source

Scalability of Network-on-Chip communication architecture for 3-D meshes. [PDF]

, 2009
Design constraints imposed by global interconnect delays as well as limitations in integration of disparate technologies make 3D chip stacks an enticing technology solution for massively integrated electronic systems.
Awet Yemane Weldezion, Tenhunen, Hannu, Matt Grange, Roshan Weerasekera, Grange, M, Jantsch, A, Weldezion, Awet Yemane,, Pamunuwa, Dinesh Bandara, Jantsch, A., Zhonghai Lu, Lu, Zhonghai, Pamunuwa, Dinesh, Dinesh Pamunuwa, Pamunuwa, I D B, Axel Jantsch, Weldezion, A., Weldezion, A. Y., Jantsch, Axel,, Tenhunen, Hannu,, Weerasekera, Roshan, Hannu Tenhunen, Tenhunen, H, Grange, M., Lu, Zhonghai,, Weerasekera, R., Grange, Matt   +25 more
core   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

The Simulation Analysis of Cutting Characteristics and Chip Formation Mechanism in Gear Skiving

Applied Sciences
Gear skiving is an efficient and high-precision gear processing method, particularly advantageous for internal gears and coupling gears. However, the main limitation of its application is the rapid wear of skiving tools.
Run Mao, Pei Tang, Yudong Zhang, Le Wang, Zheng Guo, Shimin Mao   +5 more
doaj   +1 more source

Micro Ball End Milling of Titanium Alloy Using a Tool with a Microstructured Rake Face

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2012
Many parts and structures for aerospace engineering, marine engineering, bioengineering, etc. are made of titanium alloy because of its excellent physical, chemical, biological and mechanical properties.
Toshiyuki OBIKAWA, Bunji KANI
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

The microstructure infl uence on the chip formation process of Al-Cu alloy cast conventionally and in semi solid state

Metalurgija, 2012
For many metal alloys, the process of metal cutting is accompanied by extensive plastic deformation and fracture. To study this process, quick stop sectional samples of hypoeutectic Al-Cu alloy chip formation, either as conventionally cast alloy or as ...
P. Kovač, L. Sidjanin, D. Rajnović, B. Savković, J. Wannasin   +4 more
doaj  

Observation of chip-producing behavior in ultraprecision diamond cutting of additively manufactured Alloy 718 utilizing ultrasonic elliptical vibration

Journal of Advanced Mechanical Design, Systems, and Manufacturing
The demand for Ni-based alloys, particularly Alloy 718, is increasing in the gas turbine industry due to their high-temperature resistance and chemical stability.
Shunsaku KAWASAKI, Norio YAMASHITA, Shinya MORITA, Hideo YOKOTA   +3 more
doaj   +1 more source

Cutting Force Prediction in Drilling of Titanium Alloy

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2012
Cutting force in drilling of Ti-6Al-4V is studied with simulation based on a predictive model. In the force model, three-dimensional chip flow is made by piling up the orthogonal cuttings in the planes containing the cutting velocities and the chip flow ...
Shoichi TAMURA, Takashi MATSUMURA, Pedro J. ARRAZOLA   +2 more
doaj   +1 more source