Results 41 to 50 of about 4,535,109 (297)

Mechanism of Chip Formation Process at Grinding [PDF]

MATEC Web of Conferences, 2019
The mechanism of chip formation process at grinding is described, which involves a high-speed interaction of abrasive grain and metal, which leads to a concentration of thermal energy in front of the dispersing element (grain), causing a locally ...
Shumyacher Vyacheslav, Kryukov Sergey, Kulik Olga, Kennedy Xavier   +3 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Ultrasound assisted particle and cell manipulation on-chip [PDF]

, 2013
Ultrasonic fields are able to exert forces on cells and other micron-scale particles, including microbubbles. The technology is compatible with existing lab-on-chip techniques and is complementary to many alternative manipulation approaches due to its ...
Cochran, Sandy, Mulvana, Helen, Hill, Martyn   +2 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Simulation of Drilling Process for Control of Burr Formation

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2010
An analytical force model is presented to simulate the cutting force and the chip flow direction in the drilling process. Three dimensional chip flow is interpreted as a piling up of the orthogonal cuttings in the planes containing the cutting velocities
Takashi MATSUMURA, Jürgen LEOPOLD
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Stochastic mathematical model for rock cutting force generation

Горные науки и технологии
A mathematical model describing the formation of dynamic load components acting on the working units of mining machines during rock cutting is an essential component of the digital twin of a mining shearer and is used for engineering analysis, design ...
V. P. Kondrakhin, V. O. Gutarevich
doaj   +1 more source

Toward a better understanding of tool wear effect through a comparison between experiments and SPH numerical modelling of machining hard materials [PDF]

, 2009
The aim of this study is to improve the general understanding of tungsten carbide (WC–Co) tool wear under dry machining of the hard-to-cut titanium alloy Ti6Al4V. The chosen approach includes experimental and numerical tests.
Salaün, Michel, Chieragatti, Rémy, M. Salaün, GIROT, Franck, Espinosa, Christine, Girot, F., COUPARD, Dominique, Nouari, Mohammed, J. Limido, D. Coupard, R. Chieragatti, Calamaz, Madalina, F. Girot, C. Espinosa, M. Calamaz, M. Nouari, Coupard, D., Limido, Jérôme   +17 more
core   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

A Mathematical Model of the Cutting Force while Turning AISI 5140 Steel with P20 Carbide Inserts

Журнал інженерних наук
This article deals with the prediction of the main component of cutting force during turning operations. Currently, cutting force modeling is predominantly based on experimental data and is therefore largely empirical.
Stanislav Shvets, Vitalii Kolesnyk, Ivan Dehtiarov, Roman Shvets, Vladimír Šimna, Andrii Dovhopolov, Yurii Nekrasov, Bohdan Medvediev   +7 more
doaj   +1 more source