Results 31 to 40 of about 4,535,109 (297)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

On the Physics of Machining Titanium Alloys: Interactions between Cutting Parameters, Microstructure and Tool Wear

Metals, 2014
The current work deals with the analysis of mechanisms involved during the machining process of titanium alloys. Two different materials were chosen for the study: Ti-6Al-4V and Ti-55531.
Mohammed Nouari, Hamid Makich
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

High-resolution and multi-range particle separation by microscopic vibration in an optofluidic chip

, 2017
An optofluidic chip is demonstrated in experiments for high-resolution and multi-range particle separation through the optically-induced microscopic vibration effect, where nanoparticles are trapped in loosely overdamped optical potential wells created ...
Zhang, Jing Bo, Liedberg, B., Liedberg, Bo, P. H. Yap, Y. Zhang, Yap, P. H., Zhang, Yi, Xiong, S., Zhang, Y., Chen, T. N., Y. L. Hao, Chin, Lip Ket, Chin, L. K., S. Xiong, Shi, Yu Zhi, Ser, Wee, Y. Yang, W. Ser, Liu, A. Q., J. B. Zhang, Xiong, Sha, Hao, Yi Long, J. H. Wu, Hao, Y. L., Chen, Tian Ning, A. Q. Liu, Y. Z. Shi, Wu, Jiu Hui, Zhang, J. B., B. Liedberg, Yang, Z. C., Yang, Y., Wu, J. H., Ser, W., Yang, Zhen Chuan, Yap, Peng Huat, Shi, Y. Z., Liu, Ai Qun, T. N. Chen, Z. C. Yang, L. K. Chin, Yang, Yi   +41 more
core   +1 more source

Integrated Parylene LC-ESI on a Chip [PDF]

, 2005
In this thesis, several microfluidic devices will be introduced to demonstrate the integration capability of a multilayer parylene surface micromachining technology.
Xie, Jun
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Influence of Cutting Wedge Geometry Design on Cutting Forces, Chip Formation and Surface Roughness During Free Machining of Aluminum Alloy

Journal of Manufacturing and Materials Processing
This study investigates the effects of the rake angle and clearance angle of custom-manufactured HSS-E Co5 high-speed steel cutting tools on the Fc main cutting force, the Fp passive force component, the Ra and Rz surface roughness parameters, and chip ...
Norbert Szabó, Gábor Kónya
doaj   +1 more source

Analysis of Microstructure and Chip Formation When Machining Ti-6Al-4V

Metals, 2018
Microstructure and chip formation were evaluated during the step shoulder down-milling of Ti-6Al-4V using a water-miscible vegetable oil-based cutting fluid.
Islam Shyha, Salah Gariani, Mahmoud Ahmed El-Sayed, Dehong Huo   +3 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source