Results 31 to 40 of about 730 (259)
Perivascular matrix densification promotes the emergence of aberrant endothelial tip cells (ATECs) that invade and persist within fibrotic microenvironments. Using in vivo lineage tracing and a human microvessel model, this study shows that fibrous matrix cues destabilize VE‐cadherin–mediated junctions to gate TGF‐β signaling, inducing a pro ...
Jingyi Xia +17 more
wiley +1 more source
This doctoral research highlights the complicated trajectories of hunter-gatherers by offering a case study from an understudied but rich hunter-gatherer landscape, the Late Archaic period (c. 5,000-2,000 BP) on Grand Island in Michigan’s Upper Peninsula,
Fernanda Neubauer
doaj +1 more source
CD4+ Tregs Drive Post‐Ischemic Sprouting Angiogenesis via Endothelial YY1/MAML1 Reactivation
ABSTRACT Microvascular complications of diabetes are chronic diseases of small vessels. We previously found that CD4+ regulatory T‐cells (Tregs) are markedly reduced in type 2 diabetes (T2D) after ischemic injury in both mice and humans, and that Treg deficiency in immunodeficient mice impairs vascular regeneration.
Hang Qu +10 more
wiley +1 more source
Approaching household units from chipped stone assemblages at Alsónyék-Bátaszék, south Hungary
This article summarizes the current state of research on the chipped stone assemblages from the settlement of Alsónyék-Bátaszék. This site belongs to the southeast Transdanubian group of the Late Neolithic Lengyel culture.
Kata Szilágyi
doaj
This paper analyses the production processes of chipped stone artefacts from ten Starčevo culture sites in the area between the rivers Sava, Drava and Danube.
Rajna Sošić Klindžić
doaj +1 more source
In renal calcium oxalate stone formation, G6PC downregulation leads to lactate accumulation. This lactate mediates CBP/p300‐dependent lactylation of SNAIL1 at K206, promoting its nuclear translocation. Nuclear SNAIL1 activates the TGF‐β/SMAD3 pathway, driving epithelial‐mesenchymal transition and fibrosis, which ultimately facilitates crystal ...
Kai Liu +16 more
wiley +1 more source
Obsidian deposits in the central Balkans? Tested against archaeological evidence [PDF]
Finds of obsidian artefacts on sites distant from the presumed primary source have often received a romantic note in the history of archaeology manifested in the idea about local exploitation as a form of procurement and archaeologists’ search for as yet
Tripković Boban
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ABSTRACT Class Switch Recombination (CSR) is essential for generating high‐affinity antibody isotypes from IgM during adaptive humoral responses. Despite well‐established roles for various transcription factors, whether CSR is subject to dedicated post‐transcriptional control represents a significant gap in knowledge.
Siyuan Sun +19 more
wiley +1 more source
Differences in the selection of raw materials at the site of Polgár-Csőszhalom, northeast Hungary
Chipped stone artefacts played an important role in sustaining human life not just in the Palaeolithic, but in the Neolithic period also. The raw material preferences and choices became more indicative as more complex settlements and societies emerged ...
Norbert Faragó
doaj

