Results 51 to 60 of about 730 (259)
Mechanical Activation of Piezo1 Drives Osteoarthritis Through Kdm5c‐Mediated Epigenetic Silencing
Advanced Science, EarlyView.Excessive mechanical stress activates Piezo1, triggering Ca2+‐dependent cytoskeletal forces that deform the nucleus and reduce H3K4me3. Kdm5c demethylates H3K4me3 at Col2a1 and Runx3 promoters. Kdm5c knockout rescues degradation. Repurposed telmisartan directly inhibits Kdm5c, blocking this axis and showing disease‐modifying efficacy in mouse OA models
Tianyou Kan +13 more
wiley +1 more source
Preliminary analysis of the Late Natufian ground stone from Shubayqa 1, Jordan
Journal of Lithic Studies, 2016 Shubayqa 1 is a newly identified early and late Natufian site in the harra desert of northeastern Jordan. In addition to buildings, and rich chipped stone, faunal, and botanical assemblages, the site has produced a large collection of ground stone tools.
Patrick Nørskov Pedersen +2 more
doaj +1 more source
Advanced Science, EarlyView.A facile laser‐induced graphene–silver nanocomposite strategy enables ultrathin epidermal electrodes with low impedance, high conductivity, and excellent mechanical robustness. The porous LIG–Ag conductive network mechanically interlocked with SEBS provides stable, motion‐resistant biopotential monitoring, enabling high‐fidelity ECG, EMG, and EEG ...
Jiuqiang Li +6 more
wiley +1 more source
Advanced Science, EarlyView.Adult stem cell therapy requires more than high in vitro potency. This review proposes a systems framework in which cell‐intrinsic programs, instructive microenvironmental cues, and pre‐/post‐delivery engineering are co‐designed under standardized translational rules.
Soo‐Rim Kim +2 more
wiley +1 more source
Tyragetia, 2014 The article publishes the materials from the surface of a new Late Tripolian settlement in the Middle Dniester region. Apart from pottery, the abundance of stone implements is quite remarkable.
Stanislav Ţerna
doaj
Evidence of daily life inside the EBA I defence system at Hacılar Büyük Höyük (Burdur–Turkey)
Българско е-Списание за Археология, 2021 Excavations at Hacılar Büyük Höyük, which is located 27 km to the southwest of Burdur, began in 2011 under my direction and are still in progress. The pre-planned, “sawtooth”-shaped defence system surrounds the settlement along the western slope like a ...
Gülsün Umurtak
doaj
Quality Thresholds for Angiogenesis Under Acoustic Manipulation in Engineered Vascular Tissues
Advanced Science, EarlyView.Defined biological and physical quality thresholds achieved through acoustic manipulation regulate cellular alignment and spatial organization, promoting self‐assembling vasculature, extracellular matrix deposition, and angiogenic responses, thereby establishing critical acoustic patterning requirements for engineered vascular tissue development in ...
Oscar O'Dwyer Lancaster‐Jones +5 more
wiley +1 more source
Halide Perovskite: A Rich Source of Thermal Insulator
Advanced Science, EarlyView.Halide perovskites exhibit ultralow thermal conductivity driven by intrinsic lattice softness and strong anharmonicity, falling below conventional defect‐engineering limits. Weak metavalent bonding, A‐site rattling, and dynamic octahedral tilting drive phonon scattering to the Ioffe–Regel limit, where wave‐like tunneling replaces particle‐like ...
Haolin Ye +3 more
wiley +1 more source
The Cretan Mesolithic in context: new data from Livari Skiadi (SE Crete)
Documenta Praehistorica, 2016 Investigations at Livari (south-eastern Crete) produced a small Mesolithic chipped stone assemblage, whose techno-typological characteristics situate it within an ‘early Holocene Aegean island lithic tradition’ (9000–7000 cal BC).
Tristan Carter +3 more
doaj +1 more source
Scottish Archaeological Internet ReportsAt North Barr River, Morvern, inspection of forestry planting mounds on a raised beach terrace identified a chipped stone assemblage associated with upcast deposits containing charcoal. An archaeological evaluation of the site, funded by Forestry Commission Scotland, sought to better understand the extent and character of this Mesolithic and later ...
openaire +1 more source