Results 31 to 40 of about 11,580 (259)

Chiral microenvironment-responsive mesoporous silica nanoparticles for delivering indometacin with chiral recognition function

Materials & Design, 2022
The purpose of this study was to investigate the potential chiral recognition functions induced by two kinds of novel chiral microenvironment-responsive mesoporous silica nanoparticles (CMR-L-MSN and CMR-D-MSN) for the oral delivery of the poorly water ...
Kaijun Gou, Xianmou Guo, Yuxin Wang, Yumei Wang, Zhentao Sang, Shuangshuang Ma, Yingyu Guo, Linlin Xie, Sanming Li, Heran Li   +9 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

The recognition of Z-DNA by chiral helicene [PDF]

Nucleic Acids Symposium Series, 2004
Enantiomeric helicenes of (P)-A and (M)-A were synthesized. The binding of the helicenes to B- and Z-DNA was studied quantitatively by CD, equilibrium dialysis, and fluorescence spectroscopy. Enantiomeric (P)-A not only bound selectively to Z-DNA, but also effectively converted the B-DNA conformation to Z-DNA.
Yan, Xu, Hiroshi, Sugiyama, Kazuhiko, Tanaka, Hideji, Osuga   +3 more
openaire   +2 more sources

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Visualization of enantiorecognition by excited-state conformation modulation

Nature Communications
Chiral purity is crucial in life sciences, emphasizing the importance of precise enantiomeric identification and the development of analytical techniques.
Zizhao Huang, Ying Hu, Jie Sun, Zhenyi He, Tao Jiang, He Tian, Xiang Ma   +6 more
doaj   +1 more source

Influence of Geometric Design on Mechanical Performance of Auxetic Metastructure

Advanced Engineering Materials, EarlyView.
Strategic geometric reinforcement transforms auxetic performance. This study evaluates 3D‐printed arrowhead metastructures, revealing that a modified design with local ring reinforcement suppresses premature failure to achieve superior energy absorption and structural efficiency.
Muhammad Gulzari, Supharoek Sornsomrit, Muhammad Ayaz Akbar, Stephan Rudykh   +3 more
wiley   +1 more source

Design and Analysis of Compression–Torsion Coupling Metamaterials Using the Golden Section Method

Advanced Engineering Materials, EarlyView.
A novel compression–torsion metamaterial is engineered using inclined rods and symmetry breaking. To optimize its torsional performance, the golden section method is employed. The mechanical response of the metamaterial is validated through both numerical analysis and experimental validation.
Amirhossein Hassani, Sara Bagherifard
wiley   +1 more source

A chiral helical self-assembly for electrochemical recognition of tryptophan enantiomers

Electrochemistry Communications, 2019
Molecular self-assembly has been regarded as a promising strategy for the construction of chiral sensing devices. Here, (1R,2R)-N,N-didodecylcyclohexane-1,2-dicarboxamide (DDC) was synthesized and then self-assembled in alcohol, and a chiral helical ...
Jiapei Yang, Datong Wu, Gao-Chao Fan, Linzheng Ma, Yongxin Tao, Yong Qin, Yong Kong   +6 more
doaj   +1 more source

Emergent Topological Magnons and Thermal Hall Effect in 2D Filling‐Enforced Fully Compensated Ferrimagnets

Advanced Functional Materials, EarlyView.
Schematic illustration of ferroelectric‐intercalation‐driven transitions in magnetic configurations and magnonic topological phases, together with the symmetry relations of magnonic Berry curvature. ABSTRACT Magnons in collinear magnets with vanishing net magnetization offer unique advantages for spin transport, including ultrafast dynamics and ...
Yingxi Bai, Bo Yuan, Zhenzhou Guo, Jian Zhang, Ying Dai, Baibiao Huang, Xiaotian Wang, Chengwang Niu, Gang Zhang   +8 more
wiley   +1 more source

Application of MOFs in asymmetric catalysis

上海师范大学学报. 自然科学版, 2023
So far, metal-organic frameworks(MOFs) have been developed in many fields, including gas adsorption, catalysis, and other directions. In recent years, due to the rapid development of asymmetric catalysis, chiral MOFs in stereoselective catalysis has ...
ZHANG Xiang, TAN Chunxia, LIN Jingrong
doaj   +1 more source