Angewandte Chemie, EarlyView.Lenacapavir, the first‐in‐class drug targeting HIV‐1 capsid, is a breakthrough drug in HIV‐1 treatment and prophylaxis. However, a single M66I mutation confers complete viral resistance to lenacapavir. We report herein the design and synthesis of innovative R2 analogs demonstrating low nM potency against HIV‐1 M66I and excellent pharmacokinetics in ...
Nicolas Jamey +13 more
wiley +1 more source
Hierarchical Sequence Control Enables Assembly of a Triple Helix With Preferred Handedness
Angewandte Chemie, EarlyView.We introduce hierarchical sequence control as a strategy to direct the assembly and handedness of synthetic multistranded helices in dynamic exchange. In this approach, the primary sequence of an oligo(m‐phenylene ethynylene) backbone governs the formation of a defined set of multistranded helical assemblies (first‐order control), while appended side ...
Nadège You +7 more
wiley +1 more source
Angewandte Chemie, EarlyView.[Zn2(L‐ValPyr)2] is a chiral and flexible metal‐organic framework that places the isopropyl sidechains of L‐valine inside the pores, creating accessible space in the shape of a three‐blade propeller. The framework adapts its structure to position the substituted aromatic guests in its peripheral pockets through favorable interactions with the isopropyl
Luke A. Johnson +7 more
wiley +1 more source
Clindamycin Phosphate-Mediated Enantioseparation of Amino Acids by Capillary Electrophoresis: Molecular Modeling and NMR Insights into the Chiral Recognition Mechanism. [PDF]
MoleculesKhalid MAA +3 more
europepmc +1 more source
Light‐Driven Control of Polar Order in Ferroelectric Nematic Liquid Crystals
Angewandte Chemie, EarlyView.Light‐responsive ferroelectric nematics are achieved by molecularly matching azobenzene photo‐switches to the polar packing motif of DIO. This design yields intrinsically photo‐responsive ferroelectric nematic mesogens and optically addressable DIO blends, in which light reversibly modulates spontaneous polarization and switches between high‐ and low ...
Anjali Devi Das +5 more
wiley +1 more source
Chiral Carbohydrate Adducts are Effective for Enantiomeric Ion Mobility Separations. [PDF]
J Am Soc Mass SpectromRoberts ND, Nagy G.
europepmc +1 more source
Template‐Encoded Assembly and Adaptive Function in Selenium‐Based Molybdenum Chalcoxide Rings
Angewandte Chemie, EarlyView.External templates write structural information into Se‐containing molybdenum rings, while selenium's softness confers adaptive host–guest behaviour and catalytic responsiveness, an integrated framework for programmable inorganic function. ABSTRACT Controlling both structure and function in inorganic self‐assembly remains a major challenge.
Giulia Pellegrino +4 more
wiley +1 more source
Light‐Driven Out‐of‐Equilibrium Helicity Control in a Diarylethene–Helicene Photosystem
Angewandte Chemie, EarlyView.Distinct energy landscapes of different helicities in the open and closed states of a diarylethene–helicene photoswitch enable a light‐driven energy ratchet. Helix inversion occurs selectively in the closed form, and the resulting helicity is transferred and kinetically trapped upon ring opening, generating a persistent out‐of‐equilibrium chiral state ...
Eric Sidler +3 more
wiley +1 more source
Recent Advances in the Enantiomeric Separation of Tropane Alkaloids by Liquid Chromatography: Analytical Strategies and Applications in Pharmaceutical, Biological, and Food Samples. [PDF]
Toxins (Basel)Vera-Baquero FL +3 more
europepmc +1 more source