Chitin induces accumulation in tissue of innate immune cells associated with allergy [PDF]
Nature, 2007 Allergic and parasitic worm immunity is characterized by infiltration of tissues with interleukin (IL)-4- and IL-13-expressing cells, including T-helper-2 cells, eosinophils and basophils. Tissue macrophages assume a distinct phenotype, designated alternatively activated macrophages.
Tiffany A, Reese +6 more
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TLR-2 and IL-17A in Chitin-Induced Macrophage Activation and Acute Inflammation [PDF]
The Journal of Immunology, 2008 Abstract Chitin is a ubiquitous polysaccharide in fungi, insects, and parasites. To test the hypothesis that chitin is an important immune modulator, we characterized the ability of chitin fragments to regulate murine macrophage cytokine production in vitro and induce acute inflammation in vivo. In this study, we show that chitin is a
Carla A, Da Silva +4 more
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Scientific Reports, 2021 Exposure to various antigens derived from house dust mites (HDM) is considered to be a risk factor for development of certain allergic diseases such as atopic asthma, atopic dermatitis, rhinitis and conjunctivitis.
Ken Arae +14 more
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Chitin induces upregulation of B7‐H1 on macrophages and inhibits T‐cell proliferation [PDF]
European Journal of Immunology, 2010 AbstractChitin is a highly abundant glycopolymer, which serves as structural component in fungi, arthropods and crustaceans but is not synthesized by vertebrates. However, vertebrates express chitinases and chitinase‐like proteins, some of which are induced by infection with helminths suggesting that chitinous structures may be targets of the immune ...
Claudia J, Wagner +3 more
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A structural and biochemical model of processive chitin synthesis [PDF]
, 2014 Chitin synthases (CHS) produce chitin, an essential component of the fungal cell wall. The molecular mechanism of processive chitin synthesis is not understood, limiting the discovery of new inhibitors of this enzyme class.
Ferenbach, Andrew T. +3 more
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Arabidopsis ubiquitin ligase PUB12 interacts with and negatively regulates Chitin Elicitor Receptor Kinase 1 (CERK1). [PDF]
PLoS ONE, 2017 In Arabidopsis, fungal chitin is recognized as a pathogen-associated molecular pattern (PAMP) by the chitin receptor complex containing the lysin-motif (LysM) receptor-like kinases CERK1 and LYK5.
Koji Yamaguchi +4 more
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Chitin nanofiber elucidates the elicitor activity of polymeric chitin in plants
Frontiers in Plant Science, 2015 Chitin, an N-acetyl-D-glucosamine polymer, is a component of fungal cell walls and a microbe/pathogen-associated molecular pattern that elicits plant defense responses.
Mayumi eEgusa +7 more
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Nanostructural organization of naturally occurring composites - part II: silica-chitin-based biocomposites [PDF]
, 2012 Investigations of the micro- and nanostructures and chemical composition of the sponge skeletons as examples for natural structural biocomposites are of fundamental scientific relevance.
Worch, Hartmut +11 more
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Effect of the degree of acetylation on the physicochemical properties of α-chitin nanofibers [PDF]
, 2020 Available online 27 March 2020.The effective utilization of abundant α-chitin resources for materials engineering applications requires methods for controlling the physicochemical properties of α-chitin nanofiber (NF) dispersions.
MACHIDA, Junnosuke +2 more
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Arabidopsis CPK5 Phosphorylates the Chitin Receptor LYK5 to Regulate Plant Innate Immunity
Frontiers in Plant Science, 2020 Chitin, a major component of the fungal cell wall, triggers plant innate immunity in Arabidopsis via a receptor complex including two major lysin motif receptor-like kinases, AtLYK5, and AtCERK1.
Congcong Huang +4 more
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