Preparation and Primary Bioactivity Evaluation of Novel Water-Soluble Curcumin-Loaded Polymeric Micelles Fabricated with Chitooligosaccharides and Pluronic F-68 [PDF]
Pharmaceutics, 2023 Curcumin (CU) is a bioactive compound extracted from turmeric and has various advantages. However, the benefit of CU is limited by its low water solubility (11 ng/mL).
Pattarachat Ingrungruengluet +5 more
doaj +2 more sources
Marine Drugs, 2018 The methods to obtain chitooligosaccharides are tightly related to the physicochemical properties of the end products. Knowledge of these physicochemical characteristics is crucial to describing the biological functions of chitooligosaccharides ...
Florentina Niuris Acosta Contreras +2 more
exaly +3 more sources
Effect of Chitooligosaccharides on TLR2/NF-κB Signaling in LPS-Stimulated RAW 264.7 Macrophages [PDF]
MoleculesChitooligosaccharides (COSs), degraded products of chitosan or chitin, are attracting growing interest owing to their low degree of polymerization (DP), high solubility, and prominent anti-inflammatory activity.
Mengting Zhao +4 more
doaj +2 more sources
Influence of Cowpea Plants on Soil Bacterial Community and Soil Quality: Effects of the Rhizosphere [PDF]
Plant-Environment Interactions, Volume 7, Issue 3, June 2026.ABSTRACT Cowpea (Vigna Unguiculata), a vital legume for suitable agriculture and food security in sub‐Saharan Africa, plays a crucial role in improving soil health through intricate plant‐microbe interactions in the rhizosphere. This review synthesizes current knowledge on the microbial interactions in the rhizosphere, focusing on soil health ...
Motlagomang Khantsi +1 more
wiley +2 more sources
Computer‐Based Design to Improve Bacillus thuringiensis Chitinase for Industrial Applications [PDF]
ChemistryOpen, Volume 15, Issue 4, April 2026.Hotspot‐guided mutagenesis identifies Gly291 as a key catalytic determinant in Bacillus thuringiensis chitinase. Substitution with alanine improves substrate accommodation and lowers the activation barrier by ∼47%, reducing it from 94.66 to 49.83 kcal/mol. Structural integrity is retained while catalytic efficiency is enhanced, demonstrating a rational
S. G. Sree Agash +5 more
wiley +2 more sources
Chitooligosaccharides suppress airway inflammation, fibrosis, and mucus hypersecretion in a house dust mite-induced allergy model [PDF]
Frontiers in AllergyBackgroundRespiratory allergy is a serious respiratory disorder characterized by inflammation, mucus hypersecretion, and airway tissue sclerosis. Disruption of the T helper 1 (Th1) and T helper 2 (Th2) immune systems by stimuli induced by house dust ...
Yun-Ho Kim +3 more
doaj +2 more sources
The regulatory effect of chitooligosaccharides on islet inflammation in T2D individuals after islet cell transplantation: the mechanism behind Candida albicans abundance and macrophage polarization [PDF]
Gut MicrobesIslet cell transplantation (ICT) represents a promising therapeutic approach for addressing diabetes mellitus. However, the islet inflammation during transplantation significantly reduces the surgical outcome rate, which is related to the polarization of
Yayu Zhang +5 more
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Molecules, 2021 In this paper, chitooligosaccharides in different salt forms, such as chitooligosaccharide lactate, citrate, adipate, etc., were prepared by the microwave method.
Ronge Xing +9 more
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Marine Drugs, 2022 Catharanthus roseus (L.) G. Don is a plant belonging to the genus Catharanthus of the Apocynaceae family. It contains more than one hundred alkaloids, of which some exhibit significant pharmacological activities.
Wenzhu Tang +3 more
doaj +1 more source
Molecules, 2021 Chitooligosaccharides exhibit several biomedical activities, such as inflammation and tumorigenesis reduction in mammals. The mechanism of the chitooligosaccharides’ formation in vivo has been, however, poorly understood. Here we report that mouse acidic
Satoshi Wakita +14 more
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