Potential Medical Applications of Chitooligosaccharides
Polymers, 2022 Chitooligosaccharides, also known as chitosan oligomers or chitooligomers, are made up of chitosan with a degree of polymerization (DP) that is less than 20 and an average molecular weight (MW) that is lower than 3.9 kDa.
S. Anil
semanticscholar +3 more sources
Snustorr Defines Cuticle Elasticity in Drosophila melanogaster [PDF]
Archives of Insect Biochemistry and Physiology, Volume 121, Issue 3, March 2026.Sir Wigglesworth postulated that insect cuticle hardening depended on the incorporation of lipids into the upper parts of the cuticle. We show that the delivery of these lipids needed for cuticle hardening requires the ABC transporter Snu in the fruit fly Drosophila melanogaster larva.
Alexander Kovalev +2 more
wiley +2 more sources
Computer‐Based Design to Improve Bacillus thuringiensis Chitinase for Industrial Applications [PDF]
ChemistryOpen, Volume 15, Issue 4, April 2026.Hotspot‐guided mutagenesis identifies Gly291 as a key catalytic determinant in Bacillus thuringiensis chitinase. Substitution with alanine improves substrate accommodation and lowers the activation barrier by ∼47%, reducing it from 94.66 to 49.83 kcal/mol. Structural integrity is retained while catalytic efficiency is enhanced, demonstrating a rational
S. G. Sree Agash +5 more
wiley +2 more sources
Structural insights into glycan recognition by plant immune receptors: a comparative perspective with animal innate immune systems [PDF]
The Plant Journal, Volume 126, Issue 1, April 2026.SUMMARY Pattern recognition receptors (PRRs) function across diverse eukaryotic organisms as a powerful surveillance system to perceive danger signals and to trigger specific adaptive responses. This complex receptor network constitutes the first layer of perception of the innate immune system of plants and mammals.
Gonzalo Vílchez‐Pinto +4 more
wiley +2 more sources
Effect of Chitooligosaccharides on TLR2/NF-κB Signaling in LPS-Stimulated RAW 264.7 Macrophages [PDF]
MoleculesChitooligosaccharides (COSs), degraded products of chitosan or chitin, are attracting growing interest owing to their low degree of polymerization (DP), high solubility, and prominent anti-inflammatory activity.
Mengting Zhao +4 more
doaj +2 more sources
A review of the immune activity of chitooligosaccharides
Food Science and Technology, 2023 Under the influence of the COVID-19, people's awareness of physical health and immunity has increased significantly. Chitooligosaccharide is an oligomer of β-(1, 4)-linked D-glucosamine, furthermore, is one of the most widely studied immunomodulators ...
Yuan Wang +8 more
semanticscholar +3 more sources
Bioproduction of Chitooligosaccharides: Present and Perspectives [PDF]
Marine Drugs, 2014 Chitin and chitosan oligosaccharides (COS) have been traditionally obtained by chemical digestion with strong acids. In light of the difficulties associated with these traditional production processes, environmentally compatible and reproducible ...
Woo-Jin Jung, Ro-Dong Park
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Chitooligosaccharides suppress airway inflammation, fibrosis, and mucus hypersecretion in a house dust mite-induced allergy model [PDF]
Frontiers in AllergyBackgroundRespiratory allergy is a serious respiratory disorder characterized by inflammation, mucus hypersecretion, and airway tissue sclerosis. Disruption of the T helper 1 (Th1) and T helper 2 (Th2) immune systems by stimuli induced by house dust ...
Yun-Ho Kim +3 more
doaj +2 more sources
The regulatory effect of chitooligosaccharides on islet inflammation in T2D individuals after islet cell transplantation: the mechanism behind Candida albicans abundance and macrophage polarization [PDF]
Gut MicrobesIslet cell transplantation (ICT) represents a promising therapeutic approach for addressing diabetes mellitus. However, the islet inflammation during transplantation significantly reduces the surgical outcome rate, which is related to the polarization of
Yayu Zhang +5 more
doaj +2 more sources
Advances in chitooligosaccharides chemical modifications [PDF]
Biopolymers, 2021 AbstractChitooligosaccharides (COS) differ from chitosan by their molar mass: those of COS are defined to be lower than 20 kg mol−1. Their functionalization is widely described in the literature and leads to the introduction of new properties that broaden their application fields.
Chapelle, Camille +4 more
openaire +2 more sources