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Preparation and biological activities of chitosan oligosaccharides
Trends in Food Science & Technology, 2021Abstract Background Chitosan oligosaccharides (COSs) are the degraded products prepared from the deacetylation and depolymerization of chitin or chitosan using physical, chemical, or enzymatic hydrolysis. In comparison to chitosan and chitin, COS, the hydrolyzed form, has lower molecular weight, lower degree of polymerization (DP), higher degree of ...
Gunsriwiang Benchamas +3 more
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Antioxidant activity of N-carboxymethyl chitosan oligosaccharides
Bioorganic & Medicinal Chemistry Letters, 2008Three N-carboxymethyl chitosan oligosaccharides (N-CMCOSs) with different degrees of substitution (NA: 0.28, NB: 0.41, and NC: 0.54, respectively) were prepared by the control of the amount of glyoxylic acid in the etherification process of chitosan oligosaccharide (COS).
Tao, Sun +3 more
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Characterization of novel galactosylated chitin-oligosaccharides and chitosan-oligosaccharides
International Dairy Journal, 2014This study determined whether chitin-oligosaccharides and chitosan-oligosaccharides (COS) are suitable acceptor carbohydrates for the LacLM-type β-galactosidase of Lactobacillus plantarum. Enzymatic reactions were carried out with lactose as galactosyl-donor and chitinbiose (N,N′-diacetyl chitobiose), chitintriose (N,N′N″-triacetyl chitotriose) or a ...
Black, Brenna A. +5 more
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Advances in characterisation and biological activities of chitosan and chitosan oligosaccharides
Food Chemistry, 2016Chitosan and chitosan oligosaccharides (COS) have been reported to possess various biomedical properties, including antimicrobial activities, immuno-enhancing effects, and anti-tumour activities. COS have attracted considerable interest due to their physicochemical properties, and potential applications in the food and pharmaceutical industries ...
Pan, Zou +6 more
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International Journal of Biological Macromolecules, 2022
Chitosan (CTS)/chitosan oligosaccharide (COS) and whey protein isolate (WPI) have been frequently used as food supplements, but notably, the interaction between the carbohydrate and the protein may affect the digestibility of protein. Thus, the present study focused on effects of the interaction between CTS/COS and WPI on the protein digestibility.
Linlin, Wang +6 more
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Chitosan (CTS)/chitosan oligosaccharide (COS) and whey protein isolate (WPI) have been frequently used as food supplements, but notably, the interaction between the carbohydrate and the protein may affect the digestibility of protein. Thus, the present study focused on effects of the interaction between CTS/COS and WPI on the protein digestibility.
Linlin, Wang +6 more
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Chitosan oligosaccharide: Biological activities and potential therapeutic applications
Pharmacology & Therapeutics, 2017Chitosan oligosaccharide (COS) is an oligomer of β-(1➔4)-linked d-glucosamine. COS can be prepared from the deacetylation and hydrolysis of chitin, which is commonly found in the exoskeletons of arthropods and insects and the cell walls of fungi. COS is water soluble, non-cytotoxic, readily absorbed through the intestine and mainly excreted in the ...
Chatchai, Muanprasat +1 more
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Cinnamyl alcohol modified chitosan oligosaccharide for enhancing antimicrobial activity
Food Chemistry, 2020The present study aims at synthesizing and in vitro antibacterial activity evaluation of chitosan oligosaccharide (COS) modified by Cinnamyl alcohol (Cin) onto the OH position of COS. Three different degrees of substitution (DS) COS-O-Cin1-3 were synthesized by changing different molar ratios of COS to Cin.
Lin, Yue +5 more
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Preparation and characterisation of chitosans with oligosaccharide branches
Carbohydrate Research, 2002The trimer 2-acetamido-2-deoxy-D-glucopyranosyl-beta-(1-->4)-2-acetamido-2-deoxy-D-glucopyranosyl-beta-(1-->4)-2,5-anhydro-D-mannofuranose (A-A-M) was reductively N-alkylated onto a fully de-N-acetylated chitosan (F(A)
Kristoffer, Tømmeraas +5 more
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Genotoxicity evaluation of stearic acid grafted chitosan oligosaccharide nanomicelles
Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2013Stearic acid grafted chitosan oligosaccharide (CSO-SA) nanomicelles could be promptly internalized into cancer cells; therefore, it is regarded as a promising drug carrier for cancer therapy. However, the toxicity of CSO-SA is not clear. In the present study, the genotoxic effects of CSO-SA nanomicelles (with high substitution degree of SA, 42.6±3.8 ...
Peng, Hu +11 more
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Chitosan oligosaccharides alleviate PM2.5-induced lung inflammation in rats
Environmental Science and Pollution Research, 2018Air pollution of particulate matter (PM), especially PM2.5, has become a major public health problem in China. Exploration of therapeutic and preventive measures against PM2.5 toxicity is of practical significance. The aim of this study was to examine the inhibitory effects of chitosan oligosaccharides (COS) on PM2.5-induced lung inflammation in rats ...
Yingzheng, Zhao +4 more
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