Penicillin kills chlamydia following the fusion of bacteria with Lysosomes and prevents genital inflammatory lesions in C. muridarum-infected mice [PDF]
The obligate intracellular bacterium Chlamydia exists as two distinct forms. Elementary bodies (EBs) are infectious and extra-cellular, whereas reticulate bodies (RBs) replicate within a specialized intracellular compartment termed an ‘inclusion ...
Delarbre, C.+7 more
core +14 more sources
Infection with the obligate intracellular bacterium Chlamydia trachomatis is the most common bacterial sexually transmitted disease worldwide. Since no vaccine is available to date, antimicrobial therapy is the only alternative in C.
Kensuke Shima+16 more
doaj +1 more source
The persistence of chlamydial inclusions in clinically quiescent trachoma.
Most of the trachoma patients seen at the Guinness Eye Clinic in Kaduna, Northern Nigeria today are in the healed or quiescent stages of evolution and disease intensity is largely trivial. A significant proportion however, seem to have recrudescence of the active stages, a phenomenon that is usually attributed to reinfection.
Babalola Oe, Bage Sd
openalex +2 more sources
Host Cell Amplification of Nutritional Stress Contributes To Persistence in Chlamydia trachomatis
Persistence, a viable but non-replicating growth state, has been implicated in diseases caused by Chlamydia trachomatis. Starvation of distinct nutrients produces a superficially similar persistent state, implying convergence on a common intracellular ...
Nick D. Pokorzynski+2 more
doaj +1 more source
Laboratory diagnosis of persistent human chlamydial infection [PDF]
Diagnostic assays for persistent chlamydial infection are much needed to conduct high-quality, large-scale studies investigating the persistent state in vivo, its disease associations and the response to therapy. Yet in most studies the distinction between acute and persistent infection is based on the interpretation of the data obtained by the assays ...
Mirja ePuolakkainen, Mirja ePuolakkainen
openaire +5 more sources
Chlamydial infection of the gastrointestinal tract: a reservoir for persistent infection [PDF]
The mechanism by which chlamydiae persist in vivo remains undefined; however, chlamydiae in most animals persist in the gastrointestinal tract (GI) and are transmitted via the fecal-oral route. Oral infection of mice with Chlamydia muridarum was previously shown to establish a long-term persistent infection in the GI tract. In this study, BALB/c, DBA/2,
Laxmi Yeruva+4 more
openaire +2 more sources
Analysis of polymorphic membrane protein expression in cultured cells Identifies PmpA and PmpH of Chlamydia psittaci as candidate factors in pathogenesis and immunity to infection [PDF]
The polymorphic membrane protein (Pmp) paralogous families of Chlamydia trachomatis, Chlamydia pneumoniae and Chlamydia abortus are putative targets for Chlamydia vaccine development. To determine whether this is also the case for Pmp family members of C.
Bavoil, Patrik+7 more
core +2 more sources
Chlamydial infection from outside to inside [PDF]
Chlamydia are obligate intracellular bacteria, characterized by a unique biphasic developmental cycle. Specific interactions with the host cell are crucial for the bacteria's survival and amplification because of the reduced chlamydial genome.
Gitsels, Arlieke+2 more
core +2 more sources
Chlamydia trachomatis is an obligate intracellular bacterial pathogen that causes blinding trachoma and sexually transmitted disease afflicting hundreds of millions of people globally. A fundamental but poorly understood pathophysiological characteristic
Chunfu Yang+11 more
doaj +1 more source
Chlamydiosis of dogs and cats in modern cities [PDF]
The aim of the research was to conduct an in-depth analysis of the investigation of chlamydial infections occurred in cats and dogs in Kyiv during the last 10 years.
Nedosekov Vitaliy+6 more
doaj +1 more source