Results 21 to 30 of about 365,054 (191)

Chlamydial Persistence: beyond the Biphasic Paradigm [PDF]

Infection and Immunity, 2004
The chlamydiae are an evolutionarily distinct group of eubacteria sharing an obligate intracellular lifestyle and a unique developmental cycle that has been well characterized under favorable cell culture conditions. This cycle begins when infectious, metabolically inert elementary bodies (EB)
Hogan, Richard, Mathews, Sarah, Mukhopadhyay, Sanghamitra, Summersgill, James, Timms, Peter   +4 more
openaire   +3 more sources

Host Cell Amplification of Nutritional Stress Contributes To Persistence in Chlamydia trachomatis

mBio, 2022
Persistence, a viable but non-replicating growth state, has been implicated in diseases caused by Chlamydia trachomatis. Starvation of distinct nutrients produces a superficially similar persistent state, implying convergence on a common intracellular ...
Nick D. Pokorzynski, Monisha R. Alla, Rey A. Carabeo   +2 more
doaj   +1 more source

Chlamydial infection of the gastrointestinal tract: a reservoir for persistent infection [PDF]

Pathogens and Disease, 2013
The mechanism by which chlamydiae persist in vivo remains undefined; however, chlamydiae in most animals persist in the gastrointestinal tract (GI) and are transmitted via the fecal-oral route. Oral infection of mice with Chlamydia muridarum was previously shown to establish a long-term persistent infection in the GI tract. In this study, BALB/c, DBA/2,
Laxmi, Yeruva, Nicole, Spencer, Anne K, Bowlin, Yin, Wang, Roger G, Rank   +4 more
openaire   +2 more sources

Chlamydia trachomatis Plasmid Gene Protein 3 Is Essential for the Establishment of Persistent Infection and Associated Immunopathology

mBio, 2020
Chlamydia trachomatis is an obligate intracellular bacterial pathogen that causes blinding trachoma and sexually transmitted disease afflicting hundreds of millions of people globally. A fundamental but poorly understood pathophysiological characteristic
Chunfu Yang, Laszlo Kari, Lei Lei, John H. Carlson, Li Ma, Claire E. Couch, William M. Whitmire, Kevin Bock, Ian Moore, Christine Bonner, Grant McClarty, Harlan D. Caldwell   +11 more
doaj   +1 more source

Modulation of the Chlamydia trachomatis In vitro transcriptome response by the sex hormones estradiol and progesterone

BMC Microbiology, 2011
Background Chlamydia trachomatis is a major cause of sexually transmitted disease in humans. Previous studies in both humans and animal models of chlamydial genital tract infection have suggested that the hormonal status of the genital tract epithelium ...
Symonds Ian, Latter Joanna, Beagley Kenneth, Wan Charles, Amirshahi Ashkan, Timms Peter   +5 more
doaj   +1 more source

New insights into a persistent problem — chlamydial infections [PDF]

Journal of Clinical Investigation, 2003
Tissue tropism of clinical ocular and genital Chlamydia trachomatis strains is shown to be linked to the tryptophan synthase genotype. It is suggested that, in the presence of IFN-gamma, which depletes available tryptophan, there exist unique host-parasite interactions that may contribute to persistent chlamydial infection.
openaire   +2 more sources

Conjunctival FOXP3 expression in trachoma: do regulatory T cells have a role in human ocular Chlamydia trachomatis infection? [PDF]

, 2006
BACKGROUND: Trachoma, caused by ocular infection with Chlamydia trachomatis, remains the leading infectious cause of blindness and in 2002 was responsible for 3.6% of total global blindness.
Faal Nkoyo, Jeffries, David, Sarr Isatou, Joof Hassan, Nkoyo Faal, David Jeffries, Laye Mass, Martin J Holland, Robin L Bailey, Bailey Robin L, Bailey, Robin L, Holland, Martin J, Jeffries David, Joof, Hassan, Laye, Mass, Holland Martin J, Hassan Joof, Mass Laye, Mabey David C. W, Sarr, Isatou, David C W Mabey, Faal, Nkoyo, Isatou Sarr, Mabey, David CW   +23 more
core   +1 more source

Tryptophan depletion as a mechanism of gamma interferon-mediated chlamydial persistence [PDF]

Infection and Immunity, 1994
Previous studies have shown that the immune-regulated cytokine gamma interferon (IFN-gamma) activates host cells to restrict intracellular growth of the bacterial pathogen Chlamydia trachomatis by induction of the tryptophan-catabolizing enzyme indoleamine 2,3-dioxygenase (IDO).
W L, Beatty, T A, Belanger, A A, Desai, R P, Morrison, G I, Byrne   +4 more
openaire   +2 more sources

Chlamydiosis of dogs and cats in modern cities [PDF]

E3S Web of Conferences, 2021
The aim of the research was to conduct an in-depth analysis of the investigation of chlamydial infections occurred in cats and dogs in Kyiv during the last 10 years.
Nedosekov Vitaliy, Martyniuk Alexander, Stepanova Tatyana, Yustyniuk Valeria, Gulyukina Irina, Parshikova Anna, Drozdova Elena   +6 more
doaj   +1 more source

Fosmidomycin, an inhibitor of isoprenoid synthesis, induces persistence in Chlamydia by inhibiting peptidoglycan assembly.

PLoS Pathogens, 2019
The antibiotic, fosmidomycin (FSM) targets the methylerythritol phosphate (MEP) pathway of isoprenoid synthesis by inhibiting the essential enzyme, 1-deoxy-D-xylulose 5-phosphate reductoisomerase (Dxr) and is lethal to intracellular parasites and ...
Jessica A Slade, Mary Brockett, Raghuveer Singh, George W Liechti, Anthony T Maurelli   +4 more
doaj   +1 more source