Beta Lactamase-Producing Neisseria gonorrhoeae Alleviates Amoxicillin-Induced Chlamydial Persistence in a Novel in Vitro Co-Infection Model [PDF]
Current Research in Microbial Sciences, 2023 Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) cause most bacterial sexually transmitted infections (STIs) worldwide. Epidemiological studies have shown high percentages of co-infections with CT/NG and indicate that NG co-infection can ...
Nicole Borel +2 more
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Imbalanced Oxidative Stress Causes Chlamydial Persistence During Non-Productive Human Herpes Virus Co-Infection [PDF]
PLoS ONE, 2012 Both human herpes viruses and Chlamydia are highly prevalent in the human population and are detected together in different human disorders. Here, we demonstrate that co-infection with human herpes virus 6 (HHV6) interferes with the developmental cycle ...
Bhupesh Prusty, Thomas Rudel
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Porcine Epidemic Diarrhea Virus (PEDV) co-infection induced chlamydial persistence/stress does not require productive viral replication [PDF]
Frontiers in Cellular and Infection Microbiology, 2014 Chlamydiae may exist at the site of infection in an alternative replicative form, called the aberrant body (AB). AB are produced during a viable but non-infectious developmental state termed persistence or chlamydial stress.
Nicole eBorel, Robert V Schoborg
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Loss of PmpC in Chlamydia trachomatis leads to altered bacterial development and impaired recovery from IFNγ- and penicillin-induced stress [PDF]
Microbiology SpectrumChlamydia trachomatis is an obligate intracellular pathogen that can reversibly halt replication and developmental transitions in response to immunological or pharmacological stress, a phenomenon linked to chlamydial persistence.
Ailen N. Anna +10 more
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Frontiers in Cellular and Infection Microbiology, 2014 Chlamydia trachomatis, the most common bacterial sexually transmitted disease agent worldwide, enters a viable, non-dividing and non-infectious state (historically termed persistence and more recently referred to as the chlamydial stress response) when ...
Robert V Schoborg
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Genetic diversity of collaborative cross mice enables the establishment of a novel Chlamydia muridarum female genital tract infection model [PDF]
Infection and ImmunityChlamydial infection in women displays wide variation in bacterial burden, persistence, and risk of upper genital tract pathology, yet the host genetic factors underlying this heterogeneity remain poorly defined. We evaluated genital tract infection with
Toni Darville +11 more
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Comparative transcriptomics reveals genes commonly induced by distinct stressors in Chlamydia [PDF]
Infection and ImmunityChlamydia trachomatis is a leading cause of urogenital infections that can result in serious long-term complications. This obligate intracellular bacterium undergoes a biphasic developmental cycle alternating between the infectious elementary body and ...
Ronald Haines +3 more
doaj +2 more sources
Effect of tryptophan starvation on inclusion membrane composition and chlamydial-host interactions [PDF]
Infection and ImmunityChlamydia is an obligate intracellular bacterial pathogen that develops within a membrane-bound vacuole called an inclusion. Throughout its developmental cycle, Chlamydia modifies the inclusion membrane (IM) with type III secreted (T3S) membrane proteins,
Camille M. Riffaud-Widner +3 more
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Genomics and Chlamydial Persistence
mBio, 2019 Dan D. Rockey +2 more
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Iron limitation-induced modulation of transcription in Chlamydia trachomatis [PDF]
Scientific ReportsChlamydia trachomatis (C. trachomatis) is an obligate intracellular bacterial pathogen responsible for trachoma and sexually transmitted infections. Like other Chlamydiota members, such as Waddlia chondrophila, C.
Daniel Rodriguez Rozo +5 more
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