Reply to Rockey et al., “Genomics and Chlamydial Persistence
mBio, 2019 In addressing the letter to the editor by Rockey et al. (1), it is important to correct the statement “…patients can be colonized by C. trachomatis.” Chlamydia trachomatis does not colonize humans but infects them. The authors’ earlier paper (2) described five patients that had apparent reinfection and/or persistent infection over a few years despite ...
Deborah Dean +4 more
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Spatial constraints within the chlamydial host cell inclusion predict interrupted development and persistence [PDF]
BMC Microbiology, 2008 Background The chlamydial developmental cycle involves the alternation between the metabolically inert elementary body (EB) and the replicating reticulate body (RB).
Bavoil Patrik M +3 more
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Refinement of water-filtered infrared A (wIRA) irradiations of in vitro acute and persistent chlamydial infections. [PDF]
Journal of Photochemistry and Photobiology B: Biology, 2022 Water-filtered infrared A (wIRA) alone or in combination with visible light (VIS) exerts anti-chlamydial effects in vitro and in vivo in acute infection models.
Antonia Frohns +13 more
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The protease inhibitor JO146 demonstrates a critical role for CtHtrA for Chlamydia trachomatis reversion from penicillin persistence [PDF]
Frontiers in Cellular and Infection Microbiology, 2013 The Chlamydia trachomatis serine protease HtrA (CtHtrA) has recently been demonstrated to be essential during the replicative phase of the chlamydial developmental cycle.
Vanissa Abtina Ong +7 more
doaj +4 more sources
Golgi fragmentation and sphingomyelin transport to Chlamydia trachomatis during penicillin-induced persistence do not depend on the cytosolic presence of the chlamydial protease CPAF. [PDF]
PLoS ONE, 2014 Chlamydia grows inside a cytosolic vacuole (the inclusion) that is supplied with nutrients by the host through vesicular and non-vesicular transport. It is unclear in many respects how Chlamydia organizes this transport.
Stephanie Dille +6 more
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The danger signal adenosine induces persistence of chlamydial infection through stimulation of A2b receptors. [PDF]
PLoS ONE, 2009 Infections with intracellular bacteria such as chlamydiae affect the majority of the world population. Infected tissue inflammation and granuloma formation help contain the short-term expansion of the invading pathogen, leading also to local tissue ...
Matthew A Pettengill +2 more
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Mixed infections with
BMC Microbiology, 2010 Background Chlamydiae induce persistent infections, which have been associated with a wide range of chronic diseases in humans and animals. Mixed infections with Chlamydia and porcine epidemic diarrhea virus (PEDV) may result in generation of persistent ...
Kaiser Carmen +5 more
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Laboratory diagnosis of persistent human chlamydial infection [PDF]
Frontiers in Cellular and Infection Microbiology, 2013 Diagnostic assays for persistent chlamydial infection are much needed to conduct high-quality, large-scale studies investigating the persistent state in vivo, its disease associations and the response to therapy. Yet in most studies the distinction between acute and persistent infection is based on the interpretation of the data obtained by the assays ...
Mirja ePuolakkainen, Mirja ePuolakkainen
openaire +4 more sources
mBio, 2021 Infection with the obligate intracellular bacterium Chlamydia trachomatis is the most common bacterial sexually transmitted disease worldwide. Since no vaccine is available to date, antimicrobial therapy is the only alternative in C.
Kensuke Shima +16 more
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Damage/Danger Associated Molecular Patterns (DAMPs) Modulate Chlamydia pecorum and C. trachomatis Serovar E Inclusion Development In Vitro. [PDF]
PLoS ONE, 2015 Persistence, more recently termed the chlamydial stress response, is a viable but non-infectious state constituting a divergence from the characteristic chlamydial biphasic developmental cycle.
Cory Ann Leonard +2 more
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