Penicillin G-Induced Chlamydial Stress Response in a Porcine Strain of Chlamydia pecorum [PDF]
International Journal of Microbiology, 2016 Chlamydia pecorum causes asymptomatic infection and pathology in ruminants, pigs, and koalas. We characterized the antichlamydial effect of the beta lactam penicillin G on Chlamydia pecorum strain 1710S (porcine abortion isolate).
Cory Ann Leonard +2 more
doaj +8 more sources
The chlamydial periplasmic stress response serine protease cHtrA is secreted into host cell cytosol [PDF]
BMC Microbiology, 2011 Background The periplasmic High Temperature Requirement protein A (HtrA) plays important roles in bacterial protein folding and stress responses. However, the role of chlamydial HtrA (cHtrA) in chlamydial pathogenesis is not clear.
Flores Rhonda +5 more
doaj +3 more sources
Coordinated topoisomerase function shapes the fluoroquinolone response of Chlamydia trachomatis [PDF]
Microbiology SpectrumDNA supercoiling is essential for the developmental cycle of Chlamydia trachomatis, yet its role in shaping antibiotic responses remains poorly understood. We investigated how the fluoroquinolone moxifloxacin (Mox), a potent DNA gyrase inhibitor, affects
Andrew Terrebonne +5 more
doaj +2 more sources
Loss of PmpC in Chlamydia trachomatis leads to altered bacterial development and impaired recovery from IFNγ- and penicillin-induced stress [PDF]
Microbiology SpectrumChlamydia trachomatis is an obligate intracellular pathogen that can reversibly halt replication and developmental transitions in response to immunological or pharmacological stress, a phenomenon linked to chlamydial persistence.
Ailen N. Anna +10 more
doaj +2 more sources
Comparative transcriptomics reveals genes commonly induced by distinct stressors in Chlamydia [PDF]
Infection and ImmunityChlamydia trachomatis is a leading cause of urogenital infections that can result in serious long-term complications. This obligate intracellular bacterium undergoes a biphasic developmental cycle alternating between the infectious elementary body and ...
Ronald Haines +3 more
doaj +2 more sources
Host Cell Amplification of Nutritional Stress Contributes To Persistence in Chlamydia trachomatis
mBio, 2022 Persistence, a viable but non-replicating growth state, has been implicated in diseases caused by Chlamydia trachomatis. Starvation of distinct nutrients produces a superficially similar persistent state, implying convergence on a common intracellular ...
Nick D. Pokorzynski +2 more
doaj +1 more source
mBio, 2023 Gene transcription in bacteria is carried out by the multisubunit RNA polymerase (RNAP), which is composed of a catalytic core enzyme and a promoter-recognizing σ factor.
Andrew Cheng +7 more
doaj +1 more source
Chlamydial disease pathogenesis. The 57-kD chlamydial hypersensitivity antigen is a stress response protein. [PDF]
The Journal of experimental medicine, 1989 Chlamydia trachomatis infection of humans is commonly a localized inflammation that can result in infertility, blindness, and perhaps arthritis. The pathogenic process(es) that cause these sequelae are thought to be immunological. A 57-kD protein that is common among Chlamydia elicits ocular inflammation when introduced onto the conjunctivae of guinea ...
R P, Morrison +3 more
openaire +2 more sources
Damage/Danger Associated Molecular Patterns (DAMPs) Modulate Chlamydia pecorum and C. trachomatis Serovar E Inclusion Development In Vitro. [PDF]
PLoS ONE, 2015 Persistence, more recently termed the chlamydial stress response, is a viable but non-infectious state constituting a divergence from the characteristic chlamydial biphasic developmental cycle.
Cory Ann Leonard +2 more
doaj +1 more source
Identification of a GrgA-Euo-HrcA Transcriptional Regulatory Network in Chlamydia
mSystems, 2021 Chlamydia trachomatis is an obligate intracellular bacterium whose unique developmental cycle consists of an infectious elementary body and a replicative reticulate body.
Wurihan Wurihan +10 more
doaj +1 more source