Results 41 to 50 of about 5,109 (221)

Analysis of polymorphic membrane protein expression in cultured cells Identifies PmpA and PmpH of Chlamydia psittaci as candidate factors in pathogenesis and immunity to infection [PDF]

, 2016
The polymorphic membrane protein (Pmp) paralogous families of Chlamydia trachomatis, Chlamydia pneumoniae and Chlamydia abortus are putative targets for Chlamydia vaccine development. To determine whether this is also the case for Pmp family members of C.
Bavoil, Patrik, Creasy, Heather Huot, De Vos, Winnok, Hsia, Ru-ching, Marques, Patricia X, Ravel, Jacques, Van Lent, Sarah, Vanrompay, Daisy   +7 more
core   +2 more sources

New insights into a persistent problem — chlamydial infections [PDF]

Journal of Clinical Investigation, 2003
Tissue tropism of clinical ocular and genital Chlamydia trachomatis strains is shown to be linked to the tryptophan synthase genotype. It is suggested that, in the presence of IFN-gamma, which depletes available tryptophan, there exist unique host-parasite interactions that may contribute to persistent chlamydial infection.
openaire   +2 more sources

Chlamydial infection of the gastrointestinal tract: a reservoir for persistent infection [PDF]

Pathogens and Disease, 2013
The mechanism by which chlamydiae persist in vivo remains undefined; however, chlamydiae in most animals persist in the gastrointestinal tract (GI) and are transmitted via the fecal-oral route. Oral infection of mice with Chlamydia muridarum was previously shown to establish a long-term persistent infection in the GI tract. In this study, BALB/c, DBA/2,
Laxmi, Yeruva, Nicole, Spencer, Anne K, Bowlin, Yin, Wang, Roger G, Rank   +4 more
openaire   +2 more sources

TLR3 Deficiency Leads to a Dysregulation in the Global Gene-Expression Profile in Murine Oviduct Epithelial Cells Infected with Chlamydia muridarum [PDF]

, 2019
OBJECTIVE Describe the implementation and effects of Mobile Acute Care for Elders (MACE) consultation at a Veterans Affairs Medical Center (VAMC). DESIGN Retrospective cohort analysis.
Derbigny, Wilbert A, Kumar, Ramesh
core   +2 more sources

Akt Phosphorylation Influences Persistent Chlamydial Infection and Chlamydia-Induced Golgi Fragmentation Without Involving Rab14 [PDF]

Frontiers in Cellular and Infection Microbiology, 2021
Chlamydia trachomatis is an obligate intracellular bacterium that causes multiple diseases involving the eyes, gastrointestinal tract, and genitourinary system. Previous studies have identified that in acute chlamydial infection, C. trachomatis requires Akt pathway phosphorylation and Rab14-positive vesicles to transmit essential lipids from the Golgi ...
Xiaobao Huang, Jinfeng Tan, Xiaohong Chen, Mingna Liu, Huiling Zhu, Wenjing Li, Zhenjian He, Jiande Han, Chunguang Ma   +8 more
openaire   +3 more sources

Fosmidomycin, an inhibitor of isoprenoid synthesis, induces persistence in Chlamydia by inhibiting peptidoglycan assembly.

PLoS Pathogens, 2019
The antibiotic, fosmidomycin (FSM) targets the methylerythritol phosphate (MEP) pathway of isoprenoid synthesis by inhibiting the essential enzyme, 1-deoxy-D-xylulose 5-phosphate reductoisomerase (Dxr) and is lethal to intracellular parasites and ...
Jessica A Slade, Mary Brockett, Raghuveer Singh, George W Liechti, Anthony T Maurelli   +4 more
doaj   +1 more source

Host nectin-1 is required for efficient Chlamydia trachomatis serovar E development.

Frontiers in Cellular and Infection Microbiology, 2014
Interaction of Herpes Simplex Virus (HSV) glycoprotein D (gD) with the host cell surface during Chlamydia trachomatis/HSV co-infection stimulates chlamydiae to become persistent.
Jennifer Vanover Hall, Jennifer Vanover Hall, Jingru eSun, Jessica eSlade, Jessica eSlade, Jennifer eKintner, Marissa eBambino, Judy eWhittimore, Robert V. Schoborg, Robert V. Schoborg   +9 more
doaj   +1 more source

Pathogen burden, inflammation, proliferation and apoptosis in human in-stent restenosis - Tissue characteristics compared to primary atherosclerosis [PDF]

, 2004
Pathogenic events leading to in-stent restenosis (ISR) are still incompletely understood. Among others, inflammation, immune reactions, deregulated cell death and growth have been suggested. Therefore, atherectomy probes from 21 patients with symptomatic
Abdelmegui AE, Alexander Jabs, Bauriedel G, Bauriedel G, Berndt Lüderitz, Carter AJ, Chiu B, Dirk Skowasch, Epstein SE, Farb A, Gerhard Bauriedel, Kearney M, Kol A, Komatsu R, Mayr M, Moreno PR, Neumann FJ, Nicolas Wernert, O'Brien ER, Pickering JG, René Andrié, Sabine Dinkelbach, Simonton CA, Thomas M. Schiele, Zohlnhofer D   +24 more
core   +1 more source

Penicillin induced persistence in Chlamydia trachomatis: high quality time lapse video analysis of the developmental cycle. [PDF]

PLoS ONE, 2009
BACKGROUND:Chlamydia trachomatis is a major human pathogen with a unique obligate intracellular developmental cycle that takes place inside a modified cytoplasmic structure known as an inclusion.
Rachel J Skilton, Lesley T Cutcliffen, David Barlow, Yibing Wang, Omar Salim, Paul R Lambden, Ian N Clarke   +6 more
doaj   +1 more source

c-Myc plays a key role in IFN-γ-induced persistence of Chlamydia trachomatis

eLife, 2022
Chlamydia trachomatis (Ctr) can persist over extended times within their host cell and thereby establish chronic infections. One of the major inducers of chlamydial persistence is interferon-gamma (IFN-γ) released by immune cells as a mechanism of immune
Nadine Vollmuth, Lisa Schlicker, Yongxia Guo, Pargev Hovhannisyan, Sudha Janaki-Raman, Naziia Kurmasheva, Werner Schmitz, Almut Schulze, Kathrin Stelzner, Karthika Rajeeve, Thomas Rudel   +10 more
doaj   +1 more source