Results 21 to 30 of about 23,600 (247)

Acalabrutinib with or without obinutuzumab versus chlorambucil and obinutuzmab for treatment-naive chronic lymphocytic leukaemia (ELEVATE TN): a randomised, controlled, phase 3 trial.

The Lancet, 2020
BACKGROUND Acalabrutinib is a selective, covalent Bruton tyrosine-kinase inhibitor with activity in chronic lymphocytic leukaemia. We compare the efficacy of acalabrutinib with or without obinutuzumab against chlorambucil with obinutuzumab in patients ...
J. Sharman, M. Egyed, W. Jurczak, A. Skarbnik, J. Pagel, I. Flinn, M. Kamdar, T. Munir, R. Walewska, G. Corbett, L. Fogliatto, Y. Herishanu, V. Banerji, S. Coutre, G. Follows, P. Walker, K. Karlsson, P. Ghia, A. Janssens, F. Cymbalista, J. Woyach, G. Salles, W. Wierda, R. Izumi, V. Munugalavadla, P. Patel, M. Wang, S. Wong, J. Byrd   +28 more
semanticscholar   +1 more source

Polymorphism in glutathione S-transferase P1 is associated with susceptibility to chemotherapyinduced leukemia [PDF]

, 2001
Glutathione S-transferases (GSTs) detoxify potentially mutagenic and toxic DNA-reactive electrophiles, including metabolites of several chemotherapeutic agents, some of which are suspected human carcinogens.
Allan, J.M., Wild, C.P., Rollinson, S., Willett, E.V., Moorman, A.V., Dovey, G.J., Roddam, P.L., Roman, E., Cartwright, R.A., Morgan, G.J.   +9 more
core   +7 more sources

Physicochemical Study of Albumin Nanoparticles with Chlorambucil

Processes, 2022
Currently, nanotechnology is considered a promising strategy to enhance drug solubility and other physicochemical properties. Albumin is a biopolymer that can be used in drug delivery systems due to its biodegradability and biocompatibility.
K. Kulig, M. Ziąbka, K. Pilarczyk, A. Owczarzy, W. Rogóż, M. Maciążek-Jurczyk   +5 more
semanticscholar   +1 more source

Chlorambucil-Loaded Graphene-Oxide-Based Nano-Vesicles for Cancer Therapy

Pharmaceutics, 2023
In this study, the authors have designed biocompatible nano-vesicles using graphene oxide (GO) for the release of chlorambucil (CHL) drugs targeting cancerous cells.
Surabhi Kumari, Anuj Nehra, Kshitij Gupta, Anu Puri, Vinay Kumar, Krishna Pal Singh, Mukesh Kumar, Ashutosh Sharma   +7 more
doaj   +1 more source

Potent Chlorambucil-Platinum(IV) Prodrugs

International Journal of Molecular Sciences, 2022
The DNA-alkylating derivative chlorambucil was coordinated in the axial position to atypical cytotoxic, heterocyclic, and non-DNA coordinating platinum(IV) complexes of type, [PtIV(HL)(AL)(OH)2](NO3)2 (where HL is 1,10-phenanthroline, 5-methyl-1,10 ...
Angelico D Aputen, M. Elias, J. Gilbert, J. Sakoff, C. Gordon, K. Scott, J. Aldrich-Wright   +6 more
semanticscholar   +1 more source

Nasal Lymphoma with Low Mitotic Index in Three Cats Treated with Chlorambucil and Prednisolone

Veterinary Sciences, 2022
Lymphoma is the most common tumor of the nasal cavity in cats. Commonly used treatment modalities are radiotherapy and chemotherapy, or both. Typical chemotherapy protocols used in cats with nasal lymphoma are COP (cyclophosphamide, vincristine ...
Karen W. L. Ng, Julia A. Beatty, May P. Y. Tse, Antonio Giuliano   +3 more
doaj   +1 more source

Successful outcome after a single endoscopic fecal microbiota transplantation in a Shiba dog with non-responsive enteropathy during the treatment with chlorambucil

Journal of Veterinary Medical Science, 2021
A 7-year 6-month-old, castrated male Shiba dog presented with a 1-month history of lethargy, anorexia, vomiting, and frequent watery diarrhea. Weight loss, hypoalbuminemia, anemia, and leukocytosis were detected at the first visit.
Koji Sugita, A. Shima, Kaho Takahashi, Yasuyoshi Matsuda, Masaki Miyajima, Marin Hirokawa, H. Kondo, J. Kimura, Genki Ishihara, K. Ohmori   +9 more
semanticscholar   +1 more source

Cytotoxicity of chlorambucil immobilized on magnetic iron oxide nanoparticles Fe3O4

Micro & Nano Letters, 2021
Chlorambucil is a nitrogen mustard alkylating agent used for the treatment of various malignant and non‐malignant cancers. The use of the chemotherapeutic is limited by its toxic side effects which precludes the use of optimal doses.
Julia Nowak‐Jary, Beata Machnicka, Jacek Juliusz Kozioł   +2 more
doaj   +1 more source

Case Report: Long-Term Survival of a Dog With Chronic Lymphocytic Leukemia Treated With Chlorambucil, Prednisolone, and Imatinib

Frontiers in Veterinary Science, 2022
A 7-year-old castrated male Poodle dog presented with chronic progressive lymphocytosis. Hematologic and peripheral blood smear findings included remarkable lymphocytosis with well-differentiated small lymphocytes. Cytology of bone marrow aspirate showed
Ga-Won Lee, Min-Hee Kang, Jin-Ha Jeon, Doo-Won Song, Woong-Bin Ro, Heyong-Seok Kim, Hee-Myung Park   +6 more
doaj   +1 more source

Long-term efficacy and safety of first-line ibrutinib treatment for patients with CLL/SLL: 5 years of follow-up from the phase 3 RESONATE-2 study. [PDF]

, 2019
RESONATE-2 is a phase 3 study of first-line ibrutinib versus chlorambucil in chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL). Patients aged ≥65 years (n = 269) were randomized 1:1 to once-daily ibrutinib 420 mg continuously or ...
Bairey, Osnat, Barr, Paul M., Burger, Jan A., Coutre, Steven E., Dai, Sandra, Dean, James P., Devereux, Stephen, Ghia, P, Grosicki, Sebastian, Hillmen, Peter, Kipps, Thomas J., Lal, Indu, McCarthy, Helen, Moreno, Carol, Offner, Fritz, Owen, Carolyn, Robak, Tadeusz, Simpson, David, Tedeschi, Alessandra, Universitat Autònoma de Barcelona   +19 more
core   +3 more sources