Results 21 to 30 of about 24,793 (292)

Transcriptomic profiles and 5-year results from the randomized CLL14 study of venetoclax plus obinutuzumab versus chlorambucil plus obinutuzumab in chronic lymphocytic leukemia

Nature Communications, 2023
Data on long-term outcomes and biological drivers associated with depth of remission after BCL2 inhibition by venetoclax in the treatment of chronic lymphocytic leukemia (CLL) are limited.
O. Al-Sawaf, Can Zhang, H. Jin, S. Robrecht, Yoonha Choi, Sandhya Balasubramanian, A. Kotak, Y. Chang, A. Fink, E. Tausch, C. Schneider, M. Ritgen, K. Kreuzer, B. Chyla, Joe Paulson, C. Pallasch, L. Frenzel, M. Peifer, B. Eichhorst, S. Stilgenbauer, Yanwen Jiang, M. Hallek, K. Fischer   +22 more
semanticscholar   +1 more source

Efficacy and safety in a 4-year follow-up of the ELEVATE-TN study comparing acalabrutinib with or without obinutuzumab versus obinutuzumab plus chlorambucil in treatment-naïve chronic lymphocytic leukemia

Leukemia, 2022
Efficacy and safety in a 4-year follow-up of the ELEVATE-TN study comparing acalabrutinib with or without obinutuzumab versus obinutuzumab plus chlorambucil in treatment-naïve chronic lymphocytic leukemia Jeff P. Sharman 1, Miklos Egyed, Wojciech Jurczak
J. Sharman, M. Egyed, W. Jurczak, A. Skarbnik, J. Pagel, I. Flinn, M. Kamdar, T. Munir, R. Walewska, G. Corbett, L. Fogliatto, Y. Herishanu, V. Banerji, S. Coutre, G. Follows, P. Walker, K. Karlsson, P. Ghia, A. Janssens, F. Cymbalista, J. Woyach, E. Ferrant, W. Wierda, V. Munugalavadla, T. Yu, M. Wang, J. Byrd   +26 more
semanticscholar   +1 more source

Impact of Minimal Residual Disease on Progression-Free Survival Outcomes After Fixed-Duration Ibrutinib-Venetoclax Versus Chlorambucil-Obinutuzumab in the GLOW Study

Journal of Clinical Oncology, 2023
PURPOSE In GLOW, fixed-duration ibrutinib + venetoclax showed superior progression-free survival (PFS) versus chlorambucil + obinutuzumab in older/comorbid patients with previously untreated chronic lymphocytic leukemia (CLL).
T. Munir, C. Moreno, C. Owen, G. Follows, O. Benjamini, A. Janssens, M. Levin, A. Osterborg, T. Robak, M. Šimkovič, D. Stevens, S. Voloshin, V. Vorobyev, M. Yağcı, L. Ysebaert, K. Qi, Qianya Qi, Lori Parisi, Srimathi Srinivasan, N. Schuier, K. Baeten, A. Howes, D. B. Caces, C. Niemann, A. Kater   +24 more
semanticscholar   +1 more source

In vitro effect of chlorambucil on human glioma cell lines (SF767 and U87-MG), and human microvascular endothelial cell (HMVEC) and endothelial progenitor cells (ECFCs), in the context of plasma chlorambucil concentrations in tumor-bearing dogs. [PDF]

PLoS ONE, 2018
The objective of this study was to investigate a possible mechanism of action of metronomic chlorambucil on glioma by studying the in vitro cytotoxicity and anti-angiogenic effects on glioma and endothelial cells, respectively. The in vitro LD50 and IC50
Michael J Reese, Deborah W Knapp, Kimberly M Anderson, Julie A Mund, Jamie Case, David R Jones, Rebecca A Packer   +6 more
doaj   +1 more source

Economic evaluation of obinutuzumab in combination with chlorambucil in first-line treatment of patients with chronic lymphocytic leukemia in Spain [PDF]

ClinicoEconomics and Outcomes Research, 2016
Luis Felipe Casado,1 Amparo Burgos,2 Eva González-Haba,3 Javier Loscertales,4 Tania Krivasi,5 Javier Orofino,6 Carlos Rubio-Terres,7 Darío Rubio-Rodríguez7 1Hematology Department, Hospital Virgen de la Salud, Toledo, Spain; 2Pharmacy
Casado LF, Burgos A, González-Haba E, Loscertales J, Krivasi T, Orofino J, Rubio-Terres C, Rubio-Rodríguez D   +7 more
doaj   +1 more source

Potent Chlorambucil-Platinum(IV) Prodrugs

International Journal of Molecular Sciences, 2022
The DNA-alkylating derivative chlorambucil was coordinated in the axial position to atypical cytotoxic, heterocyclic, and non-DNA coordinating platinum(IV) complexes of type, [PtIV(HL)(AL)(OH)2](NO3)2 (where HL is 1,10-phenanthroline, 5-methyl-1,10 ...
Angelico D Aputen, M. Elias, J. Gilbert, J. Sakoff, C. Gordon, K. Scott, J. Aldrich-Wright   +6 more
semanticscholar   +1 more source

Physicochemical Study of Albumin Nanoparticles with Chlorambucil

Processes, 2022
Currently, nanotechnology is considered a promising strategy to enhance drug solubility and other physicochemical properties. Albumin is a biopolymer that can be used in drug delivery systems due to its biodegradability and biocompatibility.
K. Kulig, M. Ziąbka, K. Pilarczyk, A. Owczarzy, W. Rogóż, M. Maciążek-Jurczyk   +5 more
semanticscholar   +1 more source

Long-term management of a cat with nasopharyngeal lymphoma by chlorambucil [PDF]

Open Veterinary Journal, 2021
Background: Lymphoma in the nasal cavity is the most common tumor of cats' upper respiratory tract. However, the effect of single-agent chlorambucil on nasal or nasopharyngeal lymphoma has not been evaluated in cats.
Kaho Takahashi, Takashi Baba, Marin Hirokawa, Masaki Miyajima, Miori Kishimoto, Junpei Kimura, Hirotaka Kondo, Keitaro Ohmori   +7 more
doaj   +1 more source

Nasal Lymphoma with Low Mitotic Index in Three Cats Treated with Chlorambucil and Prednisolone

Veterinary Sciences, 2022
Lymphoma is the most common tumor of the nasal cavity in cats. Commonly used treatment modalities are radiotherapy and chemotherapy, or both. Typical chemotherapy protocols used in cats with nasal lymphoma are COP (cyclophosphamide, vincristine ...
Karen W. L. Ng, Julia A. Beatty, May P. Y. Tse, Antonio Giuliano   +3 more
doaj   +1 more source

Chlorambucil-Loaded Graphene-Oxide-Based Nano-Vesicles for Cancer Therapy

Pharmaceutics, 2023
In this study, the authors have designed biocompatible nano-vesicles using graphene oxide (GO) for the release of chlorambucil (CHL) drugs targeting cancerous cells.
Surabhi Kumari, Anuj Nehra, Kshitij Gupta, Anu Puri, Vinay Kumar, Krishna Pal Singh, Mukesh Kumar, Ashutosh Sharma   +7 more
doaj   +1 more source