Results 31 to 40 of about 10,072 (202)

Chlorambucil effect on B lymphocites in the peripheral blood of patients with chronic lymphocytic leukemia: Cell ultrastructure investigation [PDF]

Vojnosanitetski Pregled, 2003
B type Chronic Lymphocytic Leukemia (B-CLL) is a malignant disease characterized by the progressive accumulation of morphologically mature, but immunologically dysphunctional CD 5+ lymphocytes in the blood, bone marrow and lymphatic organs in the early ...
Brajušković Goran R., Marjanović Slobodan A., Škaro-Milić Anđelija B.   +2 more
doaj   +1 more source

Antibody as carrier of chlorambucil [PDF]

Cancer, 1972
A surface-localizing heterologous antibody against the mouse Ehrlich ascites carcinoma could be bound to chlorambucil without causing the loss of alkylating activity of chlorambucil or interfering with the reactivity of the antibody with tumor cells. Chlorambucil, when bound to the antibody, was a much more effective tumor inhibitor, both in vitro and ...
M. R. C. Path, S. P. Nigam, T. Ghose
openaire   +3 more sources

Single Enema Fecal Microbiota Transplantation in Cats With Chronic Enteropathy. [PDF]

J Vet Intern Med
ABSTRACT Background Chronic enteropathies (CE) are common in cats, and alterations of the intestinal microbiota might be involved in the pathogenesis. Hypothesis/Objectives To evaluate the efficacy of a single enema fecal microbiota transplantation (FMT) in improving intestinal dysbiosis and clinical scores in cats with CE.
Karra DA, Suchodolski JS, Newman SJ, Flouraki E, Lidbury JA, Steiner JM, Xenoulis PG.   +6 more
europepmc   +2 more sources

Chlorambucil vs. combined chlorambucil-corticosteroid therapy in chronic lymphocytic leukemia [PDF]

Cancer, 1973
Eleven patients with chronic lymphocytic leukemia were treated with chlorambucil alone and 15 patients received combined chlorambucil-prednisone therapy in a double-blind study. Mean age, duration of disease, physical findings, and hematologic data in the two groups were essentially comparable. Complete remission was observed in 3 and partial remission
Dinesh V. Desai, Tin Han, Ediz Z. Ezdinli, Katsutaro Shimaoka   +3 more
openaire   +3 more sources

Chlorambucil combination therapy in refractory serpiginous choroiditis: A cure?

American Journal of Ophthalmology Case Reports, 2021
Purpose: To find a remedy for serpiginous choroiditis refractory to oral prednisone and chlorambucil treatment. Observations: Eight eyes of four patients (all female) with advanced macular involvement secondary to serpiginous choroiditis were included in
Arash Maleki, Anapatricia Maldonado Cerda, Cristina M. Garcia, Mike Zein, Ambika Manhapra, C. Stephen Foster   +5 more
doaj  

Kolaviron and L-Ascorbic Acid Attenuate Chlorambucil-Induced Testicular Oxidative Stress in Rats

Journal of Toxicology, 2014
Chlorambucil (4-[4-[bis(2-chloroethyl)amino]phenyl]butanoic acid) is an alkylating agent, indicated in chronic lymphocytic leukaemia. Kolaviron (KV), a biflavonoid complex from Garcinia kola, and L-ascorbic acid (AA) are known to protect against ...
Ebenezer Tunde Olayinka, Ayokanmi Ore
doaj   +1 more source

Paraneoplastic pemphigus - a rare autoimmune complication in patients with chronic lymphocytic leukemia

Онкогематология, 2022
This is a case report of the 64-year-old male patient who suffered of previously untreated chronic lymphocytic leukemia (CLL), and paraneoplastic pemphigus. He was treated with prednisolone, MabThera, chlorambucil and cyclophosphamide.
M. A. Volkova, M. Yu. Kitchigina, N. S. Potekaev, N. P. Teplyuk, A. G. Kupriyanova   +4 more
doaj   +1 more source

Azathioprine, cyclophosphamide and chlorambucil

Baillière's Clinical Rheumatology, 1990
Immunosuppressive agents serve a major role in the management of once-fatal conditions such as the systemic necrotizing vasculitides, but they are also being used in more common, chronic inflammatory disorders such as rheumatoid arthritis. The drugs are all capable of reducing cell division but they differ in their modes of action.
Luqmani, R, Palmer, R, Bacon, P
openaire   +3 more sources

Chlorambucil-Induced Acute Interstitial Pneumonitis

Case Reports in Hematology, 2014
Chlorambucil is an alkylating agent commonly used in treatment of chronic lymphocytic leukemia (CLL). We report a case of interstitial pneumonitis developing in an 83-year-old man 1.5 months after completing a six-month course of chlorambucil for CLL ...
Hammad Shafqat, Adam J. Olszewski
doaj   +1 more source

First-line treatment of chronic lymphocytic leukemia with ibrutinib plus obinutuzumab versus chlorambucil plus obinutuzumab: final analysis of the randomized, phase III iLLUMINATE trial

Haematologica, 2022
iLLUMINATE is a randomized, open-label phase III study of ibrutinib plus obinutuzumab (n=113) versus chlorambucil plus obinutuzumab (n=116) as first-line therapy for patients with chronic lymphocytic leukemia or small lymphocytic lymphoma.
Carol Moreno, Richard Greil, Fatih Demirkan, Alessandra Tedeschi, Bertrand Anz, Loree Larratt, Martin Simkovic, Jan Novak, Vladimir Strugov, Devinder Gill, John G. Gribben, Kevin Kwei, Sandra Dai, Emily Hsu, James P. Dean, Ian W. Flinn   +15 more
doaj   +1 more source