Results 51 to 60 of about 24,793 (292)

Kolaviron and L-Ascorbic Acid Attenuate Chlorambucil-Induced Testicular Oxidative Stress in Rats

Journal of Toxicology, 2014
Chlorambucil (4-[4-[bis(2-chloroethyl)amino]phenyl]butanoic acid) is an alkylating agent, indicated in chronic lymphocytic leukaemia. Kolaviron (KV), a biflavonoid complex from Garcinia kola, and L-ascorbic acid (AA) are known to protect against ...
Ebenezer Tunde Olayinka, Ayokanmi Ore
doaj   +1 more source

Possible Subclinical Leaflet Thrombosis in Bioprosthetic Aortic Valves [PDF]

, 2016
To the Editor: Makkar et al. (Nov. 19 issue)(1) report possible subclinical leaflet thrombosis in up to 40% of patients involved in a clinical trial of transcatheter aortic-valve replacement (TAVR).
Burriesci, Gaetano, Colli, Andrea, Ducci, Andrea   +2 more
core   +2 more sources

Characterizing and prognosticating chronic lymphocytic leukemia in the elderly: prospective evaluation on 455 patients treated in the United States. [PDF]

, 2017
BACKGROUND: Median age at diagnosis of patients with chronic lymphocytic leukemia (CLL) is \u3e 70 years. However, the majority of clinical trials do not reflect the demographics of CLL patients treated in the community.
Bhushan, Shriya, Davids, Matthew S., Flick, E. Dawn, Flowers, Christopher R., Grinblatt, David L., Kiselev, Pavel, Lamanna, Nicole, Mato, Anthony, Nabhan, Chadi, Sharman, Jeff P., Sullivan, Kristen, Swern, Arlene S., Weiss, Mark A.   +12 more
core   +3 more sources

Chlorambucil-Induced Acute Interstitial Pneumonitis

Case Reports in Hematology, 2014
Chlorambucil is an alkylating agent commonly used in treatment of chronic lymphocytic leukemia (CLL). We report a case of interstitial pneumonitis developing in an 83-year-old man 1.5 months after completing a six-month course of chlorambucil for CLL ...
Hammad Shafqat, Adam J. Olszewski
doaj   +1 more source

The DiSC assay - A cost-effective guide to treatment for chronic lymphocytic leukemia? [PDF]

, 1999
The differential staining cytotoxicity (DISC) assay involves in vitro drug panel testing against patient tumor cells to identify optimal therapy. This observational study investigated whether DISC assay guided treatment could improve outcome in patients ...
Bosanquet, A.G., Drummond, M.F., Mason, J.M., Sheldon, T.A.   +3 more
core   +1 more source

Final Results of the IELSG-19 Randomized Trial of Mucosa-Associated Lymphoid Tissue Lymphoma: Improved Event-Free and Progression-Free Survival With Rituximab Plus Chlorambucil Versus Either Chlorambucil or Rituximab Monotherapy.

Journal of Clinical Oncology, 2017
Purpose There is no consensus on the optimal systemic treatment of patients with extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue.
E. Zucca, A. Conconi, G. Martinelli, R. Bouabdallah, A. Tucci, U. Vitolo, M. Martelli, R. Pettengell, G. Salles, C. Sebban, A. Guillermo, G. Pinotti, L. Devizzi, F. Morschhauser, H. Tilly, V. Torri, S. Hohaus, A. Ferreri, P. Zachée, A. Bosly, C. Haioun, C. Stelitano, M. Bellei, M. Ponzoni, A. Moreau, A. Jack, E. Campo, L. Mazzucchelli, F. Cavalli, P. Johnson, C. Thieblemont   +30 more
semanticscholar   +1 more source

Benzotriazine Di-Oxide Prodrugs for Exploiting Hypoxia and Low Extracellular pH in Tumors

Molecules, 2019
Extracellular acidification is an important feature of tumor microenvironments but has yet to be successfully exploited in cancer therapy. The reversal of the pH gradient across the plasma membrane in cells that regulate intracellular pH (pHi) has ...
Michael P. Hay, Hong Nam Shin, Way Wua Wong, Wan Wan Sahimi, Aaron T.D. Vaz, Pooja Yadav, Robert F. Anderson, Kevin O. Hicks, William R. Wilson   +8 more
doaj   +1 more source

A five‐year follow‐up of untreated patients with chronic lymphocytic leukaemia treated with ofatumumab and chlorambucil: final analysis of the Complement 1 phase 3 trial

British Journal of Haematology, 2020
The Complement 1 trial investigated the efficacy and safety of ofatumumab + chlorambucil with chlorambucil monotherapy in patients with previously untreated chronic lymphocytic leukaemia (CLL). On long‐term follow‐up in the chemoimmunotherapy arm vs. the
F. Offner, T. Robak, A. Janssens, K. Govind Babu, J. Kłoczko, S. Grosicki, J. Mayer, P. Panagiotidis, A. Schuh, A. Pettitt, M. Montillo, Olena Werner, Ghislaine Vincent, Sadhvi Khanna, P. Hillmen   +14 more
semanticscholar   +1 more source

Recent progress in mitochondria-targeted drug and drug-free agents for cancer therapy [PDF]

, 2019
The mitochondrion is a dynamic eukaryotic organelle that controls lethal and vital functions of the cell. Being a critical center of metabolic activities and involved in many diseases, mitochondria have been attracting attention as a potential target for
Jeena, M.T., Jin, Seongeon, Kim, Sangpil, Ryu, Ja-Hyoung   +3 more
core   +1 more source

Successful rescue treatment using chlorambucil for presumed recurrence of sinonasal lymphoma in a cat

Journal of Feline Medicine and Surgery Open Reports, 2023
Case summary A 12-year-old male neutered domestic shorthair cat presented with a 2-week history of serous unilateral nasal discharge, swelling of the nasal bridge and sneezing.
Sho Goto, Fumikazu Muto, Ryota Iwasaki, Takashi Mori   +3 more
doaj   +1 more source