Results 51 to 60 of about 10,072 (202)

New potential therapeutic approach for the treatment of B-Cell malignancies using chlorambucil/hydroxychloroquine-loaded anti-CD20 nanoparticles. [PDF]

PLoS ONE, 2013
Current B-cell disorder treatments take advantage of dose-intensive chemotherapy regimens and immunotherapy via use of monoclonal antibodies. Unfortunately, they may lead to insufficient tumor distribution of therapeutic agents, and often cause adverse ...
Nelly Mezzaroba, Sonia Zorzet, Erika Secco, Stefania Biffi, Claudio Tripodo, Marco Calvaruso, Ramiro Mendoza-Maldonado, Sara Capolla, Marilena Granzotto, Ruben Spretz, Gustavo Larsen, Sandra Noriega, Marianna Lucafò, Eduardo Mansilla, Chiara Garrovo, Gustavo H Marín, Gabriele Baj, Valter Gattei, Gabriele Pozzato, Luis Núñez, Paolo Macor   +20 more
doaj   +1 more source

Chlorambucil-Iron Oxide Nanoparticles as a Drug Delivery System for Leukemia Cancer Cells

International Journal of Nanomedicine, 2021
Samer Hasan Hussein-Al-Ali,1,2 Mohd Zobir Hussein,3 Saifullah Bullo,3 Palanisamy Arulselvan4 1Faculty of Pharmacy, Isra University, Amman, 11622, Jordan; 2Department of Chemistry, Faculty of Science, Isra University, Amman, 11622, Jordan; 3Materials ...
Hussein-Al-Ali SH, Hussein MZ, Bullo S, Arulselvan P   +3 more
doaj  

Primary identification of compounds targeting hepatitis B virus capsid formation from the FDA approved drugs

Di-san junyi daxue xuebao, 2019
Objective To identify the candidates targeting capsid formation of HBV by screening a FDA approved drug library. Methods SRluc-HBc6 cells, which indicates the formation of HBc dimers by the split luciferase complementation (SLC), were used as the 1st ...
YUAN Yi, LI Zhiying, WEI Xiafe, SHEN Jing, HU Jieli   +4 more
doaj   +1 more source

The Quinoline Photoremovable Group (PPG) Platform—A Medicinal Chemist's Approach for Photocage Development and Applications

Medicinal Research Reviews, EarlyView.
ABSTRACT Photoremovable protecting groups (PPGs) offer a straightforward solution for the temporary inactivation of biologically active substrates and their subsequent controlled release by light irradiation. Their relatively easy design and mode of application have made them useful tools for studying dynamic biological processes in vitro and in vivo ...
Bence Kontra, Zoltán Mucsi, Janez Ilaš, Petra Dunkel   +3 more
wiley   +1 more source

Long‐term survival in a dog with suspected primary nodal plasmacytoma treated with surgical excision

Veterinary Record Case Reports, EarlyView.
Abstract An 8‐year‐old Staffordshire bull terrier presented for left submandibular lymphadenopathy. Cytology showed a monomorphic population of mature plasma cells suggestive of plasma cell neoplasia. On physical examination, no other lymphadenomegaly, cutaneous or oral lesions were found.
Celia Figueroa‐González, Jérémy Béguin, Rachel Garty, Alexandra Guillén, Sarah Stewart   +4 more
wiley   +1 more source

Chlorambucil Conjugated Ugi Dendrimers with PAMAM-NH₂ Core and Evaluation of Their Anticancer Activity

Pharmaceutics, 2019
Herein, a new Ugi multicomponent reaction strategy is described to enhance activity and solubility of the chemotherapeutic drug chlorambucil through its conjugation to poly(amidoamine) (PAMAM-NH2) dendrimers with the simultaneous introduction of lipidic (
Nalin Seixas, Bruno B. Ravanello, Ibrahim Morgan, Goran N. Kaluđerović, Ludger A. Wessjohann   +4 more
doaj   +1 more source

Impact of Age on Biology, Presentation and Outcomes in Marginal Zone Lymphoma: Results From a Multicenter Cohort Study

Hematological Oncology, Volume 43, Issue 3, May 2025.
ABSTRACT Given the paucity of age‐specific data about biology, presentation, and treatment outcomes in adults with MZL, we sought to evaluate differences between younger (≤ 70 years) and older (> 70 years) patients with MZL in a large retrospective cohort treated in the contemporary era (2010 onwards).
Pallawi Torka, Natalie S. Grover, Timothy J. Voorhees, Reem Karmali, Kaitlin Annunzio, Marcus P. Watkins, Andrea Anampa‐Guzmán, Heather Reves, Montreh Tavakkoli, Beth Christian, Colin Thomas, Stefan K. Barta, Praveen Ramakrishnan Geethakumari, Nancy L. Bartlett, Geoffrey Shouse, Adam J. Olszewski, Narendranath Epperla   +16 more
wiley   +1 more source

Comparison of the Lonidamine Potentiated Effect of Nitrogen Mustard Alkylating Agents on the Systemic Treatment of DB-1 Human Melanoma Xenografts in Mice. [PDF]

PLoS ONE, 2016
Previous NMR studies demonstrated that lonidamine (LND) selectively diminishes the intracellular pH (pHi) of DB-1 melanoma and mouse xenografts of a variety of other prevalent human cancers while decreasing their bioenergetic status (tumor βNTP/Pi ratio)
Kavindra Nath, David S Nelson, Mary E Putt, Dennis B Leeper, Bradley Garman, Katherine L Nathanson, Jerry D Glickson   +6 more
doaj   +1 more source

Obinutuzumab treatment in the elderly patient with chronic lymphocytic leukemia

Clinical Interventions in Aging, 2015
Karen Seiter, Aleksandra Mamorska-DygaDepartment of Medicine, Division of Hematology/Oncology, New York Medical College, Valhalla, NY, USA Abstract: Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults in Western countries ...
Seiter K, Mamorska-Dyga A
doaj  

Cancer Accumulation and Anticancer Activity of “CROX (Cluster Regulation of RUNX)” PIP in HER2‐Positive Gastric Cancer Evaluated by Chicken Egg Cancer Model

Cancer Medicine, Volume 14, Issue 7, April 2025.
Cancer accumulation and anticancer activity of “CROX (cluster regulation of RUNX)” PIP in HER2‐positive gastric cancer evaluated by chicken egg cancer model. ABSTRACT Background We have focused on pyrrole‐imidazole (PI) polyamide compounds, which preferentially bind to their target DNA sequences.
Tatsuya Masuda, Takayoshi Watanabe, Yasutoshi Tatsumi, Jason Lin, Kazuhiro Okumura, Toshinori Ozaki, Hiroshi Sugiyama, Yasuhiko Kamikubo   +7 more
wiley   +1 more source