Results 61 to 70 of about 19,748 (246)
Hybrid inhibitors of DNA and HDACs remarkably enhance cytotoxicity in leukaemia cells
Journal of Enzyme Inhibition and Medicinal Chemistry, 2020 Chlorambucil is a nitrogen mustard-based DNA alkylating drug, which is widely used as a front-line treatment of chronic lymphocytic leukaemia (CLL). Despite its widespread application and success for the initial treatment of leukaemia, a majority of ...
Yoojin Song +4 more
doaj +1 more source
Frontiers in Oncology, 2020 Previous studies investigated the efficacy and the safety of bendamustine (B) vs. chlorambucil (Chl) associated with rituximab (R) in fludarabine-ineligible patients with treated and untreated chronic lymphocytic leukemia (CLL).
Francesco Autore +19 more
doaj +1 more source
Imaging findings and clinical outcome in three cats with possible inflammatory ureteritis
Veterinary Record Case Reports, Volume 14, Issue 1, February 2026.Abstract Three adult cats presented to our institution for evaluation of non‐specific clinical signs and azotaemia. All cats had sonographic evidence of renal pelvic and ureteral dilation, concerning for a ureteral obstruction without a definitive mechanical cause identified. Anti‐inflammatory doses of corticosteroids were administered over an extended
Elisa L. Heacock +3 more
wiley +1 more source
Caspase 8 activation independent of Fas (CD95/APO-1) signaling may mediate killing of B-chronic lymphocytic leukemia cells by cytotoxic drugs or gamma radiation. [PDF]
, 2001 Ligation of the cell-surface Fas molecule by its ligand (Fas-L) or agonistic anti-Fas monoclonal antibodies results in the cleavage and activation of the cysteine protease procaspase 8 followed by the activation of procaspase 3 and by apoptosis.
Folarin, NI +8 more
core
The DiSC assay - A cost-effective guide to treatment for chronic lymphocytic leukemia? [PDF]
, 1999 The differential staining cytotoxicity (DISC) assay involves in vitro drug panel testing against patient tumor cells to identify optimal therapy. This observational study investigated whether DISC assay guided treatment could improve outcome in patients ...
Bosanquet, A.G. +3 more
core +1 more source
European Journal of Haematology, Volume 116, Issue 2, Page 104-115, February 2026.ABSTRACT Background/Objectives Bruton tyrosine kinase inhibitors (BTKis) have revolutionized treatment for chronic lymphocytic leukemia (CLL), but cardiovascular (CV) toxicities pose significant challenges. Second‐generation BTKis offer improved target specificity, yet CV risks persist.
Stefano Oliva, Stefano Molica
wiley +1 more source
New potential therapeutic approach for the treatment of B-Cell malignancies using chlorambucil/hydroxychloroquine-loaded anti-CD20 nanoparticles. [PDF]
PLoS ONE, 2013 Current B-cell disorder treatments take advantage of dose-intensive chemotherapy regimens and immunotherapy via use of monoclonal antibodies. Unfortunately, they may lead to insufficient tumor distribution of therapeutic agents, and often cause adverse ...
Nelly Mezzaroba +20 more
doaj +1 more source
Chlorambucil-Iron Oxide Nanoparticles as a Drug Delivery System for Leukemia Cancer Cells
International Journal of Nanomedicine, 2021 Samer Hasan Hussein-Al-Ali,1,2 Mohd Zobir Hussein,3 Saifullah Bullo,3 Palanisamy Arulselvan4 1Faculty of Pharmacy, Isra University, Amman, 11622, Jordan; 2Department of Chemistry, Faculty of Science, Isra University, Amman, 11622, Jordan; 3Materials ...
Hussein-Al-Ali SH +3 more
doaj
The Interaction of the Chemotherapeutic Drug Chlorambucil with Human Glutathione Transferase A1-1: Kinetic and Structural Analysis [PDF]
, 2013 Glutathione transferases (GSTs) are enzymes that contribute to cellular detoxification by catalysing the nucleophilic attack of glutathione (GSH) on the electrophilic centre of a number of xenobiotic compounds, including several chemotherapeutic drugs ...
Axarli, Irine +7 more
core +3 more sources
Di-san junyi daxue xuebao, 2019 Objective To identify the candidates targeting capsid formation of HBV by screening a FDA approved drug library. Methods SRluc-HBc6 cells, which indicates the formation of HBc dimers by the split luciferase complementation (SLC), were used as the 1st ...
YUAN Yi +4 more
doaj +1 more source