Results 61 to 70 of about 23,600 (247)
Research advances in the applications of mitochondria‐targeted cyanine dyes in imaging
VIEW, EarlyView.Near‐infrared (NIR) fluorescence imaging, a novel non‐invasive diagnostic tool, plays a crucial role in the imaging and monitoring of solid tumors. At its core are NIR fluorescent dyes, which are widely utilized due to their ability to minimize tissue autofluorescence interference, thereby significantly enhancing the signal‐to‐noise ratio (SNR) and ...
Hongye Liao +8 more
wiley +1 more source
Chemical genetics analysis of an aniline mustard anticancer agent reveals complex I of the electron transport chain as a target [PDF]
, 2011 Supplementary information is available at the Journal of Biological Chemistry website.The antitumor agent 11β (CAS 865070-37-7), consisting of a DNA-damaging aniline mustard linked to an androgen receptor (AR) ligand, is known to form covalent DNA ...
Cossarizza +30 more
core +1 more source
Mycosis fungoides and Sézary syndrome
British Journal of Haematology, EarlyView.Summary Mycosis fungoides (MF) and Sézary syndrome (SS) are the most common cutaneous T‐cell lymphomas, arising from mature CD4+ memory T cells. Diagnosis is complex and relies on clinicopathological correlation, immunophenotyping and molecular clonality testing, while management is stage‐adapted, with potentially curative outcomes achievable only in ...
Francisco Martins, Joana Calvão
wiley +1 more source
Recent progress in mitochondria-targeted drug and drug-free agents for cancer therapy [PDF]
, 2019 The mitochondrion is a dynamic eukaryotic organelle that controls lethal and vital functions of the cell. Being a critical center of metabolic activities and involved in many diseases, mitochondria have been attracting attention as a potential target for
Jeena, M.T. +3 more
core +1 more source
British Journal of Haematology, EarlyView.Renal dysfunction represents a possible underrecognized complication of symptomatic WM; this condition correlates with adverse global and disease‐specific clinical outcomes. Summary The prognostic significance of impaired renal function in Waldenström macroglobulinaemia (WM) remains poorly defined.
Nicolò Danesin +27 more
wiley +1 more source
Quality of life of patients with chronic lymphocytic leukaemia in the Netherlands: results of a longitudinal multicentre study [PDF]
, 2015 Purpose: To describe the health-related quality of life (HRQoL) of an unselected population of patients with chronic lymphocytic leukaemia (CLL) including untreated patients. Methods: HRQoL was measured by the EORTC QLQ-C30 including the CLL16 module, EQ-
Daenen, S.M.G.J. (Simon) +15 more
core +1 more source
Journal of Cutaneous Pathology, EarlyView.ABSTRACT Cutaneous crystal‐storing histiocytosis (CSH) is an extremely rare histopathologic finding of histiocytes accumulating crystals of immunoglobulin or paraproteins, often associated with lymphoplasmacytic malignancies. It commonly presents in a wide age range of both female and male adults with a history of a lymphoproliferative disorder ...
Ashton Arlen +3 more
wiley +1 more source
Hybrid inhibitors of DNA and HDACs remarkably enhance cytotoxicity in leukaemia cells
Journal of Enzyme Inhibition and Medicinal Chemistry, 2020 Chlorambucil is a nitrogen mustard-based DNA alkylating drug, which is widely used as a front-line treatment of chronic lymphocytic leukaemia (CLL). Despite its widespread application and success for the initial treatment of leukaemia, a majority of ...
Yoojin Song +4 more
doaj +1 more source
Frontiers in Oncology, 2020 Previous studies investigated the efficacy and the safety of bendamustine (B) vs. chlorambucil (Chl) associated with rituximab (R) in fludarabine-ineligible patients with treated and untreated chronic lymphocytic leukemia (CLL).
Francesco Autore +19 more
doaj +1 more source