Results 221 to 230 of about 242,404 (349)

Development and Structural Characterization of UTE‐156, a Covalent Inhibitor of the VCP/p97 AAA+ ATPase

open access: yesAdvanced Science, Volume 13, Issue 25, 4 May 2026.
The AAA+ ATPase Valosin‐containing protein (VCP/p97) regulates protein homeostasis by unfolding ubiquitinated substrates. Here, we describe UTE‐156, a novel irreversible covalent inhibitor that modifies Cys522 in the D2 ATPase motor domain. Although its pharmacochemical limitations preclude immediate therapeutic use, UTE‐156 serves as a valuable ...
Daniela Tamayo‐Jaramillo   +8 more
wiley   +1 more source

Multi‐Targeting Non‐Specific Genome Engineering in Bacteria

open access: yesAdvanced Science, Volume 13, Issue 25, 4 May 2026.
In this study, we provide the first case to use the multi‐targeting integrase (MTI) systems in bacteria and develop a host‐independent generalizable approach, MNGE (Multi‐targeting Non‐specific Genome Engineering), for multi‐copy and random integration of metabolic genes or pathways in both Gram‐positive and Gram‐negative bacteria, which will ...
Runze Sun   +7 more
wiley   +1 more source

Enhanced Sensitivity of a Modified Quaking‐Induced Conversion Diagnostic Test for the Broad Detection of Sporadic and Inherited Prion Diseases: A Retrospective Study

open access: yesAnnals of Neurology, Volume 99, Issue 5, Page 1303-1314, May 2026.
Objective Quaking‐induced conversion (QuIC) tests, which detect prion‐seeding activity in cerebrospinal fluid (CSF), have markedly advanced the antemortem diagnosis of prion diseases such as Creutzfeldt‐Jakob disease (CJD). These tests provide high diagnostic accuracy and enable timely differentiation from other rapidly progressive neurodegenerative ...
Jennifer Myskiw   +13 more
wiley   +1 more source

Apathy in the elderly: an atypical manifestation of spotted fever rickettsioses. [PDF]

open access: yesBMC Geriatr
Kularatne SA   +7 more
europepmc   +1 more source

A New Conditional Transcription Factor for Use in Toxoplasma Gondii

open access: yesBiotechnology Journal, Volume 21, Issue 5, May 2026.
Graphical Abstract and Lay Summary A new conditional transcription factor (CTF) for Toxoplasma gondii reversibly regulates a reporter gene, achieving an outstanding signal‐to‐noise ratio. Gene expression is robust in the absence and nearly abolished in the presence of rapamycin, and the tool's modular design will facilitate application to varied genes ...
Mohammad Farouq Sharifpour   +12 more
wiley   +1 more source

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