Results 41 to 50 of about 901,749 (313)

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

Molecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma, Sophia M. Orbach, Kate V. Griffin, Kathryn Kang, Yining Zhang, Rebecca S. Pereles, Ian A. Schrack, Guillermo Escalona, Jacqueline S. Jeruss, Lonnie D. Shea   +9 more
wiley   +1 more source

Chloride ions evoke taste sensations by binding to the extracellular ligand-binding domain of sweet/umami taste receptors

eLife, 2023
Salt taste sensation is multifaceted: NaCl at low or high concentrations is preferably or aversively perceived through distinct pathways. Cl− is thought to participate in taste sensation through an unknown mechanism. Here, we describe Cl− ion binding and
Nanako Atsumi, Keiko Yasumatsu, Yuriko Takashina, Chiaki Ito, Norihisa Yasui, Robert F Margolskee, Atsuko Yamashita   +6 more
doaj   +1 more source

Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management

Molecular Oncology, EarlyView.
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez, Asieh Naderi, Kim‐Tuyen Huynh‐Dam, Vitali Sikirzhytski, Ioulia Chatzistamou, Hippokratis Kiaris   +5 more
wiley   +1 more source

Synthesis and structures of Cu-Cl-M adducts (M=Zn, Sn, Sb)

Main Group Metal Chemistry, 2014
The novel bimetallic adducts [(Ph3P)2CuCl]2.ZnCl2 (1), {[(Me3P)CuCl]2.ZnCl2}n (2), [(Me3P)4Cu]+[(Me3P)2Cu(Cl)2ZnCl2]- (3), (Ph3P)2CuCl.SnCl2 (4), (Me3P)3CuSnCl3 (5), [(Ph3P)2CuCl.SbCl3]2 (6) and (Ph3P)3CuCl.SbCl3 (7) have been synthesized from ...
Kociok-Köhn Gabriele, Mahon Mary F., Molloy Kieran C., Sudlow Anna L.   +3 more
doaj   +1 more source

Teores de cloretos, lactose e índice cloretos/lactose na secreção láctea de bovinos da raça Jersey no primeiro mês da lactação Chloride and lactose contents and chloride/lactose ratio in milk from Jersey cows in the first month of lactation

Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2009
Avaliou-se a influência do período colostral nos teores lácteos de cloretos, lactose e do índice cloretos/lactose. Foram colhidas 418 amostras de leite provenientes de glândulas mamárias sadias, e que não apresentavam crescimento bacteriano ao exame ...
R.F.S. Raimondo, D.B. Birgel, J.P.E. Saut, E.R. Komninou, E.H. Birgel Junior   +4 more
doaj   +1 more source

ON THE EFFECTS OF CHLORIDE OF ZINC, AND CHLORIDE OF LEAD, [PDF]

The Lancet
n ...
openaire   +3 more sources

Exploring the role of cyclin D1 in the pathogenesis of multiple myeloma beyond cell cycle regulation

Molecular Oncology, EarlyView.
Cyclin D1 overexpression altered the cell adhesion pathway, while cyclin D2 upregulation had less impact on pathway enrichment analysis. Multiple myeloma (MM) patients with cyclin D1 overexpression showed reduced CD56 expression and increased circulating tumor cells (CTC) levels, suggesting that cyclin D1 may contribute to MM cell dissemination ...
Ignacio J. Cardona‐Benavides, Sara Cristobal‐Vargas, Cristina De Ramón, Elizabeta A. Rojas, Irena Misiewicz‐Krzeminska, Isabel Isidro, José Juan Pérez, Bruno Paiva, Noemi Puig, Miguel Alcoceba, María‐Victoria Mateos, Luis A. Corchete, Myriam Cuadrado, Norma C. Gutiérrez   +13 more
wiley   +1 more source

Modification of aluminium alloys with rare metals – the basis for advanced materials in construction and transport

Нанотехнологии в строительстве, 2016
The method of process powder injection into aluminum melt shows much promise. Scandium is injected by the high-temperature exchange reaction between the salt melt and aluminum. The best salt compositions were selected.
Skachkov Vladimir Mikchaylovich, Yatsenko Sergey Pavlovich   +1 more
doaj   +1 more source

Calcium-Activated Chloride Channel ANO1/TMEM16A: Regulation of Expression and Signaling

Frontiers in Physiology, 2020
Anoctamin-1 (ANO1), also known as TMEM16A, is the most studied member of anoctamin family of calcium-activated chloride channels with diverse cellular functions.
Nickolai O. Dulin
doaj   +1 more source

Point-of-Care Testing to Differentiate Various Acid–Base Disorders in Chronic Kidney Disease

Diagnostics, 2023
Background: Normal-anion-gap metabolic acidosis (AGMA) and high-anion-gap metabolic acidosis (HAGMA) are two forms of metabolic acidosis, which is a common complication in patients with chronic kidney disease (CKD).
Tomasz Gołębiowski, Sławomir Zmonarski, Wiktoria Rożek, Mateusz Powązka, Patryk Jerzak, Maciej Gołębiowski, Mariusz Kusztal, Piotr Olczyk, Jakub Stojanowski, Krzysztof Letachowicz, Mirosław Banasik, Andrzej Konieczny, Magdalena Krajewska   +12 more
doaj   +1 more source