Results 51 to 60 of about 2,011,838 (343)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

1-Allyl-2-methylpyridinium chloride

IUCrData, 2017
The title molecular salt, C9H12N+·Cl−, was obtained by reaction of 2-methylpyridine and allyl chloride. A network of C—H...Cl hydrogen bonds is observed in the crystal structure.
Gino Bentivoglio, Gerhard Laus, Volker Kahlenberg, Thomas Röder, Herwig Schottenberger   +4 more
doaj   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Regression-based machine learning models for nitrate and chloride prediction in surface water in a small agricultural sand plain sub-watershed in southwestern Ontario, Canada

Frontiers in Environmental Science
Machine learning (ML) models have proven to be an efficient technique for better understanding and quantification of surface water quality, especially in agricultural watersheds where considerable anthropogenic activities occur.
Ahmed Elsayed, Ahmed Elsayed, Jana Levison, Andrew Binns, Marie Larocque, Pradeep Goel   +5 more
doaj   +1 more source

Phosphonium chloride for thermal storage [PDF]

, 1972
Development of systems for storage of thermal energy is discussed. Application of phosphonium chloride for heat storage through reversible dissociation is described.
Heimlich, P. F., Sutton, J. G., Tepper, E. H.   +2 more
core   +1 more source

Self-machinery?: steel trusses and the management of ruptures in eighteenth-century Europe [PDF]

, 2013
: Effectiveness Of Rice Husk Ash And Poly Aluminum Chloride In Reducing Exposure Colour Liquid Waste Industry Sasirangan. Sasirangan fabric industry is the textile of industry in Kalimantan Selatan produce wastewater of dyeing cloth sasirangan process ...
A., Syarifudin, Hakim, Luqman Nur, Hamzani, Sulaiman   +2 more
core   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Synthesis and structures of Cu-Cl-M adducts (M=Zn, Sn, Sb)

Main Group Metal Chemistry, 2014
The novel bimetallic adducts [(Ph3P)2CuCl]2.ZnCl2 (1), {[(Me3P)CuCl]2.ZnCl2}n (2), [(Me3P)4Cu]+[(Me3P)2Cu(Cl)2ZnCl2]- (3), (Ph3P)2CuCl.SnCl2 (4), (Me3P)3CuSnCl3 (5), [(Ph3P)2CuCl.SbCl3]2 (6) and (Ph3P)3CuCl.SbCl3 (7) have been synthesized from ...
Kociok-Köhn Gabriele, Mahon Mary F., Molloy Kieran C., Sudlow Anna L.   +3 more
doaj   +1 more source

Study on the Removal of Chloride Ions in an Acidic Solution of Zinc Smelting by Green Method

Separations, 2023
In the process of zinc smelting, when the chloride ion concentration exceeds 100 mg/L, it continuously corrodes the electrode plate and affects the stability of the electrodeposition process.
Zhiwen Xiao, Jing Li, Guang Fu, Xinpei Li, Likun Gu, Chaobo Zhang, Te Zhang, Weibo Yin, Dianchuan Liu, Junchang Liu   +9 more
doaj   +1 more source