Results 71 to 80 of about 1,158,094 (296)
Children, 2022 Gamma-amino butyric acid (GABA) is well known to help elevate pancreatic β cell vitality and insulin levels in blood. GABA works via a coupling with GABA receptors; thus, the concentration of GABAA receptors on the plasma membrane of β cells appears to ...
Eung-Kwon Pae +2 more
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
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Calcium-Activated Chloride Channel ANO1/TMEM16A: Regulation of Expression and Signaling
Frontiers in Physiology, 2020 Anoctamin-1 (ANO1), also known as TMEM16A, is the most studied member of anoctamin family of calcium-activated chloride channels with diverse cellular functions.
Nickolai O. Dulin
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Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Materiales de Construccion, 2016 This paper presents the mechanical performance and durability of concrete with water/cement (w/c) ratios of 0.30 and 0.60 containing cactus mucilage and brown marine seaweed extract solutions (at 0.5° Brix concentrations). Cylindrical specimens (100 mm x
E. F. Hernández +2 more
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Plants, 2020 Salt stress is one of the most impactful abiotic stresses that plants must cope with. Plants’ ability to tolerate salt stress relies on multiple mechanisms, which are associated with biomass and yield reductions.
Pasquale Giorio +8 more
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ClC-5 Downregulation Induces Osteosarcoma Cell Apoptosis by Promoting Bax and tBid Complex Formation
Frontiers in Oncology, 2021 Osteosarcoma is the most common malignant bone tumor. Chloride (Cl−) channels-mediated Cl− movement plays an important role in regulating the functions of various cancer cells, but its role in osteosarcoma remains unclear.
Fei Peng +3 more
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Phospho-dependent modulation of potassium chloride co-transporter KCC2 [PDF]
, 2009 The neuronal-specific potassium chloride co-transporter 2, KCC2, is a major chloride extruder in brain. The expression of KCC2 during neuronal development is fundamental to the switch of GABAergic response from excitatory to inhibitory. Malfunction of
Lee, H.C.
core
FEBS Open Bio, EarlyView.In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin +12 more
wiley +1 more source