Results 61 to 70 of about 2,454,384 (403)

GABAergic synaptic transmission regulates calcium influx during spike-timing dependent plasticity

Frontiers in Synaptic Neuroscience, 2010
Coincident pre- and postsynaptic activity of hippocampal neurons alters the strength of gamma-aminobutyric acid (GABAA)-mediated inhibition through a Ca2+-dependent regulation of cation-chloride cotransporters.
Trevor Balena, Brooke A Acton, Melanie A Woodin   +2 more
doaj   +1 more source

Hypochloremia Is a Noninvasive Predictor of Mortality in Pulmonary Arterial Hypertension

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Pulmonary arterial hypertension (PAH) is a lethal disease. In resource‐limited countries PAH outcomes are worse because therapy costs are prohibitive.
Kurt W. Prins, Rajat Kalra, Lauren Rose, Tufik R. Assad, Stephen L. Archer, Navkaranbir S. Bajaj, E. Kenneth Weir, Sasha Z. Prisco, Marc Pritzker, Pamela L. Lutsey, Evan L. Brittain, Thenappan Thenappan   +11 more
doaj   +1 more source

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

Influences of chloride immersion on zeta potential and chloride in concentration of cement-based materials [PDF]

, 2015
In this paper, the zeta potential of freshly mixed cement paste and hardened cement pastes, as well as the concentration index, was measured. The influences of chloride concentration in mixing water and slag content on zeta potential of freshly mixed ...
De Schutter, Geert, Hu, Xiang, Shi, Caijun   +2 more
core  

1-Allyl-2-methylpyridinium chloride

IUCrData, 2017
The title molecular salt, C9H12N+·Cl−, was obtained by reaction of 2-methylpyridine and allyl chloride. A network of C—H...Cl hydrogen bonds is observed in the crystal structure.
Gino Bentivoglio, Gerhard Laus, Volker Kahlenberg, Thomas Röder, Herwig Schottenberger   +4 more
doaj   +1 more source

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

Molecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić, Florian Lüke, Steffi Treitschke, Andrea Coluccio, Martin Hoffmann, Giancarlo Feliciello, Adithi Ravikumar Varadarajan, Xin Lu, Kathrin Weidele, Catherine Botteron, Silvia Materna–Reichelt, Felix Keil, Katja Evert, Florian Weber, Thomas Schamberger, Michael Althammer, Jirka Grosse, Dirk Hellwig, Christian Schulz, Stephan Seitz, Peter Ugocsai, Anke Schlenska‐Lange, Roman Mayr, Ulrich Kaiser, Wolfgang Dietmaier, Bernhard Polzer, Jens Warfsmann, Kamran Honarnejad, Tobias Pukrop, Daniel Heudobler, Christoph A. Klein, Christian Werno   +31 more
wiley   +1 more source

Comparison of material properties of SCC concrete with steel fibres related to ingress of chlorides [PDF]

, 2020
The paper focuses on the evaluation of chloride ion diffusion coefficient of self-compacting concrete with steel fibre reinforcement. The reference concrete from Ordinary Portland Cement (OPC) and Self-Compacting Concrete (SCC) with several values of ...
Konečný, Petr, Lehner, Petr, Ponikiewski, Tomasz   +2 more
core   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Phosphonium chloride for thermal storage [PDF]

, 1972
Development of systems for storage of thermal energy is discussed. Application of phosphonium chloride for heat storage through reversible dissociation is described.
Heimlich, P. F., Sutton, J. G., Tepper, E. H.   +2 more
core   +1 more source

secCl is a cys-loop ion channel necessary for the chloride conductance that mediates hormone-induced fluid secretion in Drosophila [PDF]

, 2019
Organisms use circulating diuretic hormones to control water balance (osmolarity), thereby avoiding dehydration and managing excretion of waste products.
Dent, J., Drapeau, P., Feingold, D., Knogler, L., Nilson, L., O'Donnell, M., Starc, T.   +6 more
core   +2 more sources