Results 21 to 30 of about 470,990 (120)

Topical Chlormethine Gel in the Treatment of Lymphomatoid Papulosis: A Case Report and Literature Review. [PDF]

J Clin Med
Background: Lymphomatoid papulosis (LyP) is a primary cutaneous CD30-positive T-cell lymphoproliferative disorder presenting with self-healing erythematous papulonodular lesions that may ulcerate and scar. Treatment varies by lesion extent, location, and
Teoli M, Caviglia M, Rega F, Barbieri L, Ardigò M, Mandel VD.   +5 more
europepmc   +5 more sources

Mechanism of action of chlormethine gel in mycosis fungoides [PDF]

Journal of the European Academy of Dermatology and Venereology, Volume 37, Issue 9, Page 1739-1748, September 2023., 2023
Abstract Mycosis fungoides (MF), the most common type of cutaneous T‐cell lymphoma, is characterized by proliferation of malignant skin‐tropic T cells. Progression from early‐stage disease (skin patches and/or plaques) to more advanced stages (cutaneous tumours, erythroderma or extracutaneous involvement) occurs slowly and can be discontinuous ...
E. Guenova, P. L. Ortiz‐Romero, B. Poligone, C. Querfeld   +3 more
wiley   +4 more sources

The optimal use of chlormethine gel for mycosis fungoides: An expert consensus from Germany, Austria and Switzerland (DACH region)

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, 2022
In Europe chlormethine gel is licensed for the management of patients with mycosis fungoides of all stages. However, the optimal regimen regarding frequency and dosing as well as combination and maintenance therapy is not well established.
Klemke, C.D., Max Schlaak, Claus‐Detlev Klemke, Jonak, C., Jan P. Nicolay, Marion Wobser, Trautinger, F., Assaf, C., Booken, N., Franz Trautinger, Edgar Dippel, Chalid Assaf, Dippel, E., Emmanuella Guenova, Constanze Jonak, Guenova, E., Nina Booken, Nicolay, J.P., Wobser, M., Schlaak, M.   +19 more
core   +3 more sources

Clinical Validation of Imaging Biomarkers in Mycosis Fungoides. [PDF]

Exp Dermatol
ABSTRACT The composite index lesion severity (CAILS) score is used to monitor disease and therapeutic response in mycosis fungoides (MF), but is limited by interobserver variability and low sensitivity. Emerging imaging techniques, such as multispectral imaging (MSI), colourimetry and laser speckle contrast imaging (LSCI), offer objective alternatives ...
Wind SS, Beljaards ESM, Rijneveld R, Bruijnincx L, der Kolk TN, Jansen MAA, Yavuz Y, de Kam M, Burggraaf J, Klarenbeek N, Bosch J, Quint KD, Vermeer MH, Rissmann R, Next‐Generation ImmunoDermatology Consortium (NGID).   +14 more
europepmc   +2 more sources

Practical recommendations for therapy and monitoring of mogamulizumab patients in Germany. [PDF]

J Dtsch Dermatol Ges
Summary Mycosis fungoides (MF) and Sézary syndrome (SS) are the most common subtypes of the heterogeneous group of cutaneous T‐cell lymphomas (CTCL). With the expansion of the biologic treatment landscape, new treatment options have become available in recent years, most notably the C‐C chemokine receptor 4 (CCR4)‐directed monoclonal antibody ...
Assaf C, Booken N, Dippel E, Dobos G, Eich HT, Klemke CD, Mitteldorf C, Nicolay JP, Theurich S, Wobser M, Stadler R.   +10 more
europepmc   +2 more sources

Chlormethine gel is effective for the treatment of skin lesions in patients with early- and late-stage mycosis fungoides in clinical practice

Journal of the European Academy of Dermatology and Venereology, 2022
Background: Chlormethine gel is a skin-directed therapy used for patients with mycosis fungoides (MF) that showed a favourable risk/benefit profile in a randomized clinical trial. Currently, data on chlormethine gel use in real-world settings are limited.
Nikolaou, V., Georgiou, E., Lampadaki, K., Patsatsi, A., Koumourtzis, M., Dalamaga, M., Papadavid, E., Marinos, L., Stratigos, A.   +8 more
core   +4 more sources

Ultra-high-frequency Ultrasound in the Objective Assessment of Chlormethine Gel Efficacy: A Case Report [PDF]

Acta dermatovenerologica Croatica : ADC
: Mycosis fungoides (MF) represent the most frequent form of cutaneous T-cell lymphoma (CTCL). Chlormethine gel has been approved as first-line therapy in MF.
Bevilacqua, Matteo, Dini, Valentina, Romanelli, Marco, Michelucci, Alessandra, Janowska, Agata, Fidanzi, Cristian   +5 more
core   +7 more sources

Erfolgreiche Behandlung einer lymphomatoiden Papulose mit Chlormethin‐Gel

JDDG: Journal der Deutschen Dermatologischen Gesellschaft
JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 22, Issue 6, Page 826-828, June 2024.
Tassilo Dege, Isabel Netzer, Katharina Strobel, Matthias Goebeler, Marion Wobser   +4 more
wiley   +2 more sources

Systemic Targeted Therapies in Patients with Relapsed/Refractory Advanced Stage Cutaneous T-cell Lymphoma: A Real-world Single-centre Case Series [PDF]

Acta Dermato-Venereologica
Cutaneous T-cell lymphomas are a heterogeneous group of non-Hodgkin lymphomas. Early stages are often controlled with skin-directed therapy, such as topical corticosteroids, topical chlormethine gel, or UV therapy, whereas advanced stages often warrant a
Signe Hedebo, Martin B. Pedersen, Lise M. Lindahl, Aska Drjlevic-Nielsen, Claus Johansen, Francesco d'Amore, Lars Iversen, Rikke Bech   +7 more
doaj   +2 more sources

Topical chlormethine gel in the treatment of mycosis fungoides: A single‐center real‐life experience and systematic review of the literature

Dermatologic Therapy, 2022
Gel formulation of chlormethine (CG) has gained a preeminent role among therapies available for mycosis fungoides (MF). To evaluate the frequency of use of CG for MF treatment and to determine the limits and potentialities of CG in a real-world setting ...
Laghi, Alessandro, Sansone, Massimo, Teoli, Miriam, Ardigò, Marco, Mandel, Victor Desmond, La Malfa, Antonia Marina, Franceschini, Chiara, Musicco, Felice   +7 more
core   +3 more sources