Chloromethylisothiazolinone induces ER stress-induced stress granule formation in human keratinocytes [PDF]
Animal Cells and Systems, 2023 Chloromethylisothiazolinone (CMIT), a humidifier disinfectant, is known to be toxic to the respiratory system. While the toxic effect of CMIT on the lungs has been widely investigated, its effect on the skin is well unknown.
Da-Min Jung, Kee K. Kim, Eun-Mi Kim
doaj +4 more sources
A Study on the Behavior Patterns of Liquid Aerosols Using Disinfectant Chloromethylisothiazolinone/Methylisothiazolinone Solution [PDF]
Molecules, 2021 This study evaluates the behavioral characteristics of components (methylisothiazolinone (MIT) and chloromethylisothiazolinone (CMIT)) contained in disinfectant solutions when they convert to liquid aerosols.
Yong-Hyun Kim +2 more
doaj +5 more sources
Absence of Adverse Effects on Pulmonary Histopathology and Functions Following Inhalation Exposure to Chloromethylisothiazolinone/Methylisothiazolinone [PDF]
ToxicsIn South Korea, issues have been raised regarding exposure to humidifier disinfectant products containing certain chemicals postulated to induce lung diseases in consumers.
Sam Kacew, Esref Demir
doaj +3 more sources
Polyhexamethylene guanidine phosphate, chloromethylisothiazolinone, and particulate matter are dispensable for stress granule formation in human airway epithelial cells [PDF]
Animal Cells and Systems, 2021 Environmental risk factors are recognized as threats to public health. Stress granules (SGs) are non-membranous assemblies of mRNAs and proteins expressed in response to various stressors to promote cell survival. In this study, SG formation was examined
Arnoldo Cambronero-Urena +4 more
doaj +5 more sources
MTF1 Is Essential for the Expression of MT1B, MT1F, MT1G, and MT1H Induced by PHMG, but Not CMIT, in the Human Pulmonary Alveolar Epithelial Cells [PDF]
Toxics, 2021 The inhalation of humidifier disinfectants (HDs) is linked to HD-associated lung injury (HDLI). Polyhexamethylene guanidine (PHMG) is significantly involved in HDLI, but the correlation between chloromethylisothiazolinone (CMIT) and HDLI remains ...
Sang-Hoon Jeong +13 more
doaj +2 more sources
Eye irritation tests of polyhexamethylene guanidine phosphate (PHMG) and chloromethylisothiazolinone/methylisothiazolinone (CMIT/MIT) using a tissue model of reconstructed human cornea-like epithelium [PDF]
Environmental Health and Toxicology, 2019 Disinfectants including polyhexamethylene guanidine phosphate (PHMG) and mixtures of chloromethylisothiazolinone/ methylisothiazolinone (CMIT/MIT) have been widely used in Korea to prevent microbial growth in the humidifier water, which triggered an ...
Juyoung Park, Handule Lee, Kwangsik Park
doaj +4 more sources
Toxicological evidence integration to confirm the biological plausibility of the association between humidifier disinfectant exposure and respiratory diseases using the AEP-AOP framework [PDF]
Epidemiology and HealthOBJECTIVES Exposure to humidifier disinfectants has been linked to respiratory diseases, including interstitial lung disease, asthma, and pneumonia. Consequently, numerous toxicological studies have explored respiratory damage as both a necessary and ...
Ha Ryong Kim +10 more
doaj +2 more sources
The Contact Allergen Methylisothiazolinone (MIT) is a Potent Activator of the TRPA1 Ion Channel. [PDF]
Pharmacol Res PerspectABSTRACT Methylisothiazolinone (MIT) is a known inducer of allergic contact dermatitis that is used as a preservative and a biocide in consumer products. Transient receptor potential ankyrin 1 (TRPA1) is a non‐selective cation channel expressed in neurons and in some nonneuronal cells including keratinocytes.
Mäki-Opas I +4 more
europepmc +2 more sources
A comprehensive study of deaths due to exposure to humidifier disinfectant in Korea: focusing on medical records, assessment of exposure to humidifier disinfectants, and causes of death [PDF]
Epidemiology and Health, 2021 OBJECTIVES We aimed to determine the characteristics of the deceased victims of deaths caused by exposure to humidifier disinfectants, and present the distribution of the victims’ data submitted for damage application, demographic characteristics ...
Yeong Jun Ju +5 more
doaj +1 more source
Outbreak of occupational allergic contact dermatitis from a smartphone screen protector glue
Contact Dermatitis, Volume 87, Issue 1, Page 53-61, July 2022., 2022 We describe an occupational allergic contact dermatitis outbreak likely from 4‐acryloylmorpholine (ACMO) in a smartphone protector glue involving 13 female workers of a phone chain store across Spain. According to the label, the glue contained isobornyl acrylate (IBOA) among other ingredients, but patch tests with IBOA were negative in 8 of 13 cases. A
Francisca Herreros‐Montejano +11 more
wiley +1 more source