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Quantification of N -methylmalonamic acid in urine as metabolite of the biocides methylisothiazolinone and chloromethylisothiazolinone using gas chromatography-tandem mass spectrometry

Journal of Chromatography B, 2017
Methylisothiazolinone and the mixture of chloromethylisothiazolinone/methylisothiazolinone (MCI/MI, 3:1) are widespread biocides used in cosmetic and household products. Due to their skin permeability, they might be taken up by the general population via use of products containing these biocides. As both compounds are known skin sensitizers, the use of
T, Schettgen, J, Bertram, T, Kraus
openaire   +2 more sources

Metabolite analysis of 14C-labeled chloromethylisothiazolinone/methylisothiazolinone for toxicological consideration of inhaled isothiazolinone biocides in lungs

Chemosphere
5-Chloro-2-methyl-4-isothiazolin-3-one (CMIT) and 2-methyl-4-isothiazolin-3-one (MIT) used as preservatives in various products, including humidifier disinfectants, presents substantial health hazards. This research delves into the toxicological assessments of CMIT/MIT in the respiratory system using animal models. Through the synthesis of radiolabeled
Jung Eun Park   +5 more
openaire   +2 more sources

Evaluating the comparative MT1B, MT1F, MT1G, and MT1H expression in human pulmonary alveolar epithelial cells treated with polyhexamethylene guanidine-phosphate, chloromethylisothiazolinone/methylisothiazolinone, oligo(2-(2-ethoxy)ethoxyethyl guanidinium chloride, benzalkonium chloride, and sodium dichloroisocyanurate

Molecular & Cellular Toxicology, 2022
Jaeyoung Kim   +13 more
openaire   +1 more source

Animal Cells and Systems

Animal Cells and Systems, 2023
Kee K Kim, Eun-Mi Kim
exaly  

Quantification of -methylmalonamic acid in urine as metabolite of the biocides methylisothiazolinone and chloromethylisothiazolinone using gas chromatography-tandem mass spectrometry

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 2017
Jens Bertram, Thomas Schettgen
exaly  

Translating human biomonitoring data into quantitative exposure and risk estimates for chloromethylisothiazolinone and methylisothiazolinone using a population pharmacokinetic model

Archives of Toxicology
Ji-Hun Jang   +6 more
openaire   +1 more source

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