Results 91 to 100 of about 125,568 (336)

The Antimalarial Chloroquine Reduces the Burden of Persistent Atrial Fibrillation

Frontiers in Pharmacology, 2019
In clinical practice, reducing the burden of persistent atrial fibrillation by pharmacological means is challenging. We explored if blocking the background and the acetylcholine-activated inward rectifier potassium currents (IK1 and IKACh) could be ...
Catalina Tobón, Laura C. Palacio, Bojjibabu Chidipi, Diana P. Slough, Thanh Tran, Nhi Tran, Michelle Reiser, Yu-Shan Lin, Bengt Herweg, Dany Sayad, Javier Saiz, Sami Noujaim   +11 more
doaj   +1 more source

Repurposing Drugs in Oncology (ReDO)—chloroquine and hydroxychloroquine as anti-cancer agents

ecancermedicalscience, 2017
Chloroquine (CQ) and hydroxychloroquine (HCQ) are well-known 4-aminoquinoline antimalarial agents. Scientific evidence also supports the use of CQ and HCQ in the treatment of cancer.
C. Verbaanderd, H. Maes, Marco B. E. Schaaf, Vikas P. Sukhatme, P. Pantziarka, V. Sukhatme, P. Agostinis, G. Bouche   +7 more
semanticscholar   +1 more source

DNA Nanoflower LYTACs Enable Efficient VEGF Degradation and Verteporfin Loading for Combined Therapy of Wet Age‐Related Macular Degeneration

Advanced Science, EarlyView.
An integrated approach that combines a DNA nanoflower VEGF degrader with photodynamic therapy is developed for the treatment of wet age‐related macular degeneration, which reduces the risk of VEGF reactivation‐induced CNV recurrence and minimizes the systemic side effects associated with photodynamic therapy.
Mengxuan Li, Yan Yue, Sijin Wu, Xinyu He, Jiayi Song, Shuwen Ma, Haokun Zhang, Chenyu Xu, Song Chen, Yanming Huang, Songbo Xie, Hua Yan   +11 more
wiley   +1 more source

Chloroquine sensitizes biofilms of Candida albicans to antifungal azoles

Brazilian Journal of Infectious Diseases, 2013
Biofilms formed by Candida albicans, a human pathogen, are known to be resistant to different antifungal agents. Novel strategies to combat the biofilm associated Candida infections like multiple drug therapy are being explored.
Ravikumar Bapurao Shinde, Jayant Shankar Raut, Nitin Mahendra Chauhan, Sankunny Mohan Karuppayil   +3 more
doaj   +1 more source

PPT1 Promotes Tumor Growth and Is the Molecular Target of Chloroquine Derivatives in Cancer.

Cancer Discovery, 2018
Clinical trials repurposing lysosomotropic chloroquine (CQ) derivatives as autophagy inhibitors in cancer demonstrate encouraging results, but the underlying mechanism of action remains unknown.
V. Rebecca, Michael C. Nicastri, C. Fennelly, Cynthia I Chude, J. Barber-Rotenberg, Amruta M Ronghe, Q. McAfee, N. McLaughlin, Gao Zhang, Aaron R. Goldman, Rani Ojha, Shengfu Piao, Estela Noguera-Ortega, Alessandra Martorella, Gretchen M. Alicea, J. J. Lee, L. Schuchter, Xiaowei Xu, M. Herlyn, R. Marmorstein, P. Gimotty, D. Speicher, J. Winkler, R. Amaravadi   +23 more
semanticscholar   +1 more source

OTUD6A in Airway Epithelial Cells Exacerbates Allergic Asthma by Promoting Airway Inflammation and Airway Remodeling Through Deubiquitination of hResistin/mRELMα

Advanced Science, EarlyView.
This study elucidates a novel mechanistic role of the deubiquitinase OTUD6A in asthma pathogenesis, uncovering its regulatory function in airway inflammation and airway remodeling through the stabilization of hResistin/mRELMα. This study offers a novel regulatory axis (OTUD6A‐hResistin/mRELMα) in asthma pathogenesis and OTUD6A inhibition as a potential
Weiting Pan, Xinru Xi, Wei Dai, Tingfang Xiao, Yeqing Chen, Xuanyu Chen, Xiangting Ge, Chengguang Zhao, Hui Zhang, Yali Zhang, Weixi Zhang   +10 more
wiley   +1 more source

Revisiting hydroxychloroquine and chloroquine for patients with chronic immunity-mediated inflammatory rheumatic diseases [PDF]

, 2020
Edgard Torres dos Reis Neto, Adriana María Kakehasi, Marcelo Antônio Amaro Pinheiro, Gilda Aparecida Ferreira, Cláudia Diniz Lopes Marques, Lícia Maria Henrique da Mota, Eduardo dos Santos Paiva, Gecilmara Salviato Pileggi, Emília Inoue Sato, Ana Paula Monteiro Gomides, Ricardo Machado Xavier, José Roberto Provenza   +11 more
openalex   +1 more source

Targeting the GPX4–FUNDC1 Interaction with Magnesium Lithospermate B Attenuates Sepsis‐Associated Lung Injury

Advanced Science, EarlyView.
The diagram depicts the endothelial‐protective mechanism of magnesium lithospermate B (MLB) in sepsis‐associated lung injury. MLB binds GPX4 at Gly79, disrupts its interaction with FUNDC1, prevents mitophagy‐mediated GPX4 degradation, restores mitophagic flux, reduces ROS, and limits ferroptosis.
Zhixi Li, Chang Liu, Zhaoxue Ma, Dongyou Zheng, Renkai Wang, Yongjing Yu, Guangmin Chen, Chenglong Li, Yue Bu, Hang Cao, Bing Zhang   +10 more
wiley   +1 more source

Systemic chloroquine intoxication: a hint from the peripheral blood smear [PDF]

, 2020
Marc Pineton de Chambrun, Catherine Settegrana, Karim Dorgham, Odile Fenneteau, Jean‐Michel Goujon, Alexis Mathian, Zahir Amoura   +6 more
openalex   +1 more source

Chloroquine as a Potential Treatment and Prevention Measure for the 2019 Novel Coronavirus: A Review

, 2020
There is a long trail of research studies testing the in vitro and in vivo efficacy of chloroquine and its derivatives in treating and preventing infection by various coronavirus species.
J. Kearney
semanticscholar   +1 more source