Results 81 to 90 of about 108,092 (308)

Mitochondrial SLC25A46 Rewires Fatty Acid Oxidation to Promote Cell Proliferation and Ferroptosis Evasion in Ovarian Cancer by Stabilizing CACT

Advanced Science, EarlyView.
Mitochondrial SLC25A46 is upregulated in ovarian cancer (OC) and correlates with poor prognosis. SLC25A46 stabilizes CACT to activate fatty acid oxidation, increasing ATP and NADPH production to drive cell proliferation and ferroptosis evasion. SLC25A46 silencing sensitizes OC cells to ferroptosis and carboplatin, offering a promising therapeutic ...
Yunge Gao, Jiatao Hao, Xiaohong Zhang, Meiting Long, Yujing Feng, Xiaoyue Liu, Xuejian Li, Shujuan Liu, Xin Guo, Xiaohui Lv   +9 more
wiley   +1 more source

Concurrence of Plasmodium falciparum dhfr and crt mutations in northern Ghana. [PDF]

, 2005
BACKGROUND: Both chloroquine (CQ) and sulfadoxine-pyrimethamine (SP) are failing drugs in much of sub-Saharan Africa. Previous findings suggest an association between resistance to CQ and to SP in vivo, in vitro, and on the molecular level.
Bousema J Teun, Sauerwein, Robert W, Teunis A Eggelte, Bousema, J. Teun, Bienzle Ulrich, Bousema, J Teun, Ehrhardt, Stephan, Eggelte Teunis A, Mockenhaupt Frank P, Otchwemah, Rowland N., Ehrhardt Stephan, Otchwemah, Rowland N, Bienzle, Ulrich, Mockenhaupt, Frank P., Mockenhaupt, Frank P, J Teun Bousema, Rowland N Otchwemah, Eggelte, Teunis A, Eggelte, Teunis A., Ulrich Bienzle, Stephan Ehrhardt, Otchwemah Rowland N, Sauerwein Robert W, Frank P Mockenhaupt, Robert W Sauerwein, Sauerwein, Robert W.   +25 more
core   +1 more source

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

Advanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh   +9 more
wiley   +1 more source

In Vivo Anti-Malarial Activity of Heracleum persicum Fruit Extract, in Combination with Chloroquine against Chloroquine–Sensitive Strain of Plasmodium berghei

Iranian Journal of Public Health, 2018
Background: We evaluated the anti-malarial activity of Heracleum persicum individually and in combination with chloroquine. Methods: This study was conducted at the School of Public Health, Tehran University of Medical Sciences, Tehran, Iran in 2015 ...
Nahideh MAZHARI, Mehdi NATEGHPOUR, Peyman HEYDARIAN, Leila FARIVAR, Effat SOURI, Afsaneh MOTEVALLI HAGHI   +5 more
doaj  

CHLOROQUINE RESISTANCE IN MALARIA: A DEFICIENCY OF CHLOROQUINE BINDING [PDF]

Proceedings of the National Academy of Sciences, 1969
Chloroquine- 14 C was used to study the processes which concentrate chloroquine in mouse red blood cells infected with chloroquine-sensitive or with chloroquine-resistant Plasmodium berghei . The initial rates of uptake and exchange of chloroquine-
openaire   +2 more sources

Severe Chloroquine Retinopathy without Bull’s Eye Maculopathy

, 2014
Chloroquine has long been used for the treatment of autoimmune diseases, beside its use for treatment and prevention of malaria. We herein report a chloroquine retinopathy case with a history of 250 mg per day chloroquine treatment for SLE for the last ...
Murat Küçükevcilioğlu, Cem Özgönül, Gökçen Gökçe   +2 more
core   +1 more source

Activity of piperaquine and other 4-aminoquinoline antiplasmodial drugs against chloroquine-sensitive and resistant blood-stages of Plasmodium falciparum. Role of beta-haematin inhibition and drug concentration in vacuolar water- and lipid-phases. [PDF]

, 2007
Chloroquine (CQ), a 4-aminoquinoline, accumulates in acidic digestive vacuoles of the malaria parasite, preventing conversion of toxic haematin to beta-haematin.
Guy, R Kiplin, Warhurst, David C, Fivelman, Quinton L, Craig, John C, Adagu, Ipemida S, Madrid, Peter B   +5 more
core   +1 more source

Porcine Deltacoronavirus M Protein Binds NLRP3 to Promote Inflammasome Assembly via Competition with TRIM31

Advanced Science, EarlyView.
Porcine deltacoronavirus (PDCoV) infection induces severe intestinal inflammation and acute diarrhea in piglets, yet the molecular mechanism remains incompletely understood. The M protein activates NLRP3 inflammasome through dual mechanisms: direct binding to the NLRP3 LRR domain and disruption of TRIM31‐mediated K48‐linked ubiquitination.
Jinhui Hou, Fangfang Han, Anqi Liu, Yang Yu, Rui Zhao, Zhengting Shi, Yanrong Lv, Jinli Liu, Shaopo Zu, Zhanyong Wei, Jin Yuan, Hui Hu   +11 more
wiley   +1 more source

Isradipine – a calcium channel blocker – does not potentiate chloroquine antiplasmodial activity against Plasmodium falciparum

Parasite, 2005
Culturing fresh clinical isolates of P. falciparum and using the isotopic method, we tested separately chloroquine and isradipine – a calcium channel blocker –, and also the combination isradipine plus chloroquine.
Randrianarivelojosia M., Jambou R.
doaj   +1 more source

Chloroquine inhibits Ca2+ permeable ion channels-mediated Ca2+ signaling in primary B lymphocytes

Cell & Bioscience, 2017
Background Chloroquine, a bitter tastant, inhibits Ca2+ signaling, resulting in suppression of B cell activation; however, the inhibitory mechanism remains unclear.
Yi-Fan Wu, Ping Zhao, Xi Luo, Jin-Chao Xu, Lu Xue, Qi Zhou, Mingrui Xiong, Jinhua Shen, Yong-Bo Peng, Meng-Fei Yu, Weiwei Chen, Liqun Ma, Qing-Hua Liu   +12 more
doaj   +1 more source