Results 1 to 10 of about 28,420 (218)

Dietary para-aminobenzoic acid, uric acid, and antibiotics modulate the susceptibility of Anopheles darlingi and Anopheles albimanus to Plasmodium berghei [PDF]

Frontiers in Cellular and Infection Microbiology
BackgroundMalaria, caused by Plasmodium, is transmitted to humans through the bite of infected Anopheles mosquitoes. Anopheles darlingi and Anopheles albimanus are primary vectors in South and Central America, with An.
Breno A. Costa, Breno A. Costa, Raquel S. M. Godoy, Raquel S. M. Godoy, Lucas Henrique-Gomes, Rosa A. G. Santana, Silvia C. B. Justiniano, Stefanie C. P. Lopes, Stefanie C. P. Lopes, Wuelton M. Monteiro, Wuelton M. Monteiro, Gisely C. de Melo, Gisely C. de Melo, Nagila F. C. Secundino, Nagila F. C. Secundino, Nagila F. C. Secundino, Nagila F. C. Secundino, Paulo F. P. Pimenta, Paulo F. P. Pimenta, Paulo F. P. Pimenta, Paulo F. P. Pimenta   +20 more
doaj   +2 more sources

Continuous exposure to Plasmodium results in decreased susceptibility and transcriptomic divergence of the Anopheles gambiae immune system [PDF]

BMC Genomics, 2007
Background Plasmodium infection has been shown to compromise the fitness of the mosquito vector, reducing its fecundity and longevity. However, from an evolutionary perspective, the impact of Plasmodium infection as a selective pressure on the mosquito ...
Dimopoulos George, Dong Yuemei, Das Suchismita, Aguilar Ruth   +3 more
doaj   +3 more sources

Transcriptome analysis reveals a de novo DNA element that may interact with chromatin-associated proteins in Plasmodium berghei during erythrocytic development [PDF]

Scientific Reports
The life cycle of Plasmodium parasites involves intricate, multistage processes that are tightly regulated by stage-specific transcription factors. These factors bind to regulatory regions within gene promoters, enabling the precise expression of genes ...
Adaobi Okafor, Yagoub Adam, Benedikt Brors, Ezekiel Adebiyi   +3 more
doaj   +2 more sources

Extracellular ATP triggers proteolysis and cytosolic Ca²⁺ rise in Plasmodium berghei and Plasmodium yoelii malaria parasites [PDF]

Malaria Journal, 2012
Background Plasmodium has a complex cell biology and it is essential to dissect the cell-signalling pathways underlying its survival within the host. Methods Using the fluorescence resonance energy transfer (FRET) peptide substrate Abz-AIKFFARQ-EDDnp and
Cruz Laura, Juliano Maria, Budu Alexandre, Juliano Luiz, Holder Anthony A, Blackman Michael J, Garcia Célia RS   +6 more
doaj   +6 more sources

CSP ubiquitylation favours Plasmodium berghei survival during early liver stage infection [PDF]

Scientific Reports
The circumsporozoite protein (CSP), an essential protein that covers the surface of the Plasmodium sporozoite, is a key player in multiple stages of the parasite development within the mosquito and during interactions between sporozoites and mammalian ...
Sara J. S. Baptista, Aparajita Lahree, Sofia Marques, Inês Bento, João Mello-Vieira, António M. Mendes, Vanessa Zuzarte-Luís, Maria M. Mota   +7 more
doaj   +2 more sources

Constitutive expression of Cas9 and rapamycin-inducible Cre recombinase facilitates conditional genome editing in Plasmodium berghei [PDF]

Scientific Reports
Malaria is caused by protozoan parasites of the genus Plasmodium and remains a global health concern. The parasite has a highly adaptable life cycle comprising successive rounds of asexual replication in a vertebrate host and sexual maturation in the ...
Samhita Das, Tanaya Unhale, Carine Marinach, Belsy del Carmen Valeriano Alegria, Camille Roux, Hélène Madry, Badreddine Mohand Oumoussa, Rogerio Amino, Shiroh Iwanaga, Sylvie Briquet, Olivier Silvie   +10 more
doaj   +2 more sources

Taurine potentiates artemisinin efficacy against malaria by modulating the immune response in Plasmodium berghei-infected mice [PDF]

Parasites & Vectors
Background Artemisinin (ART) is a frontline drug for the treatment of malaria; however, the emergence of ART-resistant Plasmodium strains necessitates increasing ART sensitivity.
Xin Li, Ning Jiang, Qilong Li, Kexin Zheng, Yiwei Zhang, Xiaoyu Sang, Ying Feng, Ran Chen, Qijun Chen   +8 more
doaj   +2 more sources

The Effect of Azadirachta indica leaves extract on Transforming Growth Factor-β and Tumor Necrosis Factor-α in a Plasmodium berghei infected Mice model

Journal of Agromedicine and Medical Sciences (AMS), 2021
Malaria is a health problem for the world's population and is predominantly located in tropical and subtropical areas. The three countries with the most malaria cases are India (58%), followed by Indonesia (20%), then Myanmar (16%).
Zainabur Rahmah
doaj   +1 more source

Plasmodium parasite exploits host aquaporin-3 during liver stage malaria infection. [PDF]

PLoS Pathogens, 2018
Within the liver a single Plasmodium parasite transforms into thousands of blood-infective forms to cause malaria. Here, we use RNA-sequencing to identify host genes that are upregulated upon Plasmodium berghei infection of hepatocytes with the ...
Dora Posfai, Kayla Sylvester, Anupama Reddy, Jack G Ganley, Johannes Wirth, Quinlan E Cullen, Tushar Dave, Nobutaka Kato, Sandeep S Dave, Emily R Derbyshire   +9 more
doaj   +1 more source

A Plasmodium falciparum host-targeting motif functions in export during blood stage infection of the rodent malarial parasite Plasmodium berghei. [PDF]

PLoS ONE, 2008
Plasmodium falciparum (P. falciparum) secretes hundreds of proteins--including major virulence proteins--into the host erythrocyte. In order to reach the host cytoplasm, most P. falciparum proteins contain an N terminal host-targeting (HT) motif composed
Julia J MacKenzie, Noé D Gómez, Souvik Bhattacharjee, Shaina Mann, Kasturi Haldar   +4 more
doaj   +1 more source