Results 21 to 30 of about 18,594 (231)

Effects of Moringa oleifera Extract as an Immunomodulator of Lymphocyte Cells and Macrophages in BALB/c Mice Infected with Plasmodium berghei

Folia Medica Indonesiana, 2023
Highlights: 1. This study assessed the immunomodulatory potential of Moringa oleifera, which may serve as a natural source for antimalarial treatment. 2.
Putu Khrisna Dharma Jaya, Putu Indah Budi Apsari, Pande Made Alitta Cantika Putri Nadya Dewi, Dewa Ayu Agus Sri Laksemi, I Ketut Cahyadi Adi Winata Sutarta   +4 more
doaj   +1 more source

Morphogenesis of Plasmodium zoites is uncoupled from tensile strength. [PDF]

, 2013
A shared feature of the motile stages (zoites) of malaria parasites is a cortical cytoskeletal structure termed subpellicular network (SPN), thought to define and maintain cell shape.
Tremp, Annie Z, Dessens, Johannes T, Carter, Victoria, Saeed, Sadia   +3 more
core   +1 more source

Structural basis of malaria transmission blockade by a monoclonal antibody to gamete fusogen HAP2

eLife, 2021
HAP2 is a transmembrane gamete fusogen found in multiple eukaryotic kingdoms and is structurally homologous to viral class II fusogens. Studies in Plasmodium have suggested that HAP2 is an attractive target for vaccines that block transmission of malaria.
Juan Feng, Xianchi Dong, Adam DeCosta, Yang Su, Fiona Angrisano, Katarzyna A Sala, Andrew M Blagborough, Chafen Lu, Timothy A Springer   +8 more
doaj   +1 more source

The role of cGMP signalling in regulating life cycle progression of Plasmodium. [PDF]

, 2012
The 3'-5'-cyclic guanosine monophosphate (cGMP)-dependent protein kinase (PKG) is the main mediator of cGMP signalling in the malaria parasite. This article reviews the role of PKG in Plasmodium falciparum during gametogenesis and blood stage schizont ...
Baker, David A, Bowyer, Paul W, Hopp, Christine S   +2 more
core   +1 more source

Universal features of post-transcriptional gene regulation are critical for Plasmodium zygote development [PDF]

, 2010
A universal feature of metazoan sexual development is the generation of oocyte P granules that withhold certain mRNA species from translation to provide coding potential for proteins during early post-fertilization development.
Lasonder Edwin, Franke-Fayard, Blandine M. D., Edwin Lasonder, Carret Céline K., Waters Andrew P., Lasonder, Edwin, Gunnar R Mair, Franke-Fayard Blandine M. D., Roeland W Dirks, Waters, A.P., Wiegant, J.C., Céline K Carret, Mair, G.R., Dimopoulos George, Lindsey S Garver, Mair Gunnar R., Wiegant, G., Janse, Chris J., Franke-Fayard, B.M.D., Carret, C.K., Dirks Roeland W., Mair, Gunnar R., Blandine M D Franke-Fayard, Dimopoulos, George, Wiegant, J.C.A.G., Lasonder, E., Dimopoulos, G., Janse, C.J., Joop, C.A., Wiegant, Joop C. A. G., Carret, Céline K., Waters, A., George Dimopoulos, Dirks, Roeland W., Waters, Andrew P., Garver, Lindsey S., Janse Chris J., Chris J Janse, Garver Lindsey S., Joop C A G Wiegant, Garver, L.S., Wiegant Joop C. A. G., Dirks, R.W., Franke-Fayard, B., Andrew P Waters   +44 more
core   +1 more source

Plasmodium berghei K13 Mutations Mediate In Vivo Artemisinin Resistance That Is Reversed by Proteasome Inhibition

mBio, 2020
The recent emergence of Plasmodium falciparum parasite resistance to the first line antimalarial drug artemisinin is of particular concern. Artemisinin resistance is primarily driven by mutations in the P.
Nelson V. Simwela, Barbara H. Stokes, Dana Aghabi, Matt Bogyo, David A. Fidock, Andrew P. Waters   +5 more
doaj   +1 more source

Altered Lipid Composition of Surfactant and Lung Tissue in Murine Experimental Malaria-Associated Acute Respiratory Distress Syndrome. [PDF]

PLoS ONE, 2015
Malaria-associated acute lung injury (MA-ALI) and its more severe form malaria-associated acute respiratory distress syndrome (MA-ARDS) are common, often fatal complications of severe malaria infections. However, little is known about their pathogenesis.
Diletta Scaccabarozzi, Katrien Deroost, Natacha Lays, Fausta Omodeo Salè, Philippe E Van den Steen, Donatella Taramelli   +5 more
doaj   +1 more source

Functional characterization of the Plasmodium falciparum and P-berghei homologues of macrophage migration inhibitory factor [PDF]

, 2007
Macrophage migration inhibitory factor (MIF) is a mammalian cytokine that participates in innate and adaptive immune responses. Homologues of mammalian MIF have been discovered in parasite species infecting mammalian hosts (nematodes and malaria ...
Sarah E. Reece, Pain, Arnab, Robert Kleemann, Kooistra, Teake, Augustijn, Kevin D., Reece, Sarah E., Thompson, Joanne, Siebum, Arjan H. G., Joanne Thompson, Kevin D. Augustijn, Waters, Andrew P., Arjan H. G. Siebum, Kleemann, Robert, Arnab Pain, Janse, Chris J., Chris J. Janse, Teake Kooistra, Carina E. Crawford, Crawford, Carina E., Andrew P Waters   +19 more
core   +1 more source

EFEKTIVITAS PEMBERIAN NANOPARTIKEL EKSTRAK DAUN JUWET (Syzygium cumini) SEBAGAI ADJUVANT TERAPI TERHADAP GAMBARANHISTOPATOLOGI PULMO MENCIT (Mus musculus) YANG DIINFEKSI Plasmodium bhergei

Journal of Basic Medical Veterinary, 2020
The purpose of this study was to learn how to use juwet nanoparticle leaf extract (Syzygium cumini) as an adjunct therapy in pulmonary histopathological mice (Mus musculus) supported by Plasmodium berghei.
Zerlinda Dyah Ayu, Lilik Maslachah, Koesnoto Supranianondo, Endang Suprihati, Hani Plumeriastuti, Rahmi Sugihartuti   +5 more
doaj   +1 more source

Life cycle studies of the hexose transporter of Plasmodiumspecies and genetic validation of their essentiality [PDF]

, 2010
A Plasmodium falciparum hexose transporter (PfHT) has previously been shown to be a facilitative glucose and fructose transporter. Its expression in Xenopus laevis oocytes and the use of a glucose analogue inhibitor permitted chemical validation of PfHT ...
Tewari, R, Tewari, Rita, Tewari, R., Doerig, Christian, Morin, C, Slavic, K., Straschil, U., Straschil, U, Krishna, S., Doerig, C., Krishna, S, Straschil, Ursula, Krishna, Sanjeev, Slavic, K, Reininger, Luc, Morin, C., Reininger, L, Morin, Christophe, Doerig, C, Reininger, L., Slavic, Ksenija   +20 more
core   +1 more source