Results 21 to 30 of about 28,420 (218)

Plasmodium Condensin Core Subunits SMC2/SMC4 Mediate Atypical Mitosis and Are Essential for Parasite Proliferation and Transmission [PDF]

, 2020
Condensin is a multi-subunit protein complex regulating chromosome condensation and segregation during cell division. In Plasmodium spp., the causative agent of malaria, cell division is atypical and the role of condensin is unclear.
Abel, Steven, Batugedara, Gayani, Bottrill, Andrew R., Boucher, Matthew, Brady, Declan, Daniel, Emilie, Freville, Aline, Gupta, Dinesh, Holder, Anthony A., Hollin, Thomas, Le Roch, Karine G., Lu, Xueqing Maggie, Pandey, Rajan, Rea, Edward, Stanway, Rebecca R., Tewari, Rita, Wall, Richard J., Wheatley, Sally, Zeeshan, Mohammad   +18 more
core   +3 more sources

Using green fluorescent malaria parasites to screen for permissive vector mosquitoes

Malaria Journal, 2006
Background The Plasmodium species that infect rodents, particularly Plasmodium berghei and Plasmodium yoelii, are useful to investigate host-parasite interactions. The mosquito species that act as vectors of human plasmodia in South East Asia, Africa and
Martin Beatrice, Frischknecht Friedrich, Thiery Isabelle, Bourgouin Catherine, Menard Robert   +4 more
doaj   +1 more source

Ecology of asynchronous asexual replication: the intraerythrocytic development cycle of Plasmodium berghei is resistant to host rhythms

Malaria Journal, 2021
Background Daily periodicity in the diverse activities of parasites occurs across a broad taxonomic range. The rhythms exhibited by parasites are thought to be adaptations that allow parasites to cope with, or exploit, the consequences of host activities
Aidan J. O’Donnell, Sarah E. Reece
doaj   +1 more source

Copper-transporting ATPase is important for malaria parasite fertility [PDF]

, 2013
Homeostasis of the trace element copper is essential to all eukaryotic life. Copper serves as a cofactor in metalloenzymes and catalyses electron transfer reactions as well as the generation of potentially toxic reactive oxygen species. Here, we describe
Kenthirapalan, Sanketha, Kooij, Taco W. A., Matuschewski, Kai, Waters, Andrew P.   +3 more
core   +2 more sources

Effects of Raw Ethanolic Seed Extract of Tetracarpidium conophorum on Heamatological and Histopathological Parameters in Swiss Albino Mice Infected with Plasmodium berghei [PDF]

, 2017
Study was carried out to determine the heamatological and histopathological effects of raw ethanolic seed extract of Tetracarpidium conophorum in swiss albino mice infected with Plasmodium berghei (NK65).
D. A. Oloruntola, E. O. Dada, I. B. Osho, O. O. Ogundolie   +3 more
core   +1 more source

Amodiaquine resistance in Plasmodium berghei is associated with PbCRT His95Pro mutation, loss of chloroquine, artemisinin and primaquine sensitivity, and high transcript levels of key transporters [version 2; referees: 2 approved, 1 approved with reservations]

Wellcome Open Research, 2018
Background: The human malaria parasite Plasmodium falciparum has evolved drug evasion mechanisms to all available antimalarials. The combination of amodiaquine-artesunate is among the drug of choice for treatment of uncomplicated malaria.
Loise Ndung'u, Benard Langat, Esther Magiri, Joseph Ng'ang'a, Beatrice Irungu, Alexis Nzila, Daniel Kiboi   +6 more
doaj   +1 more source

Effects of Moringa oleifera Extract as an Immunomodulator of Lymphocyte Cells and Macrophages in BALB/c Mice Infected with Plasmodium berghei

Folia Medica Indonesiana, 2023
Highlights: 1. This study assessed the immunomodulatory potential of Moringa oleifera, which may serve as a natural source for antimalarial treatment. 2.
Putu Khrisna Dharma Jaya, Putu Indah Budi Apsari, Pande Made Alitta Cantika Putri Nadya Dewi, Dewa Ayu Agus Sri Laksemi, I Ketut Cahyadi Adi Winata Sutarta   +4 more
doaj   +1 more source

Microstructured blood vessel surrogates reveal structural tropism of motile malaria parasites [PDF]

, 2017
Plasmodium sporozoites, the highly motile forms of the malaria parasite, are transmitted naturally by mosquitoes and traverse the skin to find, associate with, and enter blood capillaries.
Battista, Anna, Dahan, Noa, Fackler, Oliver T., Frischknecht, Friedrich, Haraszti, Tamas, Hellmann, Janina K., Lemgruber, Leandro, Muthinja, Mendi J., Ripp, Johanna, Schwarz, Ulrich S., Schütz, Lucas, Spatz, Joachim P.   +11 more
core   +1 more source

Structural basis of malaria transmission blockade by a monoclonal antibody to gamete fusogen HAP2

eLife, 2021
HAP2 is a transmembrane gamete fusogen found in multiple eukaryotic kingdoms and is structurally homologous to viral class II fusogens. Studies in Plasmodium have suggested that HAP2 is an attractive target for vaccines that block transmission of malaria.
Juan Feng, Xianchi Dong, Adam DeCosta, Yang Su, Fiona Angrisano, Katarzyna A Sala, Andrew M Blagborough, Chafen Lu, Timothy A Springer   +8 more
doaj   +1 more source

Review of pyronaridine anti-malarial properties and product characteristics. [PDF]

, 2012
Pyronaridine was synthesized in 1970 at the Institute of Chinese Parasitic Disease and has been used in China for over 30 years for the treatment of malaria.
Arbe-Barnes, Sarah J, Borghini-Fuhrer, Isabelle, Craft, J Carl, Croft, Simon L, Duparc, Stephan, Fleckenstein, Lawrence, Rim, Han-Jong, Shin, Chang-Sik   +7 more
core   +2 more sources