Results 31 to 40 of about 28,420 (218)

Studying the effect of chloroquine on sporozoite-induced protection and immune responses in Plasmodium berghei malaria [PDF]

, 2015
BACKGROUND Sporozoite immunization of animals and humans under a chemo-prophylactic cover of chloroquine (CPS-CQ) efficiently induces sterile protection against malaria.
Bijker, Else M, Cockburn, Ian, Nganou-Makamdop, Krystelle, Sauerwein, Robert W, van Gemert, Geert-Jan, Zavala, Fidel   +5 more
core   +2 more sources

EFEKTIVITAS PEMBERIAN NANOPARTIKEL EKSTRAK DAUN JUWET (Syzygium cumini) SEBAGAI ADJUVANT TERAPI TERHADAP GAMBARANHISTOPATOLOGI PULMO MENCIT (Mus musculus) YANG DIINFEKSI Plasmodium bhergei

Journal of Basic Medical Veterinary, 2020
The purpose of this study was to learn how to use juwet nanoparticle leaf extract (Syzygium cumini) as an adjunct therapy in pulmonary histopathological mice (Mus musculus) supported by Plasmodium berghei.
Zerlinda Dyah Ayu, Lilik Maslachah, Koesnoto Supranianondo, Endang Suprihati, Hani Plumeriastuti, Rahmi Sugihartuti   +5 more
doaj   +1 more source

Altered Lipid Composition of Surfactant and Lung Tissue in Murine Experimental Malaria-Associated Acute Respiratory Distress Syndrome. [PDF]

PLoS ONE, 2015
Malaria-associated acute lung injury (MA-ALI) and its more severe form malaria-associated acute respiratory distress syndrome (MA-ARDS) are common, often fatal complications of severe malaria infections. However, little is known about their pathogenesis.
Diletta Scaccabarozzi, Katrien Deroost, Natacha Lays, Fausta Omodeo Salè, Philippe E Van den Steen, Donatella Taramelli   +5 more
doaj   +1 more source

Arylmethylamino steroids as antiparasitic agents [PDF]

, 2017
In search of antiparasitic agents, we here identify arylmethylamino steroids as potent compounds and characterize more than 60 derivatives. The lead compound 1o is fast acting and highly active against intraerythrocytic stages of chloroquine-sensitive ...
Becker, Katja, Beckmann, Svenja, Blandin, Stéphanie, Brakhage, Axel, Burrows, Jeremy, Dahse, Hans-Martin, Davioud-Charvet, Elisabeth, Elhabiri, Mourad, Goetz, Alice-Anne, Grevelding, Christoph G., Jortzik, Esther, Krieg, Reimar, Nuryyeva, Selbi, Pinkerton, Anthony B., Quack, Thomas, Rahbari, Mahsa, Rahlfs, Stefan, Schönecker, Bruno, Voigt, Kerstin, Wittlin, Sergio   +19 more
core   +3 more sources

Plasmodium berghei K13 Mutations Mediate In Vivo Artemisinin Resistance That Is Reversed by Proteasome Inhibition

mBio, 2020
The recent emergence of Plasmodium falciparum parasite resistance to the first line antimalarial drug artemisinin is of particular concern. Artemisinin resistance is primarily driven by mutations in the P.
Nelson V. Simwela, Barbara H. Stokes, Dana Aghabi, Matt Bogyo, David A. Fidock, Andrew P. Waters   +5 more
doaj   +1 more source

Suppression of experimental cerebral malaria by disruption of malate:quinone oxidoreductase

Malaria Journal, 2017
Background Aspartate, which is converted from oxaloacetate (OAA) by aspartate aminotransferase, is considered an important precursor for purine salvage and pyrimidine de novo biosynthesis, and is thus indispensable for the growth of Plasmodium parasites ...
Mamoru Niikura, Keisuke Komatsuya, Shin-Ichi Inoue, Risa Matsuda, Hiroko Asahi, Daniel Ken Inaoka, Kiyoshi Kita, Fumie Kobayashi   +7 more
doaj   +1 more source

A member of the tryptophan-rich protein family is required for efficient sequestration of Plasmodium berghei schizonts.

PLoS Pathogens, 2022
Protein export and host membrane remodeling are crucial for multiple Plasmodium species to establish a niche in infected hosts. To better understand the contribution of these processes to successful parasite infection in vivo, we sought to find and ...
Julie-Anne Gabelich, Josephine Grützke, Florian Kirscht, Oliver Popp, Joachim M Matz, Gunnar Dittmar, Melanie Rug, Alyssa Ingmundson   +7 more
doaj   +1 more source

Uji Aktivitas Antimalaria dari Spons Xestospongia sp. Asal Pulau Yapen secara In Vivo

Jurnal Kelautan Tropis, 2021
It is generally admitted that marine sponge has rich of secondary metabolite as alkaloids, peptides and terpene. Those various compounds can be used for antimalarial drug.  This study aims to evaluate the in vivo antimalarial activity and to characterize
Murtihapsari Murtihapsari, Mathelda K. Roreng, Apriani Parubak, Alif Rahman   +3 more
doaj   +1 more source

Rocaglates as dual-targeting agents for experimental cerebral malaria [PDF]

, 2018
Cerebral malaria (CM) is a severe and rapidly progressing complication of infection by Plasmodium parasites that is associated with high rates of mortality and morbidity.
Ayi, Kodjo, Brown, Lauren E., Cencic, Regina, Crandall, Ian, Gros, Philippe, Kain, Kevin C., Kennedy, James M., Langlais, David, Moradin, Neda, Pelletier, Jerry, Porco, John A., Schmeing, Martin, Tarry, Michael J.   +12 more
core   +1 more source

Extract of Morinda lucida leaf rescues hypoglycaemic and dyslipidaemic conditions in Plasmodium berghei-infected mice [PDF]

Bulletin of Natural Sciences Research, 2022
Increasing drug resistance is a great threat to malaria control. Therefore, a continuous investigation into alternative therapy to mitigate malaria-associated damages is important.
Abdulkareem Adam Olaitan, Babamale Abdulkareem Olarewaju, Anifowoshe Abass Toba, Opeyemi Olufunke Adenike Opeyemi Olufunke Adenike, Oloriegbe Nusirat, Adamolekun Comfort, Adetula Samson, Ala Adeola Adefoluke   +7 more
doaj   +1 more source