Results 51 to 60 of about 90,646 (224)

Cortisone and Plasmodium berghei Infection in Mice [PDF]

Nature, 1952
THERE is considerable clinical evidence to show that in persons infected with malaria various stimuli may precipitate an acute attack. These stimuli include surgical operations, the injection of vaccines, exposure to cold, and possibly, for persons who have not become acclimatized, ascent to high altitudes.
G M, FINDLAY, E M, HOWARD
openaire   +2 more sources

Transgenic selection and underlying mechanisms in apicomplexan parasites

The FEBS Journal, EarlyView.
Transgenic selection markers have driven genetic engineering in apicomplexans, enabling precise, iterative experiments. This review discusses mechanistic details of drug selection markers, strategies for marker recycling, and practical considerations for several clinically relevant parasites.
Swaroop Peddiraju, Rakhee Lohia, Nishith Gupta   +2 more
wiley   +1 more source

A new role for an old antimicrobial: lysozyme c-1 can function to protect malaria parasites in Anopheles mosquitoes. [PDF]

PLoS ONE, 2011
Plasmodium requires an obligatory life stage in its mosquito host. The parasites encounter a number of insults while journeying through this host and have developed mechanisms to avoid host defenses.
Mayur K Kajla, Lei Shi, Bin Li, Shirley Luckhart, Jianyong Li, Susan M Paskewitz   +5 more
doaj   +1 more source

A Genetically Encoded Marker for Imaging of Internal Plasmodium Membranes

Molecular Microbiology, EarlyView.
IMMP is a peptide‐based marker that labels internal membranes across multiple stages and species of the malaria‐causing parasite Plasmodium. It works in both live and fixed samples and supports long‐term live‐cell imaging. ABSTRACT Fluorescence microscopy is a powerful tool to analyze the subcellular architecture, and long‐term live‐cell imaging ...
Leah Zink, Viola Reuschenbach, Samy Sid Ahmed, Muriel Lauer, Jana Niethammer, Aistė Kudulytė, Katharina Zorko, Oliver T. Fackler, Franziska Hentzschel, Markus Ganter   +9 more
wiley   +1 more source

Characterization of Sec14 Domain–Containing Proteins in the Malaria Parasite Plasmodium falciparum

Molecular Microbiology, EarlyView.
During asexual blood‐stage development, P. falciparum Sec14 proteins display distinct localizations suggesting specialized roles in lipid exchange. PfSec14‐1 initially localizes to the nucleus before moving to the ER and Golgi alongside PfSec14‐4 during schizogony.
Florian Lauruol, Dominik Šťastný, J. Pedro Fernandez‐Murray, Christopher R. McMaster, Peter Griač, Dave Richard   +5 more
wiley   +1 more source

Expression profiling of Plasmodium berghei HSP70 genes for generation of bright red fluorescent parasites.

PLoS ONE, 2013
Live cell imaging of recombinant malarial parasites encoding fluorescent probes provides critical insights into parasite-host interactions and life cycle progression.
Marion Hliscs, Carolin Nahar, Friedrich Frischknecht, Kai Matuschewski   +3 more
doaj   +1 more source

CRISPR/Cas9-Based Knockout of GNAQ Reveals Differences in Host Cell Signaling Necessary for Egress of Apicomplexan Parasites

mSphere, 2020
Toxoplasma gondii and members of the genus Plasmodium are obligate intracellular parasites that leave their infected host cell upon a tightly controlled process of egress. Intracellular replication of the parasites occurs within a parasitophorous vacuole,
Paul-Christian Burda, Hugo Bisio, Jean-Baptiste Marq, Dominique Soldati-Favre, Volker T. Heussler   +4 more
doaj   +1 more source

Plasmodium Actin‐Like Proteins 3 and 5a Are Required for Subsequent Steps of Mosquito Infection

Molecular Microbiology, EarlyView.
Actin‐like proteins (Alps) are highly conserved, apicomplexan‐specific members of the actin superfamily. Using reverse genetics, we have identified that Alp3 and Alp5a are required at separate steps of transmission of the malaria parasite to its mosquito host.
Caroline Busse, Yukino Kobayashi, Andrea Diers, Annika M. Binder, Friedrich Frischknecht, Ross G. Douglas   +5 more
wiley   +1 more source

Proteomic analysis of the Plasmodium male gamete reveals the key role for glycolysis in flagellar motility. [PDF]

, 2014
BACKGROUND: Gametogenesis and fertilization play crucial roles in malaria transmission. While male gametes are thought to be amongst the simplest eukaryotic cells and are proven targets of transmission blocking immunity, little is known about their ...
Mara Lawniczak, Wass, Mark N., Arthur M Talman, Sinden, Robert E., Prieto, Judith H, Yates, JR, Talman, Arthur M, Sinden, Robert, Michael JE Sternberg, Sinden, Robert E, Stanway, RS, Graham, David R, Marques, S, Ubaida-Mohien, Ceereena, Tao Xu, Marques, Sara, Ecker, A, Sternberg, MJ, Sternberg, Michael J E, Yates, John R., III, Prieto, JH, Talman, AM, Rhoel R Dinglasan, Xu, T, Ubaida-Mohien, C, Sanjeev Krishna, Lawniczak, Mara, Wass, MN, Wass, Mark N, Dinglasan, Rhoel R, Robert E Sinden, Talman, Arthur M., Christophides, Georges K., Christophides, Georges K, Andrea Ecker, Sara Marques, Ceereena Ubaida-Mohien, Sternberg, Michael JE, Limenitakis Stanway, Rebecca, Dinglasan, Rhoel R., Georges K Christophides, Sternberg, MJE, Yates, John R, Roland Frank, Stanway, Rebecca S., Graham, David R., Xu, Tao, Frank, Roland, Prieto, Judith H., Rebecca S Stanway, Dinglasan, RR, John R Yates, Sternberg, Michael J. E., Stanway, Rebecca S, Graham, DR, Krishna, S, Mark N Wass, Christophides, GK, Lawniczak, M, Sinden, RE, Frank, R, Krishna, Sanjeev, Ecker, Andrea, David R Graham, Judith H Prieto   +64 more
core   +2 more sources

Peptide‐Enabled Nanoplatforms for Malaria and Leishmaniasis: From Intracellular Targeting to Translational Diagnostic Perspectives

ChemMedChem, Volume 21, Issue 18, 28 September 2026.
Peptide‐enabled nanoplatforms offer multifunctional strategies for the treatment and diagnosis of malaria and leishmaniasis. Liposomal, polymeric, and metallic nanocarriers, together with cell‐penetrating peptides and parasite‐derived mimotopes, can improve targeted drug delivery, stability, bioavailability, and intracellular localization.
Christian S. Carnero Canales, Ana Clara Lunardi Yagi, Túlio Custódio Reis, Jessica Ingrid Cazorla, Jade Rojas Villar, Marcia A. Graminha, Roxana Yesenia Pastrana Alta, Fernando Rogério Pavan   +7 more
wiley   +1 more source