Results 51 to 60 of about 18,594 (231)

Discovery of an Atypical Arp2/3 Complex in Malaria Parasites Sheds New Light on Nuclear Actin

Cytoskeleton, EarlyView.
ABSTRACT The Arp2/3 complex is a key actin nucleator essential for cytoskeletal dynamics in eukaryotes. Previously believed absent in apicomplexan parasites, we recently identified an atypical Arp2/3 complex in malaria parasites consisting of five divergent subunits and a putative kinetochore‐associated factor.
Franziska Hentzschel, Friedrich Frischknecht, Matthias Marti   +2 more
wiley   +1 more source

The Plasmodium berghei Ca(2+)/H(+) exchanger, PbCAX, is essential for tolerance to environmental Ca(2+) during sexual development.

, 2013
Ca(2+) contributes to a myriad of important cellular processes in all organisms, including the apicomplexans, Plasmodium and Toxoplasma. Due to its varied and essential roles, free Ca(2+) is tightly regulated by complex mechanisms.
Staines, Henry M., David S Guttery, Wheatley Sally P., Guttery, DS, Dominique Soldati-Favre (79026), Leon R. McFarlane (7795319), Sally P. Wheatley (7750238), Soldati-Favre, D, Pittman, Jon K, Tewari Rita, Jon K Pittman, Sally P. Wheatley (384069), Wheatley, Sally P., Frénal, K, Sanjeev Krishna (4917), Leon R McFarlane, Benoit Poulin (134241), Wheatley, SP, Frénal Karine, Dominique Soldati-Favre, Ksenija Slavic (384068), Karine Frénal, Staines, Henry M, Sanjeev Krishna, Guttery, David S, Poulin, Benoit, Frénal, Karine, McFarlane, Leon R, Rita Tewari, Karine Frénal (384066), Ksenija Slavic, Guttery, David S., Tewari, R, Tewari, Rita, Poulin Benoit, Pittman Jon K., Pittman, JK, Poulin, B, Rita Tewari (134257), Henry M Staines, Henry M. Staines (7795322), McFarlane, Leon R., Krishna Sanjeev, Soldati-Favre Dominique, Pittman, Jon K.; id_orcid, Slavic, Ksenija, McFarlane Leon R., Staines Henry M., McFarlane, LR, Jon K. Pittman (127550), Guttery David S., Staines, HM, Krishna, S, Slavic Ksenija, Krishna, Sanjeev, Slavic, K, David S. Guttery (134240), Sally P Wheatley, Leon R. McFarlane (384067), Henry M. Staines (384070), David S. Guttery (7629998), Soldati-Favre, Dominique, Benoit Poulin, Wheatley, Sally P   +63 more
core   +1 more source

The Plasmodium eukaryotic initiation factor-2α kinase IK2 controls the latency of sporozoites in the mosquito salivary glands [PDF]

, 2010
Sporozoites, the invasive form of malaria parasites transmitted by mosquitoes, are quiescent while in the insect salivary glands. Sporozoites only differentiate inside of the hepatocytes of the mammalian host. We show that sporozoite latency is an active
Sullivan, W. J., Sullivan, William J., Sakthivel, Ramanavelan, Fontoura, Beatriz M. A., Doerig, C., Winzeler, Elizabeth A., Tuteja, R., Roos, David S., Gueirard, Pascale, Ruth S. Nussenzweig, Tuteja, Renu, Anat Caspi, Robert Ménard, Meister, S., Ranford-Cartwright, L., Ranford-Cartwright, Lisa, Lisa Ranford-Cartwright, Nussenzweig, Victor, Ramanavelan Sakthivel, Nussenzweig, V., Ranford-Cartwright, L.C., Clare Fennell, Min Zhang, Sakthivel, R., Fennell, Clare, Nussenzweig, R. S., Sullivan, William J., Jr., Caspi, A., Beatriz M.A. Fontoura, Gueirard, P., Renu Tuteja, Menard, R., William J. Sullivan, Pascale Gueirard, Ménard, Robert, Meister, Stephan, Stephan Meister, Victor Nussenzweig, Doerig, Christian, Fontoura, B. M. A., David S. Roos, Zhang, Min, Roos, D. S., Christian Doerig, Fennell, C., Winzeler, E. A., Caspi, Anat, Zhang, M., Elizabeth A. Winzeler, Nussenzweig, Ruth S.   +49 more
core   +1 more source

Quantitative electroencephalographic measures during postmalarial epileptogenesis

Epilepsia, EarlyView.
Abstract Objective Severe malaria with neurologic involvement contributes significantly to the global burden of acquired pediatric epilepsy. We studied quantitative electroencephalographic (EEG) measures in postmalarial epileptogenesis. Methods A total of 186 patients, aged 6 months to 11 years, with confirmed central nervous system malaria were ...
Rasesh B. Joshi, Suzanna Mwanza, Hitten P. Zaveri, Joseph Kasolo, Angela Masempela, Thelma Musakanya, Tina Mwale, Violet Nambeye, Rosemary Nyriongo, Ruth A. Tembo, Christopher Cortina, Bo Zhang, Gretchen L. Birbeck, Alexander Rotenberg, Archana A. Patel   +14 more
wiley   +1 more source

Distinct temporal recruitment of Plasmodium alveolins to the subpellicular network. [PDF]

, 2014
The zoite stages of malaria parasites (merozoite, ookinete and sporozoite) possess a distinctive cortical structure termed the pellicle, which is defined by a double membrane layer named the inner membrane complex (IMC).
Tremp, Annie Z, Al-Khattaf, Fatimah S, Dessens, Johannes T, Fatimah S. Al-khattaf, Annie Z. Tremp, Johannes T. Dessens   +5 more
core   +1 more source

Expression profiling of Plasmodium berghei HSP70 genes for generation of bright red fluorescent parasites.

PLoS ONE, 2013
Live cell imaging of recombinant malarial parasites encoding fluorescent probes provides critical insights into parasite-host interactions and life cycle progression.
Marion Hliscs, Carolin Nahar, Friedrich Frischknecht, Kai Matuschewski   +3 more
doaj   +1 more source

CRISPR/Cas9-Based Knockout of GNAQ Reveals Differences in Host Cell Signaling Necessary for Egress of Apicomplexan Parasites

mSphere, 2020
Toxoplasma gondii and members of the genus Plasmodium are obligate intracellular parasites that leave their infected host cell upon a tightly controlled process of egress. Intracellular replication of the parasites occurs within a parasitophorous vacuole,
Paul-Christian Burda, Hugo Bisio, Jean-Baptiste Marq, Dominique Soldati-Favre, Volker T. Heussler   +4 more
doaj   +1 more source

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

Gene-specific signatures of elevated non-synonymous substitution rates correlate poorly across the Plasmodium genus. [PDF]

, 2008
BACKGROUND: Comparative genome analyses of parasites allow large scale investigation of selective pressures shaping their evolution. An acute limitation to such analysis of Plasmodium falciparum is that there is only very partial low-coverage genome ...
David J Conway, Polley Spencer D., Conway, David J, Gareth D Weedall, Conway David J., Weedall, Gareth D, Spencer D Polley, Spencer D. Polley, Weedall Gareth D., Polley, Spencer D, Gareth D. Weedall, David J. Conway   +11 more
core   +1 more source

Spatiotemporal and functional characterisation of the Plasmodium falciparum cGMP-dependent protein kinase. [PDF]

, 2012
Signalling by 3'-5'-cyclic guanosine monophosphate (cGMP) exists in virtually all eukaryotes. In the apicomplexan parasite Plasmodium, the cGMP-dependent protein kinase (PKG) has previously been reported to play a critical role in four key stages of the ...
Baker, David A, Lev Solyakov (122244), Solyakov, Lev, David A Baker, Flueck, Christian, Lev Solyakov, L. Solyakov (7638338), Hopp Christine S., Flueck Christian, Andrew Tobin (122248), David A. Baker (122252), Christine S Hopp, David A. Baker, D. A. Baker (7638335), A. B. Tobin (7638326), Solyakov Lev, C. Flueck (7638332), Andrew Tobin, Christine S. Hopp (122239), Baker David A., Tobin Andrew, Christian Flueck, C. S. Hopp (7638329), Tobin, Andrew, Christian Flueck (122240), Hopp, Christine S   +25 more
core   +1 more source