Fighting Plasmodium chloroquine resistance with acetylenic chloroquine analogues [PDF]
International Journal for Parasitology: Drugs and Drug Resistance, 2022 Malaria is among the tropical diseases that cause the most deaths in Africa. Around 500,000 malaria deaths are reported yearly among African children under the age of five.
Wilian A. Cortopassi +14 more
doaj +6 more sources
A Rapid and Specific Genotyping Platform for Plasmodium falciparum Chloroquine Resistance via Allele-Specific PCR with a Lateral Flow Assay [PDF]
Microbiology Spectrum, 2022 Single-nucleotide polymorphisms and genotyping related to genetic detection are several of the focuses of contemporary biotechnology development. Traditional methods are complex, take a long time, and rely on expensive instruments. Therefore, there is an
Weijia Cheng +5 more
doaj +2 more sources
International Journal for Parasitology: Drugs and Drug Resistance, 2017 Chloroquine (CQ) is highly effective against P. vivax, due to the rapid spread of CQ resistance in P. falciparum parasites; it is no longer the drug of choice against P. falciparum. This study elucidates the scenario of chloroquine efficacy at times that
Sabyasachi Das +6 more
doaj +3 more sources
Variation of the Chloroquine Resistance Transporter (Crt) Gene in Chloroquine-Resistant and Chloroquine-Sensitive Plasmodium berghei [PDF]
Iranian Journal of Parasitology, 2008 Background: The emergence and spread of chloroquine resistant Plasmodium falciparum in the world stimulated some investigators to consider different aspects of chloroquine resistance in human and rodent Plasmodia.
N Ghobakhloo +5 more
doaj +2 more sources
No Plasmodium falciparum Chloroquine Resistance Transporter and Artemisinin Resistance Mutations, Haiti [PDF]
Emerging Infectious Diseases, 2018 We obtained 78 human blood samples from areas in Haiti with high transmission of malaria and found no drug resistance–associated mutations in Plasmodium falciparum chloroquine resistance transporter and Kelch 13 genes.
Jeanne P. Vincent +4 more
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Impact of Chloroquine Resistance on Malaria Mortality
Comptes Rendus De L'Académie Des Sciences Série 3, Sciences De La Vie, 1998 Over 12 years, from 1984 to 1995, we conducted a prospective study of overall and malaria specific mortality among three rural populations in the Sahel, savanna and forest areas of Senegal. The emergence of chloroquine resistance has been associated with a dramatic increase in malaria mortality in each of the studied populations. After the emergence of
Gilles Pison +2 more
exaly +5 more sources
False Chloroquine Resistance in Africa
Lancet, The, 1997 Leonardo K Basco +2 more
exaly +4 more sources
Chloroquine‐Resistant Malaria [PDF]
The Journal of Infectious Diseases, 2001 The development of chloroquine as an antimalarial drug and the subsequent evolution of drug-resistant Plasmodium strains had major impacts on global public health in the 20th century. In P. falciparum, the cause of the most lethal human malaria, chloroquine resistance is linked to multiple mutations in PfCRT, a protein that likely functions as a ...
T E, Wellems, C V, Plowe
openaire +2 more sources
Simple Molecular Methods for Early Detection of Chloroquine Drug Resistance in Plasmodium vivax and Plasmodium falciparum [PDF]
Journal of Clinical and Diagnostic Research, 2016 Introduction: Malaria is a human disease of which causes high morbidity and mortality. In Plasmodium falciparum malaria, the resistance to antimalarial drugs, especially chloroquine (CQ) is one of the paramount factors contributing to the global ...
Gurjeet Singh +2 more
doaj +1 more source
Lack of Evidence for Chloroquine-Resistant Plasmodium falciparum Malaria, Leogane, Haiti
Emerging Infectious Diseases, 2012 Plasmodium falciparum malaria in Haiti is considered chloroquine susceptible, although resistance transporter alleles associated with chloroquine resistance were recently detected.
Ami Neuberger +3 more
doaj +1 more source