Results 31 to 40 of about 2,244,050 (276)

Detection of K76T Mutation in pfcrt Gene as an Applicable Ge-netic Marker for Prediction of Chloroquine Resistant falciparum Malaria in Isolates from an Endemic District of Iran [PDF]

Iranian Journal of Parasitology, 2008
Background: This study investigated the association between pfcrt, T76 allele and chloroquine resistance in patients with falciparum malaria. Molecular assays for point mutations on drugs resistance-related genes are applied tools for monitoring emerging
A Raeisi, H Keshavarz, SR Naddaf, H Uemura, H Kanbara, MR Razavi, M Assmar, M Nateghpou, AR Esmaeili Rastaghi, M Mohebali   +9 more
doaj   +2 more sources

Community effectiveness of chloroquine and traditional remedies in the treatment of young children with falciparum malaria in rural Burkina Faso [PDF]

, 2004
Mueller O, Razum O, Traore C, Kouyate B. Community effectiveness of chloroquine and traditional remedies in the treatment of young children with falciparum malaria in rural Burkina Faso. Malaria Journal.
Kouyate Bocar, Traore, Corneille, Razum, Oliver, Mueller, Olaf, Bocar Kouyate, Kouyate, Bocar, Mueller Olaf, Razum Oliver, Oliver Razum, Corneille Traore, Traore Corneille, Olaf Mueller   +11 more
core   +1 more source

Mechanistic basis for multidrug resistance and collateral drug sensitivity conferred to the malaria parasite by polymorphisms in PfMDR1 and PfCRT.

PLoS Biology, 2022
Polymorphisms in the Plasmodium falciparum multidrug resistance protein 1 (pfmdr1) gene and the Plasmodium falciparum chloroquine resistance transporter (pfcrt) gene alter the malaria parasite's susceptibility to most of the current antimalarial drugs ...
Sarah Heckmatt Shafik, Sashika Natasha Richards, Ben Corry, Rowena Elizabeth Martin   +3 more
doaj   +1 more source

Randomised trial of chloroquine/sulphadoxine-pyrimethamine in Gambian children with malaria: impact against multidrug-resistant P. falciparum. [PDF]

, 2006
OBJECTIVES: In the Gambia, the combination of chloroquine (CQ) and sulphadoxine-pyrimethamine (SP) has replaced CQ monotherapy for treatment of malaria caused by Plasmodium falciparum. We measured the efficacy of the combination CQ/SP, and the prevalence
Targett Geoffrey A. T, Sutherland Colin J, Samuel Dunyo, Jawara, Musa, Coleman, Rosalind, Alexander Neal, Mesa, Eduardo, Sutherland, Colin J, Hallett, Rachel, Rachel Hallett, Ord Rosalynn, Coleman Rosalind, Musa Jawara, Geoffrey A. T Targett, Pinder Margaret, Jawara Musa, Ord, Rosalynn, Walraven, Gijs, Sowe, Maimuna, Targett, Geoffrey AT, Eduardo Mesa, Dunyo, Samuel, Neal Alexander, Colin J Sutherland, Rosalind Coleman, Gijs Walraven, Sowe Maimuna, Walraven Gijs, Mesa Eduardo, Alexander, Neal, Margaret Pinder, Dunyo Samuel, Rosalynn Ord, Maimuna Sowe, Pinder, Margaret, Hallett Rachel   +35 more
core   +1 more source

Significant geographical differences in prevalence of mutations associated with Plasmodium falciparum and Plasmodium vivax drug resistance in two regions from Papua New Guinea [PDF]

, 2015
Drug resistance remains a major obstacle to malaria treatment and control. It can arise and spread rapidly, and vary substantially even at sub-national level.
Jonah Iga (175169), Barnadas, Céline, Zimmerman, Peter A., Timinao, Lincoln, Koepfli, Cristian, Peter Siba (112258), Sarah Javati (464175), John Reeder (3400391), Kiniboro, Benson, Ivo Mueller (46609), Senn, Nicolas, Javati, Sarah, Iga, Jonah, Malau, Elisheba, Rare, Lawrence, Mueller, Ivo, Elisheba Malau (3518690), Benson Kiniboro (191309), Lincoln Timinao (423264), CĂŠline Barnadas (3506528), Siba, Peter, Timothy Davis (268628), Harin Karunajeewa (336719), Davis, Timothy M., Leanne Robinson (175144), Reeder, John C., Nicolas Senn (137902), Peter Zimmerman (34037), Robinson, Leanne J., Siba, Peter M., Karunajeewa, Harin, Cristian Koepfli (191306), Lawrence Rare (377507)   +32 more
core   +1 more source

Long cryopreserved lab-adapted Plasmodium falciparum increases resistance to chloroquine but not its susceptibility

Life Sciences, Medicine and Biomedicine, 2020
Introduction: Plasmodium falciparum (P. falciparum) is a deadly protozoan that is accountable for malaria and chloroquine was the first-line antimalarial drug before its withdrawal and replaced by artemisinin.
Jing Yit Pua, Nurhidanatasha Abu Bakar, Nik Abdul Aziz Nik Kamarudin, Siti Zulaiha Ghazali, Khairul Mohd Fadzli Mustaffa   +4 more
doaj   +1 more source

A purine analog synergizes with chloroquine (CQ) by targeting Plasmodium falciparum Hsp90 (PfHsp90). [PDF]

PLoS ONE, 2013
Drug resistance, absence of an effective vaccine, and inadequate public health measures are major impediments to controlling Plasmodium falciparum malaria worldwide. The development of antimalarials to which resistance is less likely is paramount.
Dea Shahinas, Asongna Folefoc, Tony Taldone, Gabriela Chiosis, Ian Crandall, Dylan R Pillai   +5 more
doaj   +1 more source

Carriage of chloroquine-resistant parasites and delay of effective treatment increase the risk of severe malaria in Gambian children. [PDF]

, 2005
Two hundred thirty-four Gambian children with severe falciparum malaria who were admitted to the pediatric ward of a rural district hospital each were matched for age with a same-sex control subject presenting as an outpatient with uncomplicated ...
Bousema, T., Ord, Rosalynn, van Niekerk, Maarten, Walraven, Gijs, Osman, E., Bousema, J Teun, Meerman, Larissa, Osman, Emilia, Niekerk, M. van, Sutherland, Colin J, Hallett, Rachel, Meerman, L., Pinder, M., Walraven, G.E., Sutherland, C.J., Pinder, Margaret, Ord, R., Hallett, R.   +17 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Immunoglobulin G antibodies to merozoite surface antigens are associated with recovery from chloroquine-resistant Plasmodium falciparum in Gambian children. [PDF]

, 2006
We examined the hypothesis that recovery from uncomplicated malaria in patients carrying drug-resistant Plasmodium falciparum is a measure of acquired functional immunity and may therefore be associated with humoral responses to candidate vaccine ...
Jamila Ismaili, Holder, Anthony A, Ord, Rosalyn, Sutherland, Colin J, Hallett, Rachel, Rachel Hallett, McCall, Matthew BB, Ismaili, Jamila, Paul Milligan, Pinder, M., Colin J. Sutherland, Ismaili, J., Milligan, Paul, Milligan, P., Matthew B. B. McCall, McCall, M.B.B., Sisay-Joof, F., Holder, A.A., Anthony A. Holder, Rosalyn Ord, Margaret Pinder, Sutherland, C.J., Fatoumatta Sisay-Joof, Pinder, Margaret, Ord, R., Hallett, R., Sisay-Joof, Fatoumatta   +26 more
core   +2 more sources