Results 31 to 40 of about 2,436,233 (271)

Plasmodium vivax resistance to chloroquine in Dawei, southern Myanmar. [PDF]

, 2008
OBJECTIVE: To assess the efficacy of chloroquine in the treatment of Plasmodium vivax malaria in in Dawei District, southern Myanmar. METHODS: Enrolled patients at Sonsinphya clinic >6 months of age were assessed clinically and parasitologically every ...
Min Lwin, M, Guthmann, J P, Annerberg, A, Pittet, A, Anna Annerberg, Anne Pittet, Myo Min Lwin, Alexandre Lesage, de Radiguès, X, Mallika Imwong, Zaw, T, Imwong, M, Lindegardh, N, Xavier De Radiguès, Nosten, F, Niklas Lindegardh, Lesage, A, Jean-Paul Guthmann, Than Zaw, François Nosten   +19 more
core   +1 more source

Antimalarial therapy selection for quinolone resistance among Escherichia coli in the absence of quinolone exposure, in tropical South America. [PDF]

PLoS ONE, 2008
BackgroundBacterial resistance to antibiotics is thought to develop only in the presence of antibiotic pressure. Here we show evidence to suggest that fluoroquinolone resistance in Escherichia coli has developed in the absence of fluoroquinolone use ...
Ross J Davidson, Ian Davis, Barbara M Willey, Keyro Rizg, Shelly Bolotin, Vanessa Porter, Jane Polsky, Nick Daneman, Allison McGeer, Paul Yang, Dennis Scolnik, Roy Rowsell, Olga Imas, Michael S Silverman   +13 more
doaj   +1 more source

Community effectiveness of chloroquine and traditional remedies in the treatment of young children with falciparum malaria in rural Burkina Faso [PDF]

, 2004
Mueller O, Razum O, Traore C, Kouyate B. Community effectiveness of chloroquine and traditional remedies in the treatment of young children with falciparum malaria in rural Burkina Faso. Malaria Journal.
Kouyate Bocar, Traore, Corneille, Razum, Oliver, Mueller, Olaf, Bocar Kouyate, Kouyate, Bocar, Mueller Olaf, Razum Oliver, Oliver Razum, Corneille Traore, Traore Corneille, Olaf Mueller   +11 more
core   +1 more source

Detection of K76T Mutation in pfcrt Gene as an Applicable Ge-netic Marker for Prediction of Chloroquine Resistant falciparum Malaria in Isolates from an Endemic District of Iran [PDF]

Iranian Journal of Parasitology, 2008
Background: This study investigated the association between pfcrt, T76 allele and chloroquine resistance in patients with falciparum malaria. Molecular assays for point mutations on drugs resistance-related genes are applied tools for monitoring emerging
A Raeisi, H Keshavarz, SR Naddaf, H Uemura, H Kanbara, MR Razavi, M Assmar, M Nateghpou, AR Esmaeili Rastaghi, M Mohebali   +9 more
doaj   +2 more sources

Mechanistic basis for multidrug resistance and collateral drug sensitivity conferred to the malaria parasite by polymorphisms in PfMDR1 and PfCRT.

PLoS Biology, 2022
Polymorphisms in the Plasmodium falciparum multidrug resistance protein 1 (pfmdr1) gene and the Plasmodium falciparum chloroquine resistance transporter (pfcrt) gene alter the malaria parasite's susceptibility to most of the current antimalarial drugs ...
Sarah Heckmatt Shafik, Sashika Natasha Richards, Ben Corry, Rowena Elizabeth Martin   +3 more
doaj   +1 more source

Concurrence of Plasmodium falciparum dhfr and crt mutations in northern Ghana. [PDF]

, 2005
BACKGROUND: Both chloroquine (CQ) and sulfadoxine-pyrimethamine (SP) are failing drugs in much of sub-Saharan Africa. Previous findings suggest an association between resistance to CQ and to SP in vivo, in vitro, and on the molecular level.
Bousema J Teun, Sauerwein, Robert W, Teunis A Eggelte, Bienzle Ulrich, Bousema, J Teun, Ehrhardt, Stephan, Eggelte Teunis A, Mockenhaupt Frank P, Ehrhardt Stephan, Otchwemah, Rowland N, Bienzle, Ulrich, Mockenhaupt, Frank P, J Teun Bousema, Rowland N Otchwemah, Eggelte, Teunis A, Ulrich Bienzle, Stephan Ehrhardt, Otchwemah Rowland N, Sauerwein Robert W, Frank P Mockenhaupt, Robert W Sauerwein   +20 more
core   +1 more source

The multifocal pattern electroretinogram in chloroquine retinopathy [PDF]

, 2004
Purpose: Optimal screening for ocular toxicity caused by chloroquine and hydroxychloroquine is still controversial. With the multifocal pattern electroretinogram (mfPERG), a new electrophysiological technique has recently become available to detect early
Stiefelmeyer, S., Berninger, T., Neubauer, A. S., Arden, G. B., Rudolph, G.   +4 more
core   +1 more source

Long cryopreserved lab-adapted Plasmodium falciparum increases resistance to chloroquine but not its susceptibility

Life Sciences, Medicine and Biomedicine, 2020
Introduction: Plasmodium falciparum (P. falciparum) is a deadly protozoan that is accountable for malaria and chloroquine was the first-line antimalarial drug before its withdrawal and replaced by artemisinin.
Jing Yit Pua, Nurhidanatasha Abu Bakar, Nik Abdul Aziz Nik Kamarudin, Siti Zulaiha Ghazali, Khairul Mohd Fadzli Mustaffa   +4 more
doaj   +1 more source

A purine analog synergizes with chloroquine (CQ) by targeting Plasmodium falciparum Hsp90 (PfHsp90). [PDF]

PLoS ONE, 2013
Drug resistance, absence of an effective vaccine, and inadequate public health measures are major impediments to controlling Plasmodium falciparum malaria worldwide. The development of antimalarials to which resistance is less likely is paramount.
Dea Shahinas, Asongna Folefoc, Tony Taldone, Gabriela Chiosis, Ian Crandall, Dylan R Pillai   +5 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source