Results 51 to 60 of about 2,244,050 (276)

Rapid microarray-based method for monitoring of all currently known single-nucleotide polymorphisms associated with parasite resistance to antimalaria drugs. [PDF]

, 2007
Parasite drug resistance is partly conferred by single-nucleotide polymorphisms (SNPs), and monitoring them has been proposed as an alternative to monitoring drug resistance.
Regös, Attila, Beck, Hans-Peter, Puijalon, Odile, Huber, E., Crameri, A., Regos, A., Crameri, Andreas, Mugittu, K., Felger, Ingrid, Sismeiro, Odile, Laubscher, Daniel, Marfurt, J., Genton, B., Laubscher, D., Puijalon, O., Felger, I., Burki, Richard, Beck, H. P., Coppee, Jean Yves, Genton, Blaise, Maire, N., Coppee, J. Y., Marfurt, Jutta, Mugittu, Kefas, Maire, Nicolas, Burki, R., Huber, Eric, Sismeiro, O.   +27 more
core   +1 more source

Hydro‐ and Lipophilicity of Molecular‐Size‐Controlled Hydrogel Drug Carriers

Advanced Materials Technologies, EarlyView.
We investigate nano‐sized hydrogel drug carriers with tailored hydro‐ and lipophilicity. We design their encapsulation and structure‐forming capabilities and follow them in real time during fabrication using time‐resolved and in situ grazing incidence x‐ray scattering.
Elisabeth Erbes, Naireeta Biswas, Calvin J. Gavillet, Matthias Schwartzkopf, Krishnayan Basuroy, Qing Chen, Andrei Chumakov, Susann Frenzke, Marc Gensch, Korneliya Gordeyeva, Patrycja Kielb, Sonja Kirchner, Volker Körstgens, Peter Müller‐Buschbaum, Henrike M. Müller‐Werkmeister, Jan Rubeck, Sreevidya Thekku Veedu, Jose de Jesus Velazquez‐Garcia, Vivian Waclawek, Daniel Söderberg, Stephan V. Roth, Simone Techert   +21 more
wiley   +1 more source

Integrative Multi‐Omics Analysis Reveals a Mitochondrial–Immune Axis Associated With Neoadjuvant Chemotherapy Response in High‐Grade Serous Ovarian Cancer

Advanced Science, EarlyView.
Integrative multi‐omics analysis delineates a mitochondrial–immune axis governing neoadjuvant chemotherapy response in high‐grade serous ovarian cancer. Immune‐active tumors exhibit enhanced B‐cell infiltration and favorable sensitivity, whereas metabolically rewired tumors display oxidative phosphorylation dependency and resistance.
Wei Jiang, Yi Wang, Xiaohang Lu, Qianlan Yao, Libing Xiang, Xu Cai, Xiaoyu Tu, Shaoxian Tang, Ying Xu, Yufan Cheng, Liming Shen, Huijuan Yang   +11 more
wiley   +1 more source

Chloroquine clinical failures in P. falciparum malaria are associated with mutant Pfmdr-1, not Pfcrt in Madagascar.

PLoS ONE, 2010
Molecular studies have demonstrated that mutations in the Plasmodium falciparum chloroquine resistance transporter gene (Pfcrt) play a major role in chloroquine resistance, while mutations in P.
Valérie Andriantsoanirina, Arsène Ratsimbasoa, Christiane Bouchier, Magali Tichit, Martial Jahevitra, Stéphane Rabearimanana, Rogelin Raherinjafy, Odile Mercereau-Puijalon, Rémy Durand, Didier Ménard   +9 more
doaj   +1 more source

METODE PENENTUAN RESISTENSI PLASMODIUM VIVAX TERHADAP KLOROKUIN

Majalah Kedokteran Andalas, 2008
AbstrakKlorokuin merupakan obat pilihan pertama selama lebih kurang 50 tahun untuk pengobatan malaria vivax, karena kerjanya cepat, murah, dan aman diberikan pada bayi dan wanita hamil. Sejak 1989 muncul beberapa laporan resistensi P.
Nurhayati Nurhayati
doaj   +1 more source

Short Report: Association Between Chloroquine and Amodiaquine Resistance and Allelic Variation in the Plasmodium Falciparum Multiple Drug Resistance 1 Gene and the Chloroquine Resistance Transporter Gene in Isolates from the Upper Nile in Southern Sudan. [PDF]

, 2003
Amodiaquine, a 4-aminoquinoline compound, is being considered as an alternative to chloroquine and pyrimethamine/sulfadoxine where resistance in Plasmodium falciparum to both drugs has been selected.
Nzila, A, van den Broek, I, Keus, K, Ochong, E   +3 more
core  

Effects of piperaquine, chloroquine, and amodiaquine on drug uptake and of these in combination with dihydroartemisinin against drug-sensitive and -resistant Plasmodium falciparum strains

, 2007
Piperaquine is being developed as a long-acting component in artemisinin combination therapies. It was highly active in vitro and drug interaction studies showed that dihydroartemisinin combinations with piperaquine, chloroquine, and amodiaquine were ...
Adagu, IS, Warhurst, David C, Fivelman, Quinton L, Fivelman, QL, Adagu, Ipemida S, Warhurst, DC   +5 more
core   +1 more source

World Antimalarial Resistance Network (WARN) III: Molecular markers for drug resistant malaria [PDF]

, 2007
Molecular markers for drug resistant malaria represent public health tools of great but mostly unrealized potential value. A key reason for the failure of molecular resistance markers to live up to their potential is that data on the their prevalence is ...
Sibley, CH, Happi Christian T, Mbacham, W, Mugittu, K, Sutherland Colin J, Zimmerman, Peter A., Joshi, HH, Barnwell, JW, Naidoo, I, Happi, Christian T., Sutherland, Colin J, Sibley Carol H, Price Ric N, Mbacham, Wilfred, Happi, Christian T, Rosenthal Philip J, Barnwell, John W., Meshnick, Steven R, Shafer, RW, Plowe, CV, Roper, Cally, Zimmerman, PA, Sibley, Carol Hopkins, Shafer, Robert W, Barnwell John W, Barnwell, John W, Meshnick Steven R, Shafer, Robert W., Naidoo Inbarani, Sibley, Carol H, Joshi, Hema H., Sutherland, CJ, Meshnick, SR, Shafer Robert W, Rosenthal, Phillip J., Happi, CT, Rosenthal, PJ, Plowe Christopher V, Joshi, Hema H, Plowe, Christopher V., Rosenthal, Philip J, Mugittu Kefas, Roper Cally, Meshnick, Steven R., Zimmerman, Peter A, Sutherland, Colin J., Price, Ric N., Plowe, Christopher V, Mugittu, Kefas, Mbacham Wilfred, Naidoo, Inbarani, Price, RN, Price, Ric N, Zimmerman Peter A, Roper, C, Joshi Hema H, Happi, Christian, Zimmerman, Peter   +57 more
core   +1 more source

Mitochondrial SLC25A46 Rewires Fatty Acid Oxidation to Promote Cell Proliferation and Ferroptosis Evasion in Ovarian Cancer by Stabilizing CACT

Advanced Science, EarlyView.
Mitochondrial SLC25A46 is upregulated in ovarian cancer (OC) and correlates with poor prognosis. SLC25A46 stabilizes CACT to activate fatty acid oxidation, increasing ATP and NADPH production to drive cell proliferation and ferroptosis evasion. SLC25A46 silencing sensitizes OC cells to ferroptosis and carboplatin, offering a promising therapeutic ...
Yunge Gao, Jiatao Hao, Xiaohong Zhang, Meiting Long, Yujing Feng, Xiaoyue Liu, Xuejian Li, Shujuan Liu, Xin Guo, Xiaohui Lv   +9 more
wiley   +1 more source

Expression levels of pvcrt-o and pvmdr-1 are associated with chloroquine resistance and severe Plasmodium vivax malaria in patients of the Brazilian Amazon.

PLoS ONE, 2014
Molecular markers associated with the increase of chloroquine resistance and disease severity in Plasmodium vivax are needed. The objective of this study was to evaluate the expression levels of pvcrt-o and pvmdr-1 genes in a group of patients presenting
Gisely C Melo, Wuelton M Monteiro, André M Siqueira, Siuhelem R Silva, Belisa M L Magalhães, Aline C C Alencar, Andrea Kuehn, Hernando A del Portillo, Carmen Fernandez-Becerra, Marcus V G Lacerda   +9 more
doaj   +1 more source