Results 61 to 70 of about 2,436,233 (271)

Effect of chloroquine on Candida albicans biofilms and its drug resistance [PDF]

Kouqiang yixue
Objective To evaluate the effects of chloroquine alone and in combination with traditional antifungal agents on the Candida albicans biofilms and its drug resistance.
WU Qiaochu, SHI Banruo, MIAO Haochen, WEI Xin
doaj   +1 more source

Chloroquine Resistance Modulated in Vitro by Expression Levels of the Plasmodium falciparum Chloroquine Resistance Transporter [PDF]

Journal of Biological Chemistry, 2003
Plasmodium falciparum malaria is increasingly difficult to treat and control due to the emergence of parasite resistance to the major antimalarials, notably chloroquine. Recent work has shown that the chloroquine resistance phenotype can be conferred by multiple amino acid mutations in the parasite digestive vacuole transmembrane protein PfCRT.
Karena L, Waller, Rebecca A, Muhle, Lyann M, Ursos, Paul, Horrocks, Dominik, Verdier-Pinard, Amar Bir Singh, Sidhu, Hisashi, Fujioka, Paul D, Roepe, David A, Fidock   +8 more
openaire   +2 more sources

Effects of piperaquine, chloroquine, and amodiaquine on drug uptake and of these in combination with dihydroartemisinin against drug-sensitive and -resistant Plasmodium falciparum strains

, 2007
Piperaquine is being developed as a long-acting component in artemisinin combination therapies. It was highly active in vitro and drug interaction studies showed that dihydroartemisinin combinations with piperaquine, chloroquine, and amodiaquine were ...
Adagu, IS, Warhurst, David C, Fivelman, Quinton L, Fivelman, QL, Adagu, Ipemida S, Warhurst, DC   +5 more
core   +1 more source

Deubiquitination of Vangl by USP6 and USP32 Regulates Planar Cell Polarity Signaling

Advanced Science, EarlyView.
Compartment‐specific deubiquitination controls Vangl dosage and planar cell polarity signaling. USP6 and USP32 regulate distinct subcellular pools of Vangl by removing distinct ubiquitin modifications from Vangl proteins. This regulatory mechanism safeguards PCP‐dependent embryonic morphogenesis, while aberrant USP32‐dependent stabilization of VANGL ...
Fangzi Zha, Di Feng, Ziru Xue, Zhiying Liu, Xiaochen Lin, Zhe Wang, Ling Xu, Jasper Fuk Woo Chan, Martin Cheung, Michael Shing Yan Huen, Yusong Guo, Kui Ming Chan, Yun Liu, Bo Gao   +13 more
wiley   +1 more source

Significant geographical differences in prevalence of mutations associated with Plasmodium falciparum and Plasmodium vivax drug resistance in two regions from Papua New Guinea [PDF]

, 2015
Drug resistance remains a major obstacle to malaria treatment and control. It can arise and spread rapidly, and vary substantially even at sub-national level.
Jonah Iga (175169), Barnadas, Céline, Zimmerman, Peter A., Timinao, Lincoln, Koepfli, Cristian, Peter Siba (112258), Sarah Javati (464175), John Reeder (3400391), Kiniboro, Benson, Ivo Mueller (46609), Senn, Nicolas, Javati, Sarah, Iga, Jonah, Malau, Elisheba, Rare, Lawrence, Mueller, Ivo, Elisheba Malau (3518690), Benson Kiniboro (191309), Lincoln Timinao (423264), CĂŠline Barnadas (3506528), Siba, Peter, Timothy Davis (268628), Harin Karunajeewa (336719), Davis, Timothy M., Leanne Robinson (175144), Reeder, John C., Nicolas Senn (137902), Peter Zimmerman (34037), Robinson, Leanne J., Siba, Peter M., Karunajeewa, Harin, Cristian Koepfli (191306), Lawrence Rare (377507), Kiniboro, B, Koepfli, C, Reeder, JC, Javati, S, Malau, E, Zimmerman, PA, Barnadas, C, Mueller, I, Siba, PM, Robinson, LJ, Karunajeewa, H, Timinao, L, Senn, N, Davis, TM, Rare, L, Iga, J   +48 more
core   +1 more source

Cancer‐Associated Fibroblasts Promote Glucose Metabolic Reprogramming and Progression of Triple‐Negative Breast Cancer via Exosomal circFAD104‐Mediated Intercellular Communication

Advanced Science, EarlyView.
CAF‐derived exosomes deliver circFAD104 into TNBC cells, where it acts as a molecular scaffold that bridges the E3 ligase MARCHF8 and PGM1, promoting MARCHF8‐mediated K48‐linked ubiquitination and proteasomal degradation of PGM1. Loss of PGM1 redirects glucose‐phosphate flux from glycogen synthesis toward glycolysis, thereby driving stemness, EMT, and ...
Lei Wang, Xiaoyan Li, Yiran Liang, Yifei Wang, Yuhan Jin, Jianing Wang, Dan Luo, Yuxia Yang, Jingze Yang, Yaming Li, Tong Chen, Dianwen Han, Zekun Wang, Wenjing Zhao, Bing Chen, Lijuan Wang, Qifeng Yang   +16 more
wiley   +1 more source

Field chloroquine-resistance determinants

, 1997
Although sequence changes in the malarial multidrug-resistance gene, Pfmdr1, such as asn86tyr, have been linked with chloroquine-resistance in a collection of routinely cultured, laboratory strains of Plasmodium falciparum, an experimental cross ...
Carucci, D, Ogala, W, Duraisingh, M, Warhurst, D, Adagu, I   +4 more
core   +3 more sources

1H-NMR metabolite profiles of different strains of Plasmodium falciparum

Bioscience Reports, 2014
Although efforts to understand the basis for inter-strain phenotypic variation in the most virulent malaria species, Plasmodium falciparum, have benefited from advances in genomic technologies, there have to date been few metabolomic studies of this ...
Rongwei Teng, Adele M. Lehane, Markus Winterberg, Sarah H. Shafik, Robert L. Summers, Rowena E. Martin, Donelly A. van Schalkwyk, Pauline R. Junankar, Kiaran Kirk   +8 more
doaj   +1 more source

Mutant KRAS‐m6A Epitranscriptome Axis Promotes Colorectal Cancer and is a Therapeutic Target

Advanced Science, EarlyView.
Mutant KRAS‐m6A axis promotes colorectal cancer (CRC) progression. Mutant KRAS stabilizes METTL3, leading to increased m6A‐modified BCL9L mRNA and translation of BCL9L protein. BCL9L in turn mediates TGF‐β secretion to induce differentiation of Treg and an immunosuppressive microenvironment.
Danyu Chen, Pingmei Huang, Ruizhi Tao, Fenfen Ji, Qinyao Wei, Lok Hin Ko, Lianxin Zhou, Huarong Chen, Alvin Cheung, Wei Kang, Ko Fai To, Jun Yu, Chi Chun Wong   +12 more
wiley   +1 more source

Evaluation of chloroquine therapy for vivax and falciparum malaria in southern Sumatra, western Indonesia

Malaria Journal, 2010
Background Chloroquine was used as first-line treatment for Plasmodium falciparum or Plasmodium vivax in Indonesia before the initial launch of artemisinin combination therapy in 2004. A study to evaluate efficacies of chloroquine against P.
Laihad Ferdinand, Ling Liem, Endawati Dedeh, Sutanto Inge, Setiabudy Rianto, Baird J Kevin   +5 more
doaj   +1 more source