Results 71 to 80 of about 2,244,050 (276)
On the Mechanism of Chloroquine Resistance in Plasmodium falciparum
PLoS ONE, 2010 Resistance to chloroquine of malaria strains is known to be associated with a parasite protein named PfCRT, the mutated form of which is able to reduce chloroquine accumulation in the digestive vacuole of the pathogen. Whether the protein mediates extrusion of the drug acting as a channel or as a carrier and which is the protonation state of its ...
CHINAPPI, MAURO +3 more
openaire +7 more sources
Chloroquine Resistance Modulated in Vitro by Expression Levels of the Plasmodium falciparum Chloroquine Resistance Transporter [PDF]
Journal of Biological Chemistry, 2003 Plasmodium falciparum malaria is increasingly difficult to treat and control due to the emergence of parasite resistance to the major antimalarials, notably chloroquine. Recent work has shown that the chloroquine resistance phenotype can be conferred by multiple amino acid mutations in the parasite digestive vacuole transmembrane protein PfCRT.
Karena L, Waller +8 more
openaire +2 more sources
, 2007 OBJECTIVE: To compare the parasitological failure rates of under-fives and pregnant women with parasitaemia treated with chloroquine (CQ) or sulphadoxine-pyrimethamine (SP).
Ord, Rosalynn +13 more
core +1 more source
Efficacy of Artemether-Lumefantrine in Treatment of Malaria Among Under-Fives and Prevalence of Drug Resistance Markers in Igombe-Mwanza, North-Western Tanzania. [PDF]
, 2012 \ud \ud Drug resistance to anti-malarials is a major public health problem worldwide. This study aimed at establishing the efficacy of artemether-lumefantrine (ACT) in Igombe-Mwanza, north-western Tanzania after a few years of ACT use, and establish the ...
Kamugisha, Erasmus +20 more
core +1 more source
Advanced Science, EarlyView.In diabetic kidney disease, elevated podocyte ANGPTL4 is linked to reduced TFEB nuclear localization and compromised lysosomal degradative function. These changes impair podocyte lipophagy and promote lipid‐droplet accumulation and podocyte injury, which may contribute to renal injury progression.
Xiaojing Liu +7 more
wiley +1 more source
Malaria Journal, 2010 Background Chloroquine was used as first-line treatment for Plasmodium falciparum or Plasmodium vivax in Indonesia before the initial launch of artemisinin combination therapy in 2004. A study to evaluate efficacies of chloroquine against P.
Laihad Ferdinand +5 more
doaj +1 more source
Pathogens, 2020 Background: Early recurrence of Plasmodium vivax is a challenge for malaria control in the field, particularly because this species is associated with lower parasitemia, which hinders diagnosis and monitoring through blood smear testing.
Laila R. A. Barbosa +10 more
doaj +1 more source
Advanced Science, EarlyView.Ischemia‐reperfusion reduces Sirt6 activity, thereby increasing Miro1 acetylation. Hyperacetylated Miro1 exhibits perinuclear distribution and degradation, thereby inducing mitochondrial dysfunction and promoting apoptosis in renal tubular epithelial cells. This pathway reveals a mechanistic link between Sirt6‐mediated deacetylation and Miro1 stability
Lin Wu +12 more
wiley +1 more source
Emerging Infectious Diseases, 2020 Haiti is striving for zero local malaria transmission by the year 2025. Chloroquine remains the first-line treatment, and sulfadoxine/pyrimethamine (SP) has been used for mass drug-administration pilot programs.
Eric Rogier +16 more
doaj +1 more source
How Sulfadoxine-Pyrimethamine (SP) was Perceived in some Rural Communities After Phasing Out Chloroquine (CQ) as a First-Line Drug for Uncomplicated Malaria in Tanzania: Lessons to Learn Towards Moving from Monotherapy to Fixed Combination Therapy. [PDF]
, 2006 Malaria is a leading cause of death in Sub-Saharan Africa. Tanzania changed its malaria treatment policy from chloroquine (CQ) to Sulphadoxine-Pyrimethamine (SP) as first line drug in August 2001. We wanted to assess the perception and behaviour about SP
Nsimba Stephen ED +2 more
core +1 more source