Results 71 to 80 of about 2,436,233 (271)

Diverse mutational pathways converge on saturable chloroquine transport via the malaria parasite's chloroquine resistance transporter [PDF]

, 2015
Mutations in the chloroquine resistance transporter (PfCRT) are the primary determinant of chloroquine (CQ) resistance in the malaria parasite Plasmodium falciparum.
Bellanca, Sebastiano, Stein, Wilfred D., Schenk, Robyn, Dolstra, Tegan, Marchetti, Rosa, Sanchez, Cecilia P., Dave, Anurag, Goh, Xin-Lin, Lanzer, Michael, Richards, Sashika, Nash, Megan, Kirk, Kiaran, Martin, Rowena, Summers, Robert   +13 more
core   +1 more source

Lyssavirus Nucleoprotein Induces GPAT4‐Mediated CYB5R1 Depalmitoylation to Suppress Ferroptosis and Promote Viral Replication

Advanced Science, EarlyView.
Lipid metabolism plays a vital role in viral infections. Here, we reveal that the lyssavirus N protein regulates GPAT4 to induce lipid droplet biogenesis, restricting CYB5R1 palmitoylation and reducing ferroptosis susceptibility to ultimately promote viral replication.
Jianqing Zhao, Chuan Liang, Pingping Chen, Meixin Sun, Zhen F. Fu, Ling Zhao, Ming Zhou   +6 more
wiley   +1 more source

Prevalence of molecular markers of chloroquine resistance in malaria parasites in East Africa: A systematic review and meta-analysis

Journal of Global Antimicrobial Resistance
Background: Malaria is a serious global public health problem, which is caused by genus Plasmodium. Resistance of the human malaria parasite to antimalarial drugs is a public health concern in malaria endemic countries.
Wagaw Abebe, Amare Mekuanint, Zelalem Asmare, Dagmawi Woldesenbet, Yenesew Mihret, Abebaw Setegn, Tadele Emagneneh   +6 more
doaj   +1 more source

Ajuvant effect of a Synthetic Aluminium - Magnesium Silicate on chloroquine phosphate, against Plasmodium berghei. [PDF]

, 2012
effect of a synthetic Aluminium - Magnesium Silicate (AMS) on antiplasmodial activity of chloroquine was tested. Plasmodium berghei-infected mice were treated with 7 mg/kg, 5 mg/kg and 3 mg/kg chloroquine, respectively.
obianuju obianuju Okoroafor, nnenna elendu-eleke, Augustine Ngene, madike ezeibe   +3 more
core  

Beyond Biomimetics: Pathology‐Informed Engineering Rescues Reconstituted HDL From Inflammatory Dysfunction for Sepsis Immunotherapy

Advanced Science, EarlyView.
A pathology‐informed engineering strategy rescues reconstituted HDL from inflammatory dysfunction in sepsis. By integrating a ceria nanozyme‐celastrol coordination complex, the platform preserves HDL structure and endotoxin handling, sustains hierarchical intracellular delivery, and enhances immunoregulation across pathological models, translating ...
Han Zhou, Lei Zhang, Xingyu Cai, Jiajia Su, Guangyu Dai, Xue Chen, Hanming Wang, Jia Hua, Jianping Liu, Chunmeng Sun, Xiancheng Chen, Erhao Wang, Wenli Zhang   +12 more
wiley   +1 more source

An Ultra-Sensitive Technique: Using Pv-mtCOX1 qPCR to Detect Early Recurrences of Plasmodium vivax in Patients in the Brazilian Amazon

Pathogens, 2020
Background: Early recurrence of Plasmodium vivax is a challenge for malaria control in the field, particularly because this species is associated with lower parasitemia, which hinders diagnosis and monitoring through blood smear testing.
Laila R. A. Barbosa, Emanuelle L. da Silva, Anne C. G. de Almeida, Yanka E. A. R. Salazar, André M. Siqueira, Maria das Graças Costa Alecrim, José Luiz Fernandes Vieira, Quique Bassat, Marcus V. G. de Lacerda, Wuelton M. Monteiro, Gisely C. Melo   +10 more
doaj   +1 more source

Neuron‐Derived Vesicular circMagi1 Restrains Vascular Repair After Ischemic Stroke by Promoting TRIM65‐Mediated ANXA2 Degradation

Advanced Science, EarlyView.
After ischemic stroke, injured neurons transfer circMagi1 to endothelial cells through extracellular vesicles. Within endothelial cells, circMagi1 binds ANXA2 and enhances its engagement with TRIM65, promoting ANXA2 ubiquitination and proteasomal degradation to constrain angiogenic repair.
Youkun Bi, Qun Liu, Baohua Zou, Wenyuan Wang, Xinlong Qiao, Lin Gao, Chaoxu Miao, Ningning Huang, Shuqing Tang, Rui Guo, Changqing Zeng, Ce Jia, Yuanchao Xue, Xuejun Guo, Jianjun Chen, Huiwen Wang, Guangju Ji   +16 more
wiley   +1 more source

Association of house spraying with suppressed levels of drug resistance in Zimbabwe

Malaria Journal, 2004
Background Public health strategies are needed to curb antimalarial drug resistance. Theoretical argument points to an association between malaria transmission and drug resistance although field evidence remains limited.
Chandiwana Steven K, Chimbadzwa Tawanda, Mudyiradima Robert, Mutambu Susan L, Mharakurwa Sungano, Day Karen P   +5 more
doaj   +1 more source

Nationwide Monitoring for Plasmodium falciparum Drug-Resistance Alleles to Chloroquine, Sulfadoxine, and Pyrimethamine, Haiti, 2016–2017

Emerging Infectious Diseases, 2020
Haiti is striving for zero local malaria transmission by the year 2025. Chloroquine remains the first-line treatment, and sulfadoxine/pyrimethamine (SP) has been used for mass drug-administration pilot programs.
Eric Rogier, Camelia Herman, Curtis S. Huber, Karen E.S. Hamre, Baby Pierre, Kimberly E. Mace, Jacquelin Présumé, Gina Mondélus, Ithamare Romilus, Tamara Elismé, Thomas P. Eisele, Thomas Druetz, Alexandre Existe, Jacques Boncy, Jean F. Lemoine, Venkatachalam Udhayakumar, Michelle A. Chang   +16 more
doaj   +1 more source

Chloroquine-resistance-conferring mutations in pfcrt give rise to a chloroquine-associated H+ leak from the malaria parasite's digestive vacuole.

, 2016
Chloroquine resistance in the malaria parasite Plasmodium falciparum is conferred by mutations in the P. falciparum chloroquine resistance transporter (PfCRT).
Kirk, Kiaran, Lehane, Adele
core   +1 more source