Results 91 to 100 of about 2,244,050 (276)

Chloroquine sensitizes biofilms of Candida albicans to antifungal azoles

Brazilian Journal of Infectious Diseases, 2013
Biofilms formed by Candida albicans, a human pathogen, are known to be resistant to different antifungal agents. Novel strategies to combat the biofilm associated Candida infections like multiple drug therapy are being explored.
Ravikumar Bapurao Shinde, Jayant Shankar Raut, Nitin Mahendra Chauhan, Sankunny Mohan Karuppayil   +3 more
doaj   +1 more source

Selection of antimalarial drug resistance after intermittent preventive treatment of infants and children (IPTi/c) in Senegal. [PDF]

, 2013
Our study investigated the possible impact of SP-IPT given to infants and children on the prevalence of SP-resistant haplotypes in the Plasmodium falciparum genes Pfdhfr and Pfdhps, comparing sites with and without IPTi/c. P. falciparum positive samples (
Dieng, Yémou, Sylla, Khadime, Lo, Ami Colle, Jean L. Ndiaye, Ndiaye, Magatte, Khadime Sylla, Hallett, Rachel, Ndiaye, Jean Louis, Magatte Ndiaye, Rachel Hallett, Ndiaye, Jean L, Diouf, Ibrahima, Tine, Roger, Abiola, Annie, Ibrahima Diouf, Ndiaye, Daouda, Aminata C. Lo, Yemou Dieng, Roger Tine, Faye, Babacar, Babacar Faye, Gaye, Oumar, Lo, Aminata C, Oumar Gaye, Michael Alifrangis, Alifrangis, Michael   +25 more
core   +1 more source

Autophagy Orchestrates Anti‐Tumor Immunity to Enhance Chemosensitivity via the FBXW2/C/EBPβ/TIMP‐2 Axis in Colorectal Cancer

Advanced Science, EarlyView.
Chemotherapy leverages tumor‐cell autophagy to reshape the colorectal cancer immune microenvironment. Autophagy degrades FBXW2 to promote C/EBPβ‐mediated TIMP‐2 transcription and MMP‐9 suppression, driving intra‐tumoral CD8+ T‐cell infiltration. Targeting MMP‐2/9 or restoring TIMP‐2 overcomes chemo‐resistance in autophagy‐deficient tumors. ABSTRACT The
Bing Cheng, Chaoying Wei, Zhitong Niu, Jinxin Chen, Guojie Long, Yingzhen Weng, Qiufeng Liu, Yue Jiang, Panpan Wang, Ronghua Zhang, Qiang Yu, Xiaojian Wu, Wenyu Wang   +12 more
wiley   +1 more source

Deubiquitination of Vangl by USP6 and USP32 Regulates Planar Cell Polarity Signaling

Advanced Science, EarlyView.
Compartment‐specific deubiquitination controls Vangl dosage and planar cell polarity signaling. USP6 and USP32 regulate distinct subcellular pools of Vangl by removing distinct ubiquitin modifications from Vangl proteins. This regulatory mechanism safeguards PCP‐dependent embryonic morphogenesis, while aberrant USP32‐dependent stabilization of VANGL ...
Fangzi Zha, Di Feng, Ziru Xue, Zhiying Liu, Xiaochen Lin, Zhe Wang, Ling Xu, Jasper Fuk Woo Chan, Martin Cheung, Michael Shing Yan Huen, Yusong Guo, Kui Ming Chan, Yun Liu, Bo Gao   +13 more
wiley   +1 more source

INDUCTION OF DRUG RESISTANCE IN PLASMODIUM FALCIPARUM: AN INTERMITTENT DRUG EXPOSURE METHOD

Iranian Journal of Public Health, 1998
The production of experimentally induced drug resistance in the laboratory provides valuable opportunities for investigators to study the nature and genetics of drug resistance mechanisms to a given agent, patterns of cross resistance and the mode of ...
M.Nateghpour, S.A.Ward, R.E. Howells   +2 more
doaj  

Collateral hypersensitivity between ZY19489 and piperaquine neutralizes PfCRT-mediated drug efflux and Plasmodium falciparum resistance

Nature Communications
New antimalarial drugs are needed to combat the current emergence and spread of Plasmodium falciparum parasite resistance to artemisinin-based combination therapies.
John Okombo, Tolla Ndiaye, Tarrick Qahash, Igor M. R. Moura, Eva Gil-Iturbe, Laura M. Hagenah, Jessica L. Bridgford, Vinicius Bonatto, Kurt E. Ward, Tomas Yeo, Sunil K. Narwal, Lily V. Orta, Isla Anderson, Satish K. Dhingra, Charisse Flerida A. Pasaje, Heekuk Park, Jonathan Kim, Rafael V. C. Guido, Maria Belén Jiménez-Diaz, Iñigo Angulo-Barturen, Jacquin C. Niles, Filippo Mancia, Anne-Catrin Uhlemann, Sachel Mok, Matthias Quick, Elizabeth A. Winzeler, Didier Leroy, Manuel Llinás, Vandana Thathy, David A. Fidock   +29 more
doaj   +1 more source

Minority-Variant pfcrt K76T Mutations and Chloroquine Resistance, Malawi

Emerging Infectious Diseases, 2007
Genotyping of the chloroquine-resistance biomarker pfcrt (Plasmodium falciparum chloroquine resistance transporter gene) suggests that, in the absence of chloroquine pressure, Plasmodium falciparum parasites in Malawi have reverted to chloroquine ...
Jonathan J. Juliano, Jesse J. Kwiek, Kathryn Cappell, Victor Mwapasa, Steven R Meshnick   +4 more
doaj   +1 more source

Activity of piperaquine and other 4-aminoquinoline antiplasmodial drugs against chloroquine-sensitive and resistant blood-stages of Plasmodium falciparum. Role of beta-haematin inhibition and drug concentration in vacuolar water- and lipid-phases. [PDF]

, 2007
Chloroquine (CQ), a 4-aminoquinoline, accumulates in acidic digestive vacuoles of the malaria parasite, preventing conversion of toxic haematin to beta-haematin.
Guy, R Kiplin, Warhurst, David C, Fivelman, Quinton L, Craig, John C, Adagu, Ipemida S, Madrid, Peter B   +5 more
core   +1 more source

Cancer‐Associated Fibroblasts Promote Glucose Metabolic Reprogramming and Progression of Triple‐Negative Breast Cancer via Exosomal circFAD104‐Mediated Intercellular Communication

Advanced Science, EarlyView.
CAF‐derived exosomes deliver circFAD104 into TNBC cells, where it acts as a molecular scaffold that bridges the E3 ligase MARCHF8 and PGM1, promoting MARCHF8‐mediated K48‐linked ubiquitination and proteasomal degradation of PGM1. Loss of PGM1 redirects glucose‐phosphate flux from glycogen synthesis toward glycolysis, thereby driving stemness, EMT, and ...
Lei Wang, Xiaoyan Li, Yiran Liang, Yifei Wang, Yuhan Jin, Jianing Wang, Dan Luo, Yuxia Yang, Jingze Yang, Yaming Li, Tong Chen, Dianwen Han, Zekun Wang, Wenjing Zhao, Bing Chen, Lijuan Wang, Qifeng Yang   +16 more
wiley   +1 more source

Treatment of Chloroquine-Resistant Plasmodium vivax with Chloroquine and Primaquine or Halofantrine

Journal of Infectious Diseases, 1995
Optimal therapy for infection by chloroquine-resistant Plasmodium vivax has not been established. From 1992 to 1994 during three separate studies, 147 Javanese residents of Irian Jaya infected by P. vivax were treated with either chloroquine (25 mg of base/kg during 3 days or 10 mg of base/kg in one dose) plus primaquine (10 mg/kg during 28 days or 2.5
Baird, J. Kevin, Basri, Hasan, Subianto, Budi, Fryauff, David J., McElroy, Peter D., Leksana, Budhi, Richie, Thomas L., Masbar, Sofyan, Wignall, F. Stephen, Hoffman, Stehen L.   +9 more
openaire   +4 more sources