Results 91 to 100 of about 2,436,233 (271)

Epithelial SLC25A20 Deficiency Drives Immunosuppressive Neutrophil Remodeling via ARG1 Palmitoylation to Promote Colorectal Cancer

Advanced Science, EarlyView.
SLC25A20 deficiency in tumor cells compromises mitochondrial LCFA transport, which suppresses FAO and drives compensatory release of palmitic acid‐enriched lipids into the TME. These tumor‐derived palmitic acids are taken up by TANs, promoting ZDHHC18‐catalyzed ARG1 palmitoylation.
Yue Han, Tian‐Yuan Tan, Bin Zhang, Ye‐Bin Fu, Wen Chen, Min‐Hui Yang, Yi‐Qing Wang, Yan‐Qing Ding, Shuang Wang   +8 more
wiley   +1 more source

Collateral hypersensitivity between ZY19489 and piperaquine neutralizes PfCRT-mediated drug efflux and Plasmodium falciparum resistance

Nature Communications
New antimalarial drugs are needed to combat the current emergence and spread of Plasmodium falciparum parasite resistance to artemisinin-based combination therapies.
John Okombo, Tolla Ndiaye, Tarrick Qahash, Igor M. R. Moura, Eva Gil-Iturbe, Laura M. Hagenah, Jessica L. Bridgford, Vinicius Bonatto, Kurt E. Ward, Tomas Yeo, Sunil K. Narwal, Lily V. Orta, Isla Anderson, Satish K. Dhingra, Charisse Flerida A. Pasaje, Heekuk Park, Jonathan Kim, Rafael V. C. Guido, Maria Belén Jiménez-Diaz, Iñigo Angulo-Barturen, Jacquin C. Niles, Filippo Mancia, Anne-Catrin Uhlemann, Sachel Mok, Matthias Quick, Elizabeth A. Winzeler, Didier Leroy, Manuel Llinás, Vandana Thathy, David A. Fidock   +29 more
doaj   +1 more source

Chloroquine Transport via the Malaria Parasite’s Chloroquine Resistance Transporter

Science, 2009
Malaria Chloroquine Resistance Transporter Malaria is one of the most deadly infectious diseases in the world today, and the emergence and spread of chloroquine-resistant parasites has been a disaster for world health.
Martin, Rowena, Marchetti, Rosa, Cowan, Anna, Howitt, Susan, Broer, Stefan, Kirk, Kiaran   +5 more
openaire   +3 more sources

No genetic bottleneck in Plasmodium falciparum wild-type Pfcrt alleles reemerging in Hainan Island, China, following high-level chloroquine resistance

, 2008
Chloroquine-resistant Plasmodium falciparum was highly prevalent in Hainan, China, in the 1970s. Twenty-five years after cessation of chloroquine therapy, the prevalence of P.
Gao, Qi, Cheng, Qin, Wang, Shanqing, Gatton, Michelle L., Chen, Nanhua, Wang, Guangze   +5 more
core   +1 more source

Mitochondrial Localization of Cx26 Promotes Colorectal Cancer Malignancy and Exposes a Fatal Vulnerability to Drug Targeting

Advanced Science, EarlyView.
Mitochondrial localization of Cx26 emerges as a double‐edged sword in colorectal cancer. PIMT‐mediated methylation of Cx26 promotes its mitochondrial localization and stability. Mitochondrial Cx26 then facilitates ER‐mitochondria communication and Ca2+ signaling, thereby promoting metastatic progression. Bortezomib exploits this malignant adaptation by
Jie Wang, Lu Chen, Jia Qin, Xiaoning Wang, Sunlan Ye, Ning An, Mei Bai, Yan Shen, Xuefeng Wu, Qiang Xu   +9 more
wiley   +1 more source

High-level chloroquine resistance in Sudanese isolates of Plasmodium falciparum is associated with mutations in the chloroquine resistance transporter gene pfcrt and the multidrug resistance Gene pfmdr1. [PDF]

, 2001
Polymorphisms were examined in 2 Plasmodium falciparum genes, as were chloroquine responses of clones and isolates from a village in eastern Sudan. There was a significant association between an allele of the P.
Hunt, P, Hamza A. Babiker, P. Hunt, Pringle, SJ, Walliker, D, Abdel-Muhsin, A, Babiker, HA, Mackinnon, M, S. J. Pringle, M. Mackinnon, A. Abdel‐Muhsin, D. Walliker   +11 more
core   +1 more source

Low‐Density Lipoprotein Receptor‐Targeted Biomimetic Nanoplatform Suppresses Glioblastoma Stemness and Remodels Antitumor Immunity via Dual Metabolic Disruption

Advanced Science, EarlyView.
A low‐density lipoprotein receptor‐oriented biomimetic nanoplatform couples brain‐tumor delivery with a mechanistically matched regorafenib‐erythrodiol combination. Concurrent disruption of autophagic nutrient salvage and cholesterol homeostasis collapses bioenergetic and signaling support, suppresses glioblastoma stemness, and promotes immunogenic ...
Yining Jiang, Wenzhuo Yang, Wenting Cheng, Jing Zuo, Lin Pan, Sheng Zhong, Ren Geng, Yao Zhao, Zijian Chen, Canhua Huang, Yang Bai, Liyan Zhao, Yunqian Li   +12 more
wiley   +1 more source

Treatment of Chloroquine-Resistant Plasmodium vivax with Chloroquine and Primaquine or Halofantrine

Journal of Infectious Diseases, 1995
Optimal therapy for infection by chloroquine-resistant Plasmodium vivax has not been established. From 1992 to 1994 during three separate studies, 147 Javanese residents of Irian Jaya infected by P. vivax were treated with either chloroquine (25 mg of base/kg during 3 days or 10 mg of base/kg in one dose) plus primaquine (10 mg/kg during 28 days or 2.5
Baird, J. Kevin, Basri, Hasan, Subianto, Budi, Fryauff, David J., McElroy, Peter D., Leksana, Budhi, Richie, Thomas L., Masbar, Sofyan, Wignall, F. Stephen, Hoffman, Stehen L.   +9 more
openaire   +4 more sources

Plasmodium falciparum malaria resistance to chloroquine in five communities in Southern Nigeria [PDF]

, 2004
Chloroquine is still a first-line antimalarial drug in uncomplicated falciparum malaria. Increasing resistance to chloroquine has been reported in many parts of Nigeria.
Erah, Patrick O, Okhamafe, Augustine O, Arienmughare, Gertrude   +2 more
core   +1 more source

Tumor‐Intrinsic HEXB Drives Endothelial‐To‐Mesenchymal Transition and Confers Resistance to Anti‐Angiogenic Therapy in Glioblastoma

Advanced Science, EarlyView.
This study elucidates how glioblastoma tumors develop resistance to anti‐VEGF therapy through endothelial‐to‐mesenchymal transition (Endo‐MT). The researchers identify a novel signaling pathway where tumor‐derived HEXB stabilizes HSP60 to drive this vascular reprogramming.
Tianqi Liu, Xin Chen, Tao Sun, Jianqi Wu, Haixu Yan, Xing Liu, Hongda Lin, Xiangyu Wang, Ziao Xiao, Yang Xu, Qiang Fu, Peng Cheng, Wen Cheng, Anhua Wu   +13 more
wiley   +1 more source