Results 111 to 120 of about 2,436,233 (271)

PIAS3 CircRNA‐Loaded Lipid Nanoparticles Restore ALOX15 SUMOylation to Suppress Cementoblast Ferroptosis and Attenuate Orthodontically Induced Root Resorption

Advanced Science, EarlyView.
Orthodontic compression suppresses PIAS3 expression in cementoblasts, impairing ALOX15 SUMOylation and ubiquitin‐mediated degradation, which leads to ALOX15 accumulation, lipid peroxidation, ferroptosis, and osteoclastogenesis. Local delivery of PIAS3 circRNA‐loaded lipid nanoparticles restores the PIAS3–ALOX15 regulatory pathway, alleviates ...
Yifei Hou, Chongzheng Yan, Xinrui Xu, Zihan Yang, Xinhui Wu, Hongxu Zhao, Xuan Song, Jianing Zhang, Yijing Li, Aohua Yang, Xiamei Lu, Yi Liu   +11 more
wiley   +1 more source

Ischemic Postconditioning Protects Aged Myocardium Against Ischemia/Reperfusion Injury by Regulating Mitochondrial Dynamics via piR‐4913

Advanced Science, EarlyView.
A tiny RNA tips the scales of cardiac injury in aging. piR‐4913 recruits OGT to Drp1 and drives its O‐GlcNAcylation at Thr604, promoting excessive mitochondrial fission that aggravates ischemia‐reperfusion injury. Ischemic postconditioning silences this pathway to restore mitochondrial balance and protect the aged myocardium, revealing piR‐4913 as a ...
Xiangyu Zhao, Yanchun Li, Nan Li, Juan Zhang, Xiaolong Ma, Fei Yang, Ruihan Long, Yining Tian, Yichen Wang, Shengchao Ma, Huiping Zhang, Yideng Jiang   +11 more
wiley   +1 more source

Comparison of the therapeutic efficacy of chloroquine and sulphadoxine-pyremethamine in children and pregnant women.

, 2007
OBJECTIVE: To compare the parasitological failure rates of under-fives and pregnant women with parasitaemia treated with chloroquine (CQ) or sulphadoxine-pyrimethamine (SP).
Ord, Rosalynn, Daniel Chandramohan, Jane Bruce, Chandramohan, Daniel, Randall, Anna, Tagbor, Harry, Harry Tagbor, Edmund Browne, Anna Randall, Browne, Edmund, Rosalynn Ord, Greenwood, Brian, Brian Greenwood, Bruce, Jane   +13 more
core   +1 more source

In vitro piperaquine susceptibility is not associated with the Plasmodium falciparum chloroquine resistance transporter gene [PDF]

, 2013
International audienceBackgroundDihydroartemisinin-piperaquine is a new ACT that is administered as single daily dose for three days and has been demonstrated to be tolerated and highly effective for the treatment of uncomplicated Plasmodium falciparum ...
Daniel Parzy, Madamet, Marilyn, Cren, Julien, Taudon, Nicolas, Dominique Travers, Benoit, Nicolas, Amalvict, Rémy, Travers, Dominique, Bertaux, Lionel, Aurélie Pascual, Rogier, Christophe, Bruno Pradines, Nicolas Taudon, Nicolas Benoit, Lionel Bertaux, Parzy, Daniel, Marilyn Madamet, Julien Cren, null null, Rémy Amalvict, Pascual, Aurélie, Pradines, Bruno, Christophe Rogier   +22 more
core   +1 more source

CircFAM65A/CANX Condensates Sequester FAM134B to Inhibit ER‐phagy and Suppress Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
The novel circRNA circFAM65A suppresses HCC progression. Mechanistically, circFAM65A drives CANX phase separation, which recruits FAM134B into condensates and blocks its interaction with LC3, thereby inhibiting ER‐phagy and HCC progression. Importantly, targeted circFAM65A delivery represents a potential therapeutic strategy for HCC.
Wenxiu Ru, Lunbiao Gan, Yu Lu, Yujing Guo, Qian Huang, Sha Yin, Fengze Nie, Sijia Di, Jiaqi Ning, Siyu Yao, Huanhuan Wan, Le Liu, Zehua Liu, Fa Yang, Weijun Qin, Weihong Wen   +15 more
wiley   +1 more source

Cross sectional study to determine chloroquine resistance among Plasmodium falciparum clinical isolates from Khartoum, Sudan [version 1; referees: 1 approved, 2 approved with reservations]

F1000Research, 2018
Background:  Malaria continues to present a global health threat; the World Health Organization (WHO) reported 214 million cases of malaria by the year 2015 with a death rate of 438000.
Walaa Salah Abdulla Mohammed, Kyakonye Yasin, N.S. Mahgoub, Muzamil Mahdi Abdel Hamid   +3 more
doaj   +1 more source

In-vivo efficacy of amodiaquine-artesunate in children with uncomplicated Plasmodium falciparum malaria in western Kenya.

, 2009
OBJECTIVES: To assess the efficacy of amodiaquine-artesunate in an area with high chloroquine resistance in western Kenya. METHODS: Twenty-eight day in-vivo efficacy trial of amodiaquine-artesunate in 103 children aged 6-59 months in western Kenya with ...
Thwing, JI, Slutsker, L, Odero, CO, McMorrow, M, Hamel, MJ, Desai, M, Odhiambo, FO, Otieno, KO, Kariuki, S, Roper, C, Vulule, J, Newman, RD, Ord, R   +12 more
core   +1 more source

Chloroquine/sulphadoxine-pyrimethamine for gambian children with malaria: transmission to mosquitoes of multidrug-resistant Plasmodium falciparum. [PDF]

, 2006
OBJECTIVES: In the Gambia, chloroquine (CQ) plus sulphadoxine-pyrimethamine (SP) is the first-line antimalarial treatment. Plasmodium falciparum parasites carrying mutations associated with resistance to each of these drugs were present in 2001 but did ...
Pinder Margaret, Jawara Musa, Targett Geoffrey A. T, Ord, Rosalynn, Hallett, Rachel L, Walraven, Gijs, Sutherland Colin J, Targett, Geoffrey AT, Alloueche Ali, Jawara, Musa, Dunyo, Samuel, Alexander Neal, Sutherland, Colin J, Randall, Anna, Walraven Gijs, Ord Rosalynn, Alexander, Neal, Hallett Rachel L, Dunyo Samuel, Pinder, Margaret, Alloueche, Ali, Randall Anna   +21 more
core   +1 more source

DTX3 Suppresses the NPM3–RUVBL1 Axis to Inhibit Homologous Recombination Repair and Abrogate Tumor Radioresistance

Advanced Science, EarlyView.
Deltex 3 (DTX3) catalyzes K27‐linked ubiquitination of nucleophosmin 3 to disrupt homologous recombination repair and reverse tumor radioresistance. Low DTX3 predicts poor survival and radiotherapy recurrence, serving as a radiosensitizing therapeutic target.
Jia‐Hao Xiao, Chang‐Jun Xie, Yan‐Hua Chen, Hao Cheng, Shuang‐Hui Li, Wei Li, Ya‐Wen Bin, Rui‐Min He, Ying‐Qing Li, Ping Feng   +9 more
wiley   +1 more source

pH-dependence of the Plasmodium falciparum chloroquine resistance transporter is linked to the transport cycle. [PDF]

Nat Commun, 2023
Berger F, Gomez GM, Sanchez CP, Posch B, Planelles G, Sohraby F, Nunes-Alves A, Lanzer M.   +7 more
europepmc   +1 more source