Results 111 to 120 of about 2,244,050 (276)

chloroquine resistance

, 2005
Recent studies have highlighted the importance of a parasite protein referred to as the chloroquine resistance transporter (PfCRT) in the molecular basis of Plasmodium falciparum resistance to the quinoline antimalarials.
Kiaran Kirk, Tilley, Leann, Rowena E. Martin, David A. Fidock, Ward, Steve, Martin, Rowena E., Kirk, Kiaran, Patrick G. Bray, Bray, Patrick G., Stephen A. Ward, Fidock, David A., Leann Tilley   +11 more
core   +1 more source

Recent Advances in Virus–Host Interactions, Antiviral Bioactive Compounds, and Breeding for Disease Resistance of Porcine Epidemic Diarrhea Virus

Animal Research and One Health, EarlyView.
Basic research on the PEDV infection cycle and virus–host interactions advances the development of anti‐PEDV drugs and disease‐resistant breeding and helps strengthen disease prevention and control while reducing economic losses in the swine industry.
Heyong Wu, Aosi Qi, Shuyu Zhong, Haozhen Du, Shimeng Guo, Hongsheng Ouyang, Hongming Yuan, Daxin Pang, Zicong Xie   +8 more
wiley   +1 more source

Cross sectional study to determine chloroquine resistance among Plasmodium falciparum clinical isolates from Khartoum, Sudan [version 1; referees: 1 approved, 2 approved with reservations]

F1000Research, 2018
Background:  Malaria continues to present a global health threat; the World Health Organization (WHO) reported 214 million cases of malaria by the year 2015 with a death rate of 438000.
Walaa Salah Abdulla Mohammed, Kyakonye Yasin, N.S. Mahgoub, Muzamil Mahdi Abdel Hamid   +3 more
doaj   +1 more source

CASTOR1 Regulates Humoral Immune Responses and Contributes to the Pathogenesis of Systemic Lupus Erythematosus

Arthritis &Rheumatology, EarlyView.
Objective CASTOR1 senses arginine and regulates mammalian target of rapamycin complex 1 (mTORC1), a central metabolic signaling molecule. This study aimed to elucidate the roles of CASTOR1 in humoral immune responses. Methods We analyzed human B cell transcriptomes from healthy controls and patients with systemic lupus erythematosus (SLE) via ...
Takeshi Kusuda, Toshihiko Komai, Takahiro Itamiya, Tatsuki Abe, Tomohisa Okamura, Keishi Fujio   +5 more
wiley   +1 more source

REVERSAL OF HALOFANTRINE RESISTANCE IN PLASMODIUM FALCIPARUM BY PENFLURIDOL IN VITRO [PDF]

Iranian Journal of Public Health, 1998
Penfluridol, a neuroleptic drug, considerably reversed halofantrine resistance in T9.96HF halofantrine resistant strain of Plasmodium falicparum (originally chloroquine sensitive parasites), but not in K1HF halofantrine resistant strain (originally ...
M. Nateghpour, R.E. Howells, S.A. Ward   +2 more
doaj   +1 more source

Molecular detection of drug resistant malaria in Southern Thailand

Malaria Journal, 2019
Background Drug resistance within the major malaria parasites Plasmodium vivax and Plasmodium falciparum threatens malaria control and elimination in Southeast Asia.
Chaturong Noisang, Christiane Prosser, Wieland Meyer, Waenurama Chemoh, John Ellis, Nongyao Sawangjaroen, Rogan Lee   +6 more
doaj   +1 more source

ACT Now or Later: The Economics of Malaria Resistance [PDF]

In the past, malaria control efforts in sub-Saharan Africa have relied on a combination of vector control and effective treatment using chloroquine. With increasing resistance to chloroquine, attention has now turned to alternative treatment strategies ...
Laxminarayan, Ramanan
core  

In-vivo efficacy of amodiaquine-artesunate in children with uncomplicated Plasmodium falciparum malaria in western Kenya.

, 2009
OBJECTIVES: To assess the efficacy of amodiaquine-artesunate in an area with high chloroquine resistance in western Kenya. METHODS: Twenty-eight day in-vivo efficacy trial of amodiaquine-artesunate in 103 children aged 6-59 months in western Kenya with ...
Thwing, JI, Slutsker, L, Odero, CO, McMorrow, M, Hamel, MJ, Desai, M, Odhiambo, FO, Otieno, KO, Kariuki, S, Roper, C, Vulule, J, Newman, RD, Ord, R   +12 more
core   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

pH-dependence of the Plasmodium falciparum chloroquine resistance transporter is linked to the transport cycle. [PDF]

Nat Commun, 2023
Berger F, Gomez GM, Sanchez CP, Posch B, Planelles G, Sohraby F, Nunes-Alves A, Lanzer M.   +7 more
europepmc   +1 more source