Results 101 to 110 of about 2,436,233 (271)

Hepatic Lipid Stress Drives Metabolic Dysfunction‐Associated Steatohepatitis Progression through FTO O‐GlcNAcylation‐Induced m6A Demethylation of HRAS

Advanced Science, EarlyView.
Lipid stress drives O‐GlcNAcylation of the m6A demethylase FTO at Ser195, enhancing its stability and demethylase activity. This modification removes m6A from HRAS mRNA, preventing its degradation and activating PI3K/AKT signaling to promote hepatic steatosis and inflammation.
Jia‐Xin Yin, Yan‐Lai Zhang, Qun Liu, Rui Liu, Hai‐Yang Yuan, Sui‐Dan Chen, Ming‐Hua Zheng, Kai Wang, Ni Tang, Ai‐Long Huang   +9 more
wiley   +1 more source

The “pushmi-pullyu” of resistance to chloroquine in malaria

, 2017
Malarial infection continues to impart devastating health problems in the developing world. Treatment of malaria has involved chemotherapy since 168 BC, with the most prevalent and successful forms using plant alkaloids.
Ruth Skrzypek, Richard Callaghan
core   +2 more sources

Use of chloroquine in uncomplicated falciparum malaria chemotherapy : The past, the present and the future

Sahel Medical Journal, 2010
Chloroquine is a 4-aminoquinoline discovered over five decades ago for treatment of uncomplicated malaria. It was widely used as first line treatment and prophylaxis for individuals going into malaria endemic regions.
Balogun S T, Sani M D, Fehintola F A, Sandabe   +3 more
doaj  

The relationship of physico-chemical properties and structure to the differential antiplasmodial activity of the cinchona alkaloids. [PDF]

, 2003
BACKGROUND: The 8-amino and 9-hydroxy substituents of antimalarial cinchona alkaloids have the erythro orientation while their inactive 9-epimers are threo.
Meyer David J, Adagu Ipemida S, Adagu, Ipemida S, Warhurst David C, Sylvia Y Lee, Meyer, David J, David C Warhurst, Craig John C, David J Meyer, Warhurst, David C, Lee, Sylvia Y, Ipemida S Adagu, Craig, John C, John C Craig, Lee Sylvia Y   +14 more
core   +1 more source

NSUN3‐Associated m5C Modification of tRF5‐GlyTCC Suppresses Colorectal Cancer Progression via RPL23‐Linked Nucleolar Stress and p53‐Associated Autophagy and Enhances 5‐FU Sensitivity

Advanced Science, EarlyView.
This study identifies that NSUN3‐mediated m5C modification stabilizes tRF5‐GlyTCC, linking ribosomal homeostasis, nucleolar stress responses, and p53 signaling changes. This regulatory axis suppresses colorectal cancer and enhances chemotherapy response to 5‐FU, positioning tRF5‐GlyTCC as a potential therapeutic target for improving drug sensitivity in
Xinhui Lv, Can Tang, Feiyang Song, Yu Wu, Yafang Chen, Sicong Liu, Ziwen Yuan, Guihua Wang, Xudong Wang   +8 more
wiley   +1 more source

ACT Now or Later: The Economics of Malaria Resistance [PDF]

In the past, malaria control efforts in sub-Saharan Africa have relied on a combination of vector control and effective treatment using chloroquine. With increasing resistance to chloroquine, attention has now turned to alternative treatment strategies ...
Laxminarayan, Ramanan
core  

The VCPIP1‐UBE3A Deubiquitination‐Ubiquitination Cascade Contributes to Castration‐Resistant Prostate Cancer Progression

Advanced Science, EarlyView.
VCIPIP1 emerges as a molecular link between protein stability and prostate cancer progression. By deubiquitinating and stabilizing UBE3A, VCIPIP1 promotes p53 degradation and progression to castration‐resistant prostate cancer. Elevated VCIPIP1 expression is associated with shorter castration‐resistant prostate cancer–free survival, highlighting the ...
Fei Lin, Wen‐Cai Zheng, Yi‐Qiu Wang, Bin Lin, Yun‐Zhi Lin, Dong‐Ning Chen, Xiao‐Dong Li, Xue‐Yi Xue, Yong Wei, Ning Xu   +9 more
wiley   +1 more source

Transcripts of the multidrug resistance genes in chloroquine-sensitive and chloroquine-resistantPlasmodium falciparum

Parasitology, 1993
SUMMARYHomologues of the mammalian multidrug resistance gene have been identified in isolates and clones ofPlasmodium falciparumand designatedpfmdr1andpfmdr2.Mutations inpfmdr1have been associated with chloroquine resistance but confirmation could not be obtained in a genetic cross.
R M, Ekong, K J, Robson, D A, Baker, D C, Warhurst   +3 more
openaire   +2 more sources

Carriage of chloroquine-resistant parasites and delay of effective treatment increase the risk of severe malaria in Gambian children.

, 2005
Two hundred thirty-four Gambian children with severe falciparum malaria who were admitted to the pediatric ward of a rural district hospital each were matched for age with a same-sex control subject presenting as an outpatient with uncomplicated ...
Bousema, T., Ord, Rosalynn, van Niekerk, Maarten, Walraven, Gijs, Osman, E., Bousema, J Teun, Meerman, Larissa, Osman, Emilia, Niekerk, M. van, Sutherland, Colin J, Hallett, Rachel, Meerman, L., Pinder, M., Walraven, G.E., Sutherland, C.J., Pinder, Margaret, Ord, R., Hallett, R.   +17 more
core   +1 more source

Immunoglobulin G antibodies to merozoite surface antigens are associated with recovery from chloroquine-resistant Plasmodium falciparum in Gambian children. [PDF]

, 2006
We examined the hypothesis that recovery from uncomplicated malaria in patients carrying drug-resistant Plasmodium falciparum is a measure of acquired functional immunity and may therefore be associated with humoral responses to candidate vaccine ...
Jamila Ismaili, Holder, Anthony A, Ord, Rosalyn, Sutherland, Colin J, Hallett, Rachel, Rachel Hallett, McCall, Matthew BB, Ismaili, Jamila, Paul Milligan, Pinder, M., Colin J. Sutherland, Ismaili, J., Milligan, Paul, Milligan, P., Matthew B. B. McCall, McCall, M.B.B., Sisay-Joof, F., Holder, A.A., Anthony A. Holder, Rosalyn Ord, Margaret Pinder, Sutherland, C.J., Fatoumatta Sisay-Joof, Pinder, Margaret, Ord, R., Hallett, R., Sisay-Joof, Fatoumatta   +26 more
core   +1 more source