Results 81 to 90 of about 2,244,050 (276)

Targeting Tex10 Overcomes Oxaliplatin Resistance by Competitively Disrupting the Non‐Canonical BAF Complex in Colorectal Cancer

Advanced Science, EarlyView.
This study reveals that Tex10 drives oxaliplatin resistance in colorectal cancer by competitively binding BRD9 to disrupt the ncBAF complex, thereby suppressing AMBRA1 transcription and ULK1‐mediated autophagy. Gemcitabine is identified as a direct Tex10 inhibitor that restores autophagy and overcomes resistance.
Ping Xu, Jie Huang, Xiaojin Gao, Lin Deng, Yanheng Deng, Denglu Wang, Chunlei Yu, Yunxiang Zhang, Jingdong Li, Xiaocong Xiang   +9 more
wiley   +1 more source

Clinical implications of chloroquine and hydroxychloroquine ototoxicity for COVID-19 treatment: A mini-review [PDF]

, 2020
At this time of the COVID-19 pandemic, potentially effective treatments are currently under urgent investigation. Benefits of chloroquine and hydroxychloroquine for the treatment of COVID-19 infection have been proposed and clinical trials are underway ...
Kasbekar, Anand V, Prayuenyong, Pattarawadee, Baguley, David M   +2 more
core   +1 more source

Fibrillarin Resists Cellular Senescence Via SIRT1‐Dependent Nicotinamide Metabolism and Its Inhibition Sensitizes Senolytic Therapy in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
FBL directly binds to and stabilizes SIRT1 by blocking its ubiquitin‐proteasome degradation, thereby sustaining nicotinamide metabolism and redox homeostasis to counteract cellular senescence in ESCC. Genetic and pharmacological suppression of FBL sensitizes tumor cells to senolytic therapy.
Xing Jin, Hong Liu, Ling Gao, Lei Liu, Ji‐Bin Liu, Xiaoxia Jin, Ming‐Song Wang, Dan Liu, Li Feng, Wen‐Lian Chen   +9 more
wiley   +1 more source

Chloroquine analogs as antimalarial candidates with potent in vitro and in vivo activity

International Journal for Parasitology: Drugs and Drug Resistance, 2018
In spite of recent efforts to eradicate malaria in the world, this parasitic disease is still considered a major public health problem, with a total of 216 million cases of malaria and 445,000 deaths in 2016.
Anna C.C. Aguiar, Erika Murce, Wilian A. Cortopassi, Andre S. Pimentel, Maria M.F.S. Almeida, Daniele C.S. Barros, Jéssica S. Guedes, Mario R. Meneghetti, Antoniana U. Krettli   +8 more
doaj   +1 more source

Seasonal carriage of pfcrt and pfmdr1 alleles in Gambian Plasmodium falciparum imply reduced fitness of chloroquine-resistant parasites. [PDF]

, 2007
BACKGROUND: Observations in natural Plasmodium falciparum populations after removal of failing drugs suggest that there is a fitness cost of drug resistance.
Ord, Rosalynn, Jawara, Musa, Neal Alexander, Sam Dunyo, Sutherland, Colin J, Hallett, Rachel, Rachel Hallett, Alexander, Neal, Drakeley, Christopher J, Colin J. Sutherland, Dunyo, Sam, Rosalynn Ord, Musa Jawara, Geoffrey Targett, Targett, Geoffrey, Christopher J. Drakeley   +15 more
core   +1 more source

METTL7A Downregulation Drives SLC1A5‐Mediated Glutamine Competition to Promote Tumor Proliferation and Suppress CD8+ T Cell Immunity in Gastric Cancer

Advanced Science, EarlyView.
GC cells enhance glutamine accumulation by upregulating SLC1A5 expression. This upregulation not only boosts GC cell proliferation, but also outcompetes CD8+ T cells for glutamine and suppresses their antitumor immunity. Mechanistically, METTL7A deficiency in GC induces SLC1A5 overexpression via an m6A‐dependent pathway and N‐glycosylation ...
Mingjun Sun, Shuwei Dang, Dazhi Zhou, Lixian Ding, Xun Sun, Wei Suo, Jirui Niu, Qingzhu Yang, Zhicheng Zhang, Yanyan Sun, Jinxing Li, Zhongsheng Chen, Tao Ban, Yingji Wang, Tianzhu Li, Ming Liu, Guodong Li   +16 more
wiley   +1 more source

Induction of Methuosis in Breast Cancer Stem Cells by a Cobalt(III) Complex Evokes Immunotherapeutic Response

Angewandte Chemie, EarlyView.
Cancer stem cells (CSCs) drive metastasis, relapse and resist conventional apoptosis‐inducing chemotherapies. We report a cobalt(III)‐cyclam complex with pyrene and diflunisal moieties that reduces the viability of breast CSCs at low micromolar concentrations.
Jiaxin Fang, Sijie Wen, Xiao Feng, Hao Ren, Kuldip Singh, Haihua Xiao, Lingpu Zhang, Kogularamanan Suntharalingam   +7 more
wiley   +2 more sources

Association of house spraying with suppressed levels of drug resistance in Zimbabwe

Malaria Journal, 2004
Background Public health strategies are needed to curb antimalarial drug resistance. Theoretical argument points to an association between malaria transmission and drug resistance although field evidence remains limited.
Chandiwana Steven K, Chimbadzwa Tawanda, Mudyiradima Robert, Mutambu Susan L, Mharakurwa Sungano, Day Karen P   +5 more
doaj   +1 more source

Two novel assays for the detection of haemin-binding properties of antimalarials evaluated with compounds isolated from medicinal plants. [PDF]

, 2002
Forty-two compounds isolated from nine plants used within South America for the treatment of malaria were tested for haemin binding using two novel, rapid screening methods.
Steele, JCP, Phelps, RJ, Meyer, DJ, Warhurst, DC, Simmonds, MSJ, J. C. P. Steele   +5 more
core   +1 more source

Targeting β2‐Adrenergic Receptor Stability With Lycorine Reveals a Host‐Directed Pathway for Antiviral Defense Against Poxviruses

Advanced Science, EarlyView.
Chronic stress drives autophagy‐mediated β2‐AR degradation, impairing antiviral immunity and promoting poxvirus lethality. Lycorine directly stabilizes β2‐AR to restore host defense, suppress excessive inflammation and improve survival. ABSTRACT Psychological stress is a pervasive yet poorly understood modulator of infectious disease outcomes. Here, we
Xin Zhang, Shuqin Xu, Zixuan Zhang, Chenwen Wan, Xiaoqin Wang, Peihua Wang, Huini Yang, Tianxiao Huang, Yijia Yuan, Faiza Atique, Rui Yang, Yingli He, Zhijun Liu   +12 more
wiley   +1 more source