Results 21 to 30 of about 2,244,050 (276)

Polymorphisms in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance 1 genes: parasite risk factors that affect treatment outcomes for P. falciparum malaria after artemether-lumefantrine and artesunate-amodiaquine. [PDF]

, 2014
Adequate clinical and parasitologic cure by artemisinin combination therapies relies on the artemisinin component and the partner drug. Polymorphisms in the Plasmodium falciparum chloroquine resistance transporter (pfcrt) and P.
Kamugisha, Erasmus, Piola, Patrice, Faucher, Jean-François, El-Sayed, Badria, Houzé, Sandrine, Somé, A Fabrice, Sutherland, Colin, Checchi, Francesco, Plowe, Christopher, V, Sutherland, Colin J, Otienoburu, Sabina Dahlström, Berens-Riha, Nicole, Grivoyannis, Anastasia, Davis, Timothy ME, Björkman, Anders, Asaq Molecular Marker Study Group, Rosenthal, Philip, Eyase, Frederick, Malmberg, Maja, Kariuki, Simon, Mårtensson, Andreas,, Hamour, Sally, Ogutu, Bernhards, Davis, Timothy, Wong, Rina, Sibley, Carol Hopkins, Gadalla, Nahla B, Ngasala, Billy, Ménard, Didier, Oguike, Mary, Venkatesan, Meera, Arze, Cesar, Djimdé, Abdoulaye A, Baliraine, Frederick N, Fröberg, Gabrielle, Ursing, Johan, LeBras, Jacques, Desai, Meghna, Mårtensson, Andreas, Ouédraogo, Jean-Bosco, El-Sayed, Badria B, Mwai, Leah, Thwing, Julie, Kironde, Fred, Djimde, Abdoulaye, Price, Ric, Dorsey, Grant, Johnson, Jacob, Guérin, Philippe, Somé, A. Fabrice, Oguike, Alexis Nzila Mary, LeBras, Poul-Erik Kofoed Jacques, Moriera, Clarissa, Kiechel, Jean-René, Kofoed, Poul-Erik, Dahal, Prabin, Nsanzabana, Christian, Nzila, Alexis, Wong, Rina PM, Rosenthal, Philip J, Ademowo, George, Falade, Catherine, Nsobya, Samuel L, Schramm, Birgit, Zongo, Issaka, Gadalla, Nahla, Wong, Rina P M, Plowe, Christopher V, Eshetu, Teferi, Davis, Timothy M E, Dhorda, Meghna Desai Mehul, Plowe, Christopher,, Rombo, Lars,, Dhorda, Mehul, Stepniewska, Kasia, Adam, Ishag, Price, Ric N, Borrmann, Steffen, Nosten, Francois, Rombo, Lars, Baliraine, Frederick, Zeynudin, Ahmed, Nsobya, Samuel   +82 more
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Plasmodium falciparum K76T pfcrt Gene Mutations and Parasite Population Structure, Haiti, 2006–2009

Emerging Infectious Diseases, 2016
Hispaniola is the only Caribbean island to which Plasmodium falciparum malaria remains endemic. Resistance to the antimalarial drug chloroquine has rarely been reported in Haiti, which is located on Hispaniola, but the K76T pfcrt (P.
Macarthur Charles, Sanchita Das, Rachel Daniels, Laura Kirkman, Glavdia G. Delva, Rodney Destine, Ananias A. Escalante, Leopoldo Villegas, Noah M. Daniels, Kristi Shigyo, Sarah K. Volkman, Jean W. Pape, Linnie M. Golightly   +12 more
doaj   +1 more source

Azithromycin-chloroquine and the intermittent preventive treatment of malaria in pregnancy. [PDF]

, 2008
In the high malaria-transmission settings of sub-Saharan Africa, malaria in pregnancy is an important cause of maternal, perinatal and neonatal morbidity.
Chandramohan, Daniel, Chico, R Matthew, Pittrof, Rudiger, Pittrof Rudiger, Daniel Chandramohan, Chico R Matthew, Greenwood Brian, Rudiger Pittrof, Greenwood, Brian, Brian Greenwood, Chandramohan Daniel, R Matthew Chico   +11 more
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Mefloquine resistant malaria in cameroon and correlation with resistance quinine

Memorias do Instituto Oswaldo Cruz, 1992
Based on the results of in vitro sensitivity of Plasmodium falciparum to chloroquine, quinine and mefloquine, and evaluation of drug consumption conducted in 1987-1988 in four areas in the noth and south-west of Cameron, two opposite situations were ...
P. Brasseur, J. Kouamouo, R. S. Moyou, P. Druilhe   +3 more
doaj   +1 more source

Characterization of the commercially-available fluorescent chloroquine-BODIPY conjugate, LynxTag-CQGREEN, as a marker for chloroquine resistance and uptake in a 96-well plate assay. [PDF]

PLoS ONE, 2014
Chloroquine was a cheap, extremely effective drug against Plasmodium falciparum until resistance arose. One approach to reversing resistance is the inhibition of chloroquine efflux from its site of action, the parasite digestive vacuole.
Cheryl C Y Loh, Rossarin Suwanarusk, Yan Quan Lee, Kitti W K Chan, Kit-Ying Choy, Laurent Rénia, Bruce Russell, Martin J Lear, François H Nosten, Kevin S W Tan, Larry M C Chow   +10 more
doaj   +1 more source

Dihydroartemisinin-piperaquine versus chloroquine to treat vivax malaria in Afghanistan: an open randomized, non-inferiority, trial. [PDF]

, 2010
BACKGROUND: Afghanistan's national guidelines recommend chloroquine for the treatment of Plasmodium vivax infection, the parasite responsible for the majority of its malaria burden. Chloroquine resistance in P. vivax is emerging in Asia.
Faizullah Kaker, Dondorp Arjen M, Sasithon Pukrittayakamee, Dondorp, AM, Sue Lee, Woodrow, CJ, Singhasivanon Pratap, Pukrittayakamee Sasithon, Pukrittayakamee, S, Pratap Singhasivanon, Arjen M Dondorp, Nicholas PJ Day, Day, NP, Day Nicholas PJ, Charles J Woodrow, White Nicholas J, Lee, SJ, Singhasivanon, P, Awab, GR, Kaker Faizullah, Imwong Mallika, Dondorp, Adrianus, Nicholas J White, Mallika Imwong, Imwong, Mallika, Imwong, M, Day, Nicholas, White, NJ, White, Nicholas, Awab Ghulam, Ghulam Awab, Woodrow Charles J, Lee Sue, Kaker, F   +33 more
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Leveraging the effects of chloroquine on resistant malaria parasites for combination therapies

BMC Bioinformatics, 2019
Background Malaria is a major global health problem, with the Plasmodium falciparum protozoan parasite causing the most severe form of the disease. Prevalence of drug-resistant P. falciparum highlights the need to understand the biology of resistance and
Ana M. Untaroiu, Maureen A. Carey, Jennifer L. Guler, Jason A. Papin   +3 more
doaj   +1 more source

The multifocal pattern electroretinogram in chloroquine retinopathy [PDF]

, 2004
Purpose: Optimal screening for ocular toxicity caused by chloroquine and hydroxychloroquine is still controversial. With the multifocal pattern electroretinogram (mfPERG), a new electrophysiological technique has recently become available to detect early
Stiefelmeyer, S., Berninger, T., Neubauer, A. S., Arden, G. B., Rudolph, G.   +4 more
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Antimalarial therapy selection for quinolone resistance among Escherichia coli in the absence of quinolone exposure, in tropical South America. [PDF]

PLoS ONE, 2008
BackgroundBacterial resistance to antibiotics is thought to develop only in the presence of antibiotic pressure. Here we show evidence to suggest that fluoroquinolone resistance in Escherichia coli has developed in the absence of fluoroquinolone use ...
Ross J Davidson, Ian Davis, Barbara M Willey, Keyro Rizg, Shelly Bolotin, Vanessa Porter, Jane Polsky, Nick Daneman, Allison McGeer, Paul Yang, Dennis Scolnik, Roy Rowsell, Olga Imas, Michael S Silverman   +13 more
doaj   +1 more source

Concurrence of Plasmodium falciparum dhfr and crt mutations in northern Ghana. [PDF]

, 2005
BACKGROUND: Both chloroquine (CQ) and sulfadoxine-pyrimethamine (SP) are failing drugs in much of sub-Saharan Africa. Previous findings suggest an association between resistance to CQ and to SP in vivo, in vitro, and on the molecular level.
Bousema J Teun, Sauerwein, Robert W, Teunis A Eggelte, Bousema, J. Teun, Bienzle Ulrich, Bousema, J Teun, Ehrhardt, Stephan, Eggelte Teunis A, Mockenhaupt Frank P, Otchwemah, Rowland N., Ehrhardt Stephan, Otchwemah, Rowland N, Bienzle, Ulrich, Mockenhaupt, Frank P., Mockenhaupt, Frank P, J Teun Bousema, Rowland N Otchwemah, Eggelte, Teunis A, Eggelte, Teunis A., Ulrich Bienzle, Stephan Ehrhardt, Otchwemah Rowland N, Sauerwein Robert W, Frank P Mockenhaupt, Robert W Sauerwein, Sauerwein, Robert W.   +25 more
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