Results 21 to 30 of about 2,436,233 (271)

The Drug Resistance of Plasmodium falciparum and P. vivax in Iran: A Review Article

Iranian Journal of Parasitology, 2021
Background: One of the main obstacles to malaria control in the world has been the emergence of resistance in Plasmodium falciparum to chloroquine and other anti-malarial drugs. This study aimed to review studies in Iran on resistance in P.
Aliehsan Heidari, Hossein Keshavarz
doaj   +1 more source

In Vitro Antiplasmodium and Chloroquine Resistance Reversal Effects of Andrographolide. [PDF]

Evid Based Complement Alternat Med, 2019
The emergence of drug-resistant strains of Plasmodium falciparum is the worst catastrophe that has ever confronted the dedicated efforts to eradicate malaria. This urged for searching other alternatives or sensitizers that reverse chloroquine resistance.
Ibraheem ZO, Majid RA, Sidek HM, Noor SM, Yam MF, Abd Rachman Isnadi MF, Basir R.   +6 more
europepmc   +2 more sources

Clinical and parasitological response to oral chloroquine and primaquine in uncomplicated human Plasmodium knowlesi infections. [PDF]

, 2010
BACKGROUND: Plasmodium knowlesi is a cause of symptomatic and potentially fatal infections in humans. There are no studies assessing the detailed parasitological response to treatment of knowlesi malaria infections in man and whether antimalarial ...
Cox-Singh, J, Siti Khatijah, Binti Zakaria, Daneshvar, C., Zakaria Siti K, Paul CS Divis, Daneshvar, C, Singh Balbir, Balbir, Singh, Divis Paul CS, Rafa'ee, Mohammad Z., Singh, Balbir, Janet Cox-Singh, Daneshvar, Cyrus, Mohammad Zakri, Rafa’ee, Rafa'ee Mohammad Z, Divis, Paul C. S., Singh, B, Balbir Singh, Daneshvar Cyrus, Cox-Singh Janet, Timothy ME Davis, Siti K Zakaria, Zakaria, SK, Davis, T.M.E, Cyrus CyrusDaneshvar, Paul C, Divis, Cox Singh, Janet, Davis, TM, Davis, Timothy M. E., Rafa'ee, MZ, Davis Timothy ME, Mohammad Z Rafa'ee, Cox-Singh, J., Cyrus Daneshvar, Zakaria, Siti K., Divis, PC, Cox Singh, Janet; id_orcid   +36 more
core   +1 more source

Plasmodium falciparum K76T pfcrt Gene Mutations and Parasite Population Structure, Haiti, 2006–2009

Emerging Infectious Diseases, 2016
Hispaniola is the only Caribbean island to which Plasmodium falciparum malaria remains endemic. Resistance to the antimalarial drug chloroquine has rarely been reported in Haiti, which is located on Hispaniola, but the K76T pfcrt (P.
Macarthur Charles, Sanchita Das, Rachel Daniels, Laura Kirkman, Glavdia G. Delva, Rodney Destine, Ananias A. Escalante, Leopoldo Villegas, Noah M. Daniels, Kristi Shigyo, Sarah K. Volkman, Jean W. Pape, Linnie M. Golightly   +12 more
doaj   +1 more source

Assessment of the molecular marker of Plasmodium falciparum chloroquine resistance (Pfcrt) in Senegal after several years of chloroquine withdrawal. [PDF]

, 2012
As a result of widespread antimalarial drug resistance, all African countries with endemic malaria have, in recent years, changed their malaria treatment policy.
Dieng, Yemou, Annie Abiola, Aminata Lo, Ndiaye, Daouda, Daouda Ndiaye, Yemou Dieng, Roger Tine, Faye, Babacar, Babacar Faye, Ndiaye, Magatte, Jean Louis Ndiaye, Lo, Aminata, Hallett, Rachel, Ndiaye, Jean Louis, Gaye, Oumar, Magatte Ndiaye, Rachel Hallett, Oumar Gaye, Michael Alifrangis, Tine, Roger, Alifrangis, Michael, Abiola, Annie   +21 more
core   +1 more source

Leveraging the effects of chloroquine on resistant malaria parasites for combination therapies

BMC Bioinformatics, 2019
Background Malaria is a major global health problem, with the Plasmodium falciparum protozoan parasite causing the most severe form of the disease. Prevalence of drug-resistant P. falciparum highlights the need to understand the biology of resistance and
Ana M. Untaroiu, Maureen A. Carey, Jennifer L. Guler, Jason A. Papin   +3 more
doaj   +1 more source

Characterization of the commercially-available fluorescent chloroquine-BODIPY conjugate, LynxTag-CQGREEN, as a marker for chloroquine resistance and uptake in a 96-well plate assay. [PDF]

PLoS ONE, 2014
Chloroquine was a cheap, extremely effective drug against Plasmodium falciparum until resistance arose. One approach to reversing resistance is the inhibition of chloroquine efflux from its site of action, the parasite digestive vacuole.
Cheryl C Y Loh, Rossarin Suwanarusk, Yan Quan Lee, Kitti W K Chan, Kit-Ying Choy, Laurent Rénia, Bruce Russell, Martin J Lear, François H Nosten, Kevin S W Tan, Larry M C Chow   +10 more
doaj   +1 more source

Dihydroartemisinin-piperaquine versus chloroquine to treat vivax malaria in Afghanistan: an open randomized, non-inferiority, trial. [PDF]

, 2010
BACKGROUND: Afghanistan's national guidelines recommend chloroquine for the treatment of Plasmodium vivax infection, the parasite responsible for the majority of its malaria burden. Chloroquine resistance in P. vivax is emerging in Asia.
Faizullah Kaker, Dondorp Arjen M, Sasithon Pukrittayakamee, Dondorp, AM, Sue Lee, Woodrow, CJ, Singhasivanon Pratap, Pukrittayakamee Sasithon, Pukrittayakamee, S, Pratap Singhasivanon, Arjen M Dondorp, Nicholas PJ Day, Day, NP, Day Nicholas PJ, Charles J Woodrow, White Nicholas J, Lee, SJ, Singhasivanon, P, Awab, GR, Kaker Faizullah, Imwong Mallika, Nicholas J White, Mallika Imwong, Imwong, M, White, NJ, Awab Ghulam, Ghulam Awab, Woodrow Charles J, Lee Sue, Kaker, F   +29 more
core   +1 more source

Mefloquine resistant malaria in cameroon and correlation with resistance quinine

Memorias do Instituto Oswaldo Cruz, 1992
Based on the results of in vitro sensitivity of Plasmodium falciparum to chloroquine, quinine and mefloquine, and evaluation of drug consumption conducted in 1987-1988 in four areas in the noth and south-west of Cameron, two opposite situations were ...
P. Brasseur, J. Kouamouo, R. S. Moyou, P. Druilhe   +3 more
doaj   +1 more source

Malaria: Dissecting chloroquine resistance [PDF]

Current Biology, 1998
The malaria parasite's development of resistance to the drug chloroquine is a major threat to world health. A protein likely to be involved in chloroquine resistance has recently been identified; this discovery is important, but raises as many questions as it answers.
openaire   +2 more sources