Results 11 to 20 of about 2,436,233 (271)

Polymorphisms in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance 1 genes: parasite risk factors that affect treatment outcomes for P. falciparum malaria after artemether-lumefantrine and artesunate-amodiaquine. [PDF]

, 2014
Adequate clinical and parasitologic cure by artemisinin combination therapies relies on the artemisinin component and the partner drug. Polymorphisms in the Plasmodium falciparum chloroquine resistance transporter (pfcrt) and P.
Sibley, CH, Malmberg, M, Nsobya, SL, Lebras, J, Nsanzabana, C, Faucher, JF, Thwing, J, Somé, AF, Ogutu, B, Houzé, S, Gadalla, NB, Björkman, A, Desai, M, Schramm, B, Venkatesan, M, Oguike, M, Ménard, D, Hamour, S, Plowe, CV, Dhorda, M, Djimdé, AA, Borrmann, S, Dorsey, G, Wong, RP, Fröberg, G, Stepniewska, K, Guérin, P, Kiechel, JR, Baliraine, FN, Johnson, J, Rombo, L, Kariuki, S, Ouédraogo, JB, Ademowo, G, Kofoed, PE, Grivoyannis, A, Falade, C, Sutherland, CJ, Nzila, A, Piola, P, Zongo, I, Eshetu, T, Dahal, P, Kamugisha, E, Ngasala, B, El-Sayed, BB, Rosenthal, PJ, Nosten, F, Eyase, F, Ursing, J, Otienoburu, SD, Davis, TM, Adam, I, Kironde, F, Zeynudin, A, Checchi, F, Moriera, C, Arze, C, Berens-Riha, N, Mwai, L, Price, RN, Faucher, Jean-François, Houzé, Sandrine, Somé, A Fabrice, Sutherland, Colin, Checchi, Francesco, Berens-Riha, Nicole, Davis, Timothy ME, Björkman, Anders, Asaq Molecular Marker Study Group, Rosenthal, Philip, Eyase, Frederick, Kariuki, Simon, Mårtensson, Andreas,, Davis, Timothy, Gadalla, Nahla B, Ménard, Didier, Arze, Cesar, Djimdé, Abdoulaye A, Fröberg, Gabrielle, Ursing, Johan, Desai, Meghna, Mårtensson, Andreas, Ouédraogo, Jean-Bosco, Mwai, Leah, Kironde, Fred, Djimde, Abdoulaye, Dorsey, Grant, Johnson, Jacob, Guérin, Philippe, Somé, A. Fabrice, Oguike, Alexis Nzila Mary, LeBras, Poul-Erik Kofoed Jacques, Kofoed, Poul-Erik, Dahal, Prabin, Nzila, Alexis, Wong, Rina PM, Nsobya, Samuel L, Zongo, Issaka, Gadalla, Nahla, Dhorda, Meghna Desai Mehul, Plowe, Christopher,, Rombo, Lars,, Stepniewska, Kasia, Adam, Ishag, Price, Ric N, Rombo, Lars, Kamugisha, Erasmus, Piola, Patrice, El-Sayed, Badria, Plowe, Christopher, V, Sutherland, Colin J, Otienoburu, Sabina Dahlström, Grivoyannis, Anastasia, Malmberg, Maja, Hamour, Sally, Ogutu, Bernhards, Wong, Rina, Sibley, Carol Hopkins, Ngasala, Billy, Oguike, Mary, Venkatesan, Meera, Baliraine, Frederick N, LeBras, Jacques, El-Sayed, Badria B, Thwing, Julie, Price, Ric, Moriera, Clarissa, Kiechel, Jean-René, Nsanzabana, Christian, Rosenthal, Philip J, Ademowo, George, Falade, Catherine, Schramm, Birgit, Wong, Rina P M, Plowe, Christopher V, Eshetu, Teferi, Davis, Timothy M E, Dhorda, Mehul, Borrmann, Steffen, Nosten, Francois, Baliraine, Frederick, Zeynudin, Ahmed, Nsobya, Samuel, Martensson, A   +144 more
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Azithromycin plus chloroquine: combination therapy for protection against malaria and sexually transmitted infections in pregnancy. [PDF]

, 2011
INTRODUCTION: The first-line therapy for the intermittent preventive treatment of malaria in pregnancy (IPTp) is sulphadoxine-pyrimethamine (SP).
Chandramohan, Daniel, Chico, R Matthew, Daniel Chandramohan, R Matthew Chico   +3 more
core   +1 more source

Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, enlarge the parasite's food vacuole and alter drug sensitivities [PDF]

, 2015
Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, are the major determinant of chloroquine resistance in this lethal human malaria parasite. Here, we describe P.
Staines, Henry M., Mu, Jianbing, Lee, Andrew H., Pulcini, Serena, Daley, Daniel A., Fidock, David A., Cooper, Roland A., Shafik, Sarah H., Altenhofen, Lindsey M., Krishna, Sanjeev, Martin, Rowena E., Painter, Heather J., Hoke, Matthew J., Llinás, Manuel, Moore, Catherine M., Bouyer, Guillaume, Ferguson, David J.P.   +16 more
core   +3 more sources

Patterns of chloroquine use and resistance in sub-Saharan Africa: a systematic review of household survey and molecular data

Malaria Journal, 2011
Background As a result of widespread chloroquine and sulphadoxine-pyrimethamine (SP) resistance, 90% of sub-Saharan African countries had adopted policies of artemisinin-based combination therapy (ACT) for treatment of uncomplicated malaria by 2007.
Venkatesan Meera, Frosch Anne EP, Laufer Miriam K   +2 more
doaj   +1 more source

Chloroquine resistant Plasmodium vivax: in vitro characterisation and association with molecular polymorphisms. [PDF]

PLoS ONE, 2007
Treatment failure of chloroquine for P. vivax infections has reached high levels in the eastern provinces of Indonesia, however, in vitro characterization of chloroquine resistance and its associated molecular profile have yet to be determined.Using a ...
Rossarin Suwanarusk, Bruce Russell, Marina Chavchich, Ferryanto Chalfein, Enny Kenangalem, Varakorn Kosaisavee, Budi Prasetyorini, Kim A Piera, Marion Barends, Alan Brockman, Usa Lek-Uthai, Nicholas M Anstey, Emiliana Tjitra, François Nosten, Qin Cheng, Ric N Price   +15 more
doaj   +1 more source

Persistence of chloroquine-resistant haplotypes of Plasmodium falciparum in children with uncomplicated Malaria in Lagos, Nigeria, four years after change of chloroquine as first-line antimalarial medicine. [PDF]

, 2015
BACKGROUND: In Nigeria, despite the change in National malaria drug policy to artemisinin combination therapy (ACT) in 2005 due to widespread chloroquine resistance, chloroquine (CQ) is still widely used in the treatment of malaria because it is cheap ...
Sutherland, Colin J, Oladipo, Oladosu O, Wellington, Oyibo A   +2 more
core   +1 more source

Diversity of Plasmodium falciparum chloroquine resistance transporter (pfcrt) exon 2 haplotypes in the Pacific from 1959 to 1979. [PDF]

PLoS ONE, 2012
Nearly one million deaths are attributed to malaria every year. Recent reports of multi-drug treatment failure of falciparum malaria underscore the need to understand the molecular basis of drug resistance. Multiple mutations in the Plasmodium falciparum
Chim W Chan, Rita Spathis, Dana M Reiff, Stacy E McGrath, Ralph M Garruto, J Koji Lum   +5 more
doaj   +1 more source

Azithromycin-chloroquine and the intermittent preventive treatment of malaria in pregnancy. [PDF]

, 2008
In the high malaria-transmission settings of sub-Saharan Africa, malaria in pregnancy is an important cause of maternal, perinatal and neonatal morbidity.
Chandramohan, Daniel, Chico, R Matthew, Pittrof, Rudiger, Pittrof Rudiger, Daniel Chandramohan, Chico R Matthew, Greenwood Brian, Rudiger Pittrof, Greenwood, Brian, Brian Greenwood, Chandramohan Daniel, R Matthew Chico   +11 more
core   +1 more source

Quantitative genome re-sequencing defines multiple mutations conferring chloroquine resistance in rodent malaria

BMC Genomics, 2012
Background Drug resistance in the malaria parasite Plasmodium falciparum severely compromises the treatment and control of malaria. A knowledge of the critical mutations conferring resistance to particular drugs is important in understanding modes of ...
Kinga Modrzynska Katarzyna, Creasey Alison, Loewe Laurence, Cezard Timothee, Trindade Borges Sofia, Martinelli Axel, Rodrigues Louise, Cravo Pedro, Blaxter Mark, Carter Richard, Hunt Paul   +10 more
doaj   +1 more source

CHLOROQUINE RESISTANCE IN MALARIA: A DEFICIENCY OF CHLOROQUINE BINDING [PDF]

Proceedings of the National Academy of Sciences, 1969
Chloroquine- 14 C was used to study the processes which concentrate chloroquine in mouse red blood cells infected with chloroquine-sensitive or with chloroquine-resistant Plasmodium berghei . The initial rates of uptake and exchange of chloroquine-
openaire   +2 more sources