Results 11 to 20 of about 2,244,050 (276)

Malaria: Dissecting chloroquine resistance [PDF]

Current Biology, 1998
The malaria parasite's development of resistance to the drug chloroquine is a major threat to world health. A protein likely to be involved in chloroquine resistance has recently been identified; this discovery is important, but raises as many questions as it answers.
Ridley, Robert G.
openaire   +4 more sources

Persistence of chloroquine-resistant haplotypes of Plasmodium falciparum in children with uncomplicated Malaria in Lagos, Nigeria, four years after change of chloroquine as first-line antimalarial medicine. [PDF]

, 2015
BACKGROUND: In Nigeria, despite the change in National malaria drug policy to artemisinin combination therapy (ACT) in 2005 due to widespread chloroquine resistance, chloroquine (CQ) is still widely used in the treatment of malaria because it is cheap ...
Sutherland, Colin J, Oladipo, Oladosu O, Wellington, Oyibo A   +2 more
core   +1 more source

Azithromycin plus chloroquine: combination therapy for protection against malaria and sexually transmitted infections in pregnancy. [PDF]

, 2011
INTRODUCTION: The first-line therapy for the intermittent preventive treatment of malaria in pregnancy (IPTp) is sulphadoxine-pyrimethamine (SP).
Chandramohan, Daniel, Chico, R Matthew, Daniel Chandramohan, R Matthew Chico   +3 more
core   +1 more source

Chloroquine resistant Plasmodium vivax: in vitro characterisation and association with molecular polymorphisms. [PDF]

PLoS ONE, 2007
Treatment failure of chloroquine for P. vivax infections has reached high levels in the eastern provinces of Indonesia, however, in vitro characterization of chloroquine resistance and its associated molecular profile have yet to be determined.Using a ...
Rossarin Suwanarusk, Bruce Russell, Marina Chavchich, Ferryanto Chalfein, Enny Kenangalem, Varakorn Kosaisavee, Budi Prasetyorini, Kim A Piera, Marion Barends, Alan Brockman, Usa Lek-Uthai, Nicholas M Anstey, Emiliana Tjitra, François Nosten, Qin Cheng, Ric N Price   +15 more
doaj   +1 more source

Diversity of Plasmodium falciparum chloroquine resistance transporter (pfcrt) exon 2 haplotypes in the Pacific from 1959 to 1979. [PDF]

PLoS ONE, 2012
Nearly one million deaths are attributed to malaria every year. Recent reports of multi-drug treatment failure of falciparum malaria underscore the need to understand the molecular basis of drug resistance. Multiple mutations in the Plasmodium falciparum
Chim W Chan, Rita Spathis, Dana M Reiff, Stacy E McGrath, Ralph M Garruto, J Koji Lum   +5 more
doaj   +1 more source

Assessment of the molecular marker of Plasmodium falciparum chloroquine resistance (Pfcrt) in Senegal after several years of chloroquine withdrawal. [PDF]

, 2012
As a result of widespread antimalarial drug resistance, all African countries with endemic malaria have, in recent years, changed their malaria treatment policy.
Dieng, Yemou, Annie Abiola, Aminata Lo, Ndiaye, Daouda, Daouda Ndiaye, Yemou Dieng, Roger Tine, Faye, Babacar, Babacar Faye, Ndiaye, Magatte, Jean Louis Ndiaye, Lo, Aminata, Hallett, Rachel, Ndiaye, Jean Louis, Gaye, Oumar, Magatte Ndiaye, Rachel Hallett, Oumar Gaye, Michael Alifrangis, Tine, Roger, Alifrangis, Michael, Abiola, Annie   +21 more
core   +1 more source

Quantitative genome re-sequencing defines multiple mutations conferring chloroquine resistance in rodent malaria

BMC Genomics, 2012
Background Drug resistance in the malaria parasite Plasmodium falciparum severely compromises the treatment and control of malaria. A knowledge of the critical mutations conferring resistance to particular drugs is important in understanding modes of ...
Kinga Modrzynska Katarzyna, Creasey Alison, Loewe Laurence, Cezard Timothee, Trindade Borges Sofia, Martinelli Axel, Rodrigues Louise, Cravo Pedro, Blaxter Mark, Carter Richard, Hunt Paul   +10 more
doaj   +1 more source

CHLOROQUINE RESISTANCE IN MALARIA: A DEFICIENCY OF CHLOROQUINE BINDING [PDF]

Proceedings of the National Academy of Sciences, 1969
Chloroquine- 14 C was used to study the processes which concentrate chloroquine in mouse red blood cells infected with chloroquine-sensitive or with chloroquine-resistant Plasmodium berghei . The initial rates of uptake and exchange of chloroquine-
openaire   +2 more sources

Clinical and parasitological response to oral chloroquine and primaquine in uncomplicated human Plasmodium knowlesi infections. [PDF]

, 2010
BACKGROUND: Plasmodium knowlesi is a cause of symptomatic and potentially fatal infections in humans. There are no studies assessing the detailed parasitological response to treatment of knowlesi malaria infections in man and whether antimalarial ...
Cox-Singh, J, Siti Khatijah, Binti Zakaria, Daneshvar, C., Zakaria Siti K, Paul CS Divis, Daneshvar, C, Singh Balbir, Balbir, Singh, Divis Paul CS, Rafa'ee, Mohammad Z., Singh, Balbir, Janet Cox-Singh, Daneshvar, Cyrus, Mohammad Zakri, Rafa’ee, Rafa'ee Mohammad Z, Divis, Paul C. S., Singh, B, Balbir Singh, Daneshvar Cyrus, Cox-Singh Janet, Timothy ME Davis, Siti K Zakaria, Zakaria, SK, Davis, T.M.E, Cyrus CyrusDaneshvar, Paul C, Divis, Cox Singh, Janet, Davis, TM, Davis, Timothy M. E., Rafa'ee, MZ, Davis Timothy ME, Mohammad Z Rafa'ee, Cox-Singh, J., Cyrus Daneshvar, Zakaria, Siti K., Divis, PC   +35 more
core   +1 more source

The Drug Resistance of Plasmodium falciparum and P. vivax in Iran: A Review Article

Iranian Journal of Parasitology, 2021
Background: One of the main obstacles to malaria control in the world has been the emergence of resistance in Plasmodium falciparum to chloroquine and other anti-malarial drugs. This study aimed to review studies in Iran on resistance in P.
Aliehsan Heidari, Hossein Keshavarz
doaj   +1 more source